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Proteins/UNIPROT:O14756
NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids..
Function from UniProtKB (O14756), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
48 statements
48 statements · 7 reference databases · Subject: HSD17B6 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
21 reactions
androst-4-ene-3,17-dione+proton+NADPH(4-)NADP(3-)+testosterone
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B3 or HSD17B7 or AKR1C3 or HSD17B11 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64cytosol
Human-GEM MAR01973CC BY 4.0Reference data
8 names
Resolves to: HSD17B6
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64endoplasmic reticulum
Human-GEM MAR01974CC BY 4.0Reference data
estrone+proton+NADPH(4-)17beta-estradiol+NADP(3-)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageReversibleBalancedEC 1.1.1.62cytosol
Human-GEM MAR02036CC BY 4.0Reference data
estrone+proton+NADPH(4-)17beta-estradiol+NADP(3-)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageReversibleBalancedEC 1.1.1.62endoplasmic reticulum
Human-GEM MAR02041CC BY 4.0Reference data
NAD(+)+all-trans-retinolproton+NADH(2-)+all-trans-retinal
Catalysed by HSD17B6 or RDH5 or SDR16C5 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.105cytosol
Human-GEM MAR06631CC BY 4.0Reference data
NAD(+)+all-trans-retinolproton+NADH(2-)+all-trans-retinal
Catalysed by HSD17B6 or RDH5 or SDR16C5 or ADH6 or ADH1A or ADH7 or ADH1B or ADH5 or ADH4 or ADH1C
Reaction pageLeft to rightBalancedEC 1.1.1.1, 1.1.1.105endoplasmic reticulum
Human-GEM MAR06633CC BY 4.0Reference data
11-cis-retinal+proton+NADH(2-)11-cis-retinol+NAD(+)
Catalysed by HSD17B6 or RDH5 or RDH16 or RLBP1 or DHRS4 or DHRS4L2 or RBP3
Reaction pageReversibleBalancedEC 1.1.1.105cytosol
Human-GEM MAR06638CC BY 4.0Reference data
9-cis-retinal+proton+NADH(2-)9-cis-retinol+NAD(+)
Catalysed by HSD17B6 or RDH5 or RDH16 or RLBP1 or DHRS4 or SDR16C5 or DHRS4L2 or ADH4 or RBP3
Reaction pageReversibleBalancedEC 1.1.1.105cytosol
Human-GEM MAR06644CC BY 4.0Reference data
androst-4-ene-3,17-dione+proton+NADH(2-)NAD(+)+testosterone
Catalysed by HSD17B6 or HSD17B2 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.239endoplasmic reticulum
Human-GEM MAR07955CC BY 4.0Reference data
estrone+proton+NADH(2-)17beta-estradiol+NAD(+)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64endoplasmic reticulum
Human-GEM MAR07968CC BY 4.0Reference data
11-cis-retinal+proton+NADPH(4-)11-cis-retinol+NADP(3-)
Catalysed by HSD17B6 or RDH5 or RDH16 or RLBP1 or DHRS4 or DHRS4L2 or RBP3
Reaction pageReversibleBalancedEC 1.1.1.105cytosol
Human-GEM MAR08709CC BY 4.0Reference data
testosterone+NAD(1-)androst-4-ene-3,17-dione+NADH(2-)+hydron
Catalysed by HSD17B6 or AKR1C4 or HSD17B2 or AKR1C3 or HSD17B8 or HSD17B10
Reaction pageLeft to rightBalanced
Rhea RHEA:14929CC BY 4.0Reference data