Compound
propionyl-CoA
An acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of propionic acid.
Definition from ChEBI (CHEBI:15539), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
26 entities
26 entities reached.
0 reported hops26 assembled from the scaffold
- FASNProteinUNIPROT:P49327substrate ofInferred only59 paths59 endpoints
- ACAT1ProteinUNIPROT:P24752substrate ofInferred only39 paths39 endpoints
- CPT1AProteinUNIPROT:P50416substrate ofInferred only28 paths28 endpoints
- ACSS2ProteinUNIPROT:Q9NR19substrate ofInferred only26 paths13 endpoints
- ACOT2ProteinUNIPROT:P49753substrate ofInferred only22 paths22 endpoints
- SCP2ProteinUNIPROT:P22307substrate ofInferred only21 paths21 endpoints
- CRATProteinUNIPROT:P43155substrate ofInferred only20 paths10 endpoints
- ACSS3ProteinUNIPROT:Q9H6R3substrate ofInferred only20 paths10 endpoints
- PCCBProteinUNIPROT:P05166substrate ofInferred only19 paths19 endpoints
- BAATProteinUNIPROT:Q14032substrate ofInferred only19 paths19 endpoints
- PCCAProteinUNIPROT:P05165substrate ofInferred only18 paths18 endpoints
- ACSS1ProteinUNIPROT:Q9NUB1substrate ofInferred only18 paths9 endpoints
Show the remaining 14
- ACOT8ProteinUNIPROT:O14734substrate ofInferred only16 paths16 endpoints
- CPT2ProteinUNIPROT:P23786substrate ofInferred only15 paths15 endpoints
- GLYATProteinUNIPROT:Q6IB77substrate ofInferred only15 paths15 endpoints
- ACOT7ProteinUNIPROT:O00154substrate ofInferred only12 paths6 endpoints
- ACADSProteinUNIPROT:P16219substrate ofInferred only11 paths11 endpoints
- ACADSBProteinUNIPROT:P45954substrate ofInferred only10 paths10 endpoints
- ACOT4ProteinUNIPROT:Q8N9L9substrate ofInferred only9 paths9 endpoints
- BCAP31ProteinUNIPROT:P51572transported byInferred only8 paths8 endpoints
- ACOT1ProteinUNIPROT:Q86TX2substrate ofInferred only8 paths8 endpoints
- CPT1BProteinUNIPROT:Q92523substrate ofInferred only8 paths8 endpoints
- ABCD1ProteinUNIPROT:P33897transported byInferred only7 paths7 endpoints
- ACOT9ProteinUNIPROT:Q9Y305substrate ofInferred only7 paths7 endpoints
- CPT1CProteinUNIPROT:Q8TCG5substrate ofInferred only4 paths4 endpoints
- IDH3GProteinUNIPROT:P51553transported byInferred only1 path1 endpoint
What the reference databases state
Chemical structure
- propionyl-CoA has the functional parent propionic acidCompoundChEBI CHEBI:15539Inferred only
Statements
50 statements
50 statements · 1 reference database · Subject: propionyl-CoA · Sources: Human-GEM
- propionyl-CoA is converted to (S)-methylmalonyl-CoACompoundHuman-GEM MAR03208Inferred only
- (S)-methylmalonyl-CoA is converted to propionyl-CoACompoundHuman-GEM MAR01521Inferred only
- (S)-methylmalonyl-CoA is converted to propionyl-CoACompoundHuman-GEM MAR01522Inferred only
- (S)-methylmalonyl-CoA is converted to propionyl-CoACompoundHuman-GEM MAR08787Inferred only
- propionyl-CoA is converted to acryloyl-CoACompoundHuman-GEM MAR03212Inferred only
- propionyl-CoA is converted to CHEBI:1146900CompoundHuman-GEM MAR11486Inferred only
- propionyl-CoA is converted to CHEBI:1146900CompoundHuman-GEM MAR02227Inferred only
- CHEBI:1146900 is converted to propionyl-CoACompoundHuman-GEM MAR00755Inferred only
- CHEBI:1146900 is converted to propionyl-CoACompoundHuman-GEM MAR06472Inferred only
- propionyl-CoA is converted to CHEBI:1146900CompoundHuman-GEM MAR04331Inferred only
- CHEBI:1146900 is converted to propionyl-CoACompoundHuman-GEM MAR03205Inferred only
- CHEBI:1146900 is converted to propionyl-CoACompoundHuman-GEM MAR03396Inferred only
Show the remaining 38
- CHEBI:1146900 is converted to propionyl-CoACompoundHuman-GEM MAR03515Inferred only
- CHEBI:1146900 is converted to propionyl-CoACompoundHuman-GEM MAR03796Inferred only
- CHEBI:1146900 is converted to propionyl-CoACompoundHuman-GEM MAR04331Inferred only
- CHEBI:1146900 is converted to propionyl-CoACompoundHuman-GEM MAR11486Inferred only
- propionyl-CoA is converted to CHEBI:1146900CompoundHuman-GEM MAR03796Inferred only
- propionyl-CoA is a substrate of ACADSProteinHuman-GEM MAR03212Inferred only
- propionyl-CoA is a substrate of ACADSBProteinHuman-GEM MAR03212Inferred only
- propionyl-CoA is a substrate of ACAT1ProteinHuman-GEM MAR11486Inferred only
- propionyl-CoA is a substrate of ACOT1ProteinHuman-GEM MAR03799Inferred only
