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Proteins/UNIPROT:O75746
Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange of L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation. Lacks transport activity towards L-glutamine or gamma-aminobutyric acid (GABA)..
Function from UniProtKB (O75746), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
187 statements
187 statements · 7 reference databases · Subject: SLC25A12 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
6 reactions
L-aspartate+L-glutamate(1-)+protonL-aspartate+L-glutamate(1-)+proton
Transported by SLC25A13 or SLC25A12
Reaction pageLeft to rightBalancedmitochondrial matrix, cytosol, mitochondrial intermembrane space
Human-GEM MAR03825CC BY 4.0Reference data
3-sulfino-L-alanine+L-aspartate3-sulfino-L-alanine+L-aspartate
6 names
Resolves to: SLC25A12
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR03863CC BY 4.0Reference data
3-sulfino-L-alanine+L-glutamate(1-)+proton3-sulfino-L-alanine+L-glutamate(1-)+proton
Transported by SLC25A13 or SLC25A12
Reaction pageLeft to rightBalancedmitochondrial matrix, cytosol, mitochondrial intermembrane space
Human-GEM MAR03864CC BY 4.0Reference data
L-aspartate+L-glutamate(1-)+hydronL-aspartate+L-glutamate(1-)+hydron
Transported by SLC25A12 or SLC25A13
Reaction pageDirection not assertedBalanced
Rhea RHEA:70783CC BY 4.0Reference data
3-sulfino-L-alanine+L-glutamate(1-)+hydron3-sulfino-L-alanine+L-glutamate(1-)+hydron
Transported by SLC25A12 or SLC25A13
Reaction pageDirection not assertedBalanced
Rhea RHEA:70967CC BY 4.0Reference data
3-sulfino-L-alanine+L-aspartate3-sulfino-L-alanine+L-aspartate
Transported by SLC25A12 or SLC25A13
Reaction pageDirection not assertedBalanced
Rhea RHEA:70975CC BY 4.0Reference data