- propionyl-CoA is a substrate of ACOT2ProteinHuman-GEM MAR03799Inferred only
- propionyl-CoA is a substrate of ACOT4ProteinHuman-GEM MAR03799Inferred only
- propionyl-CoA is a substrate of ACOT6ProteinHuman-GEM MAR03799Inferred only
- propionyl-CoA is a substrate of ACOT7ProteinHuman-GEM MAR00154Inferred only
- propionyl-CoA is a substrate of ACOT7ProteinHuman-GEM MAR03799Inferred only
- propionyl-CoA is a substrate of ACOT8ProteinHuman-GEM MAR03009Inferred only
- propionyl-CoA is a substrate of ACOT9ProteinHuman-GEM MAR03799Inferred only
- propionyl-CoA is a substrate of ACSS1ProteinHuman-GEM MAR04331Inferred only
- propionyl-CoA is a substrate of ACSS1ProteinHuman-GEM MAR03796Inferred only
- propionyl-CoA is a substrate of ACSS2ProteinHuman-GEM MAR04331Inferred only
- propionyl-CoA is a substrate of ACSS2ProteinHuman-GEM MAR03796Inferred only
- propionyl-CoA is a substrate of ACSS3ProteinHuman-GEM MAR03796Inferred only
- propionyl-CoA is a substrate of ACSS3ProteinHuman-GEM MAR04331Inferred only
- propionyl-CoA is a substrate of BAATProteinHuman-GEM MAR03799Inferred only
- propionyl-CoA is a substrate of CPT1AProteinHuman-GEM MAR02594Inferred only
- propionyl-CoA is a substrate of CPT1BProteinHuman-GEM MAR02594Inferred only
- propionyl-CoA is a substrate of CPT1CProteinHuman-GEM MAR02594Inferred only
- propionyl-CoA is a substrate of CPT2ProteinHuman-GEM MAR02598Inferred only
- propionyl-CoA is a substrate of CRATProteinHuman-GEM MAR03037Inferred only
- propionyl-CoA is a substrate of CRATProteinHuman-GEM MAR02598Inferred only
- propionyl-CoA is a substrate of FASNProteinHuman-GEM MAR02227Inferred only
- propionyl-CoA is a substrate of GLYATProteinHuman-GEM MAR11502Inferred only
- propionyl-CoA is a substrate of PCCAProteinHuman-GEM MAR03208Inferred only
- propionyl-CoA is a substrate of PCCBProteinHuman-GEM MAR03208Inferred only
- propionyl-CoA is a substrate of SCP2ProteinHuman-GEM MAR02950Inferred only
- propionyl-CoA is transported by ABCD1ProteinHuman-GEM MAR03008Inferred only
- propionyl-CoA is transported by BCAP31ProteinHuman-GEM MAR03008Inferred only
- propionyl-CoA is transported by IDH3GProteinHuman-GEM MAR03008Inferred only
- propionyl-CoA is transported by PDZD4ProteinHuman-GEM MAR03008Inferred only
Reactions
57 reactions
ATP+CHEBI:1146900+propionic acidAMP+diphosphate(3-)+propionyl-CoA
Catalysed by ACSS3 or ACSS2 or ACSS1
Reaction pageLeft to rightBalancedEC 6.2.1.17, 6.2.1.1, 3.1.2.2GO:0005829
Human-GEM MAR00153CC BY 4.0Reference data
water+propionyl-CoACHEBI:1146900+proton+propionic acid
Catalysed by ACOT7
Reaction pageLeft to rightBalancedEC 3.1.2.2GO:0005829
Human-GEM MAR00154CC BY 4.0Reference data
6CHEBI:1146900+6FAD+6water+6NAD(+)+MAM02689m6CHEBI:15351+6FADH2+6proton+6NADH(2-)+propionyl-CoA
Reaction pageLeft to rightBalancedEC 1.3.8.7GO:0005759
Human-GEM MAR00755CC BY 4.0Reference data
7CHEBI:1146900+7FAD+7water+heptadecanoyl-CoA+7NAD(+)7CHEBI:15351+7FADH2+7proton+7NADH(2-)+propionyl-CoA
Catalysed by ACADM
Reaction pageLeft to rightBalancedEC 1.3.8.7GO:0005759
Human-GEM MAR00774CC BY 4.0Reference data
proton+(S)-methylmalonyl-CoAcarbon dioxide+propionyl-CoA
Catalysed by MLYCD
Reaction pageLeft to rightBalancedEC 4.1.1.9GO:0005829
Human-GEM MAR01521CC BY 4.0Reference data
proton+(S)-methylmalonyl-CoAcarbon dioxide+propionyl-CoA
Catalysed by MLYCD
Reaction pageLeft to rightBalancedEC 4.1.1.9GO:0005777
Human-GEM MAR01522CC BY 4.0Reference data
3CHEBI:1146900+2FAD+3water+3NAD(+)+pristanoyl-CoACHEBI:15351+2FADH2+5proton+3NADH(2-)+2propionyl-CoA+4,8-dimethylnonanoyl-CoA
Catalysed by ACOX3 & ACAA1 & HSD17B4 & EHHADH
Reaction pageLeft to rightUnbalancedEC 3.1.4.17GO:0005777
Human-GEM MAR01600CC BY 4.0Reference data
3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA+CHEBI:1146900CHEBI:15519+propionyl-CoA
Catalysed by ACAA1 or SCP2 or MYO5B
Reaction pageLeft to rightBalancedEC 2.3.1.176, 2.3.1.16GO:0005777
Human-GEM MAR01652CC BY 4.0Reference data
MAM00754x+CHEBI:1146900CHEBI:28701+propionyl-CoA
Catalysed by ACAA1 or SCP2 or MYO5B
Reaction pageLeft to rightBalancedEC 2.3.1.176GO:0005777
Human-GEM MAR01710CC BY 4.0Reference data
7MAM00755x+3carbon dioxide+8CHEBI:1146900+2water8propionyl-CoA+7MAM03548x
Catalysed by SCP2
Reaction pageLeft to rightBalancedEC 2.7.7.4GO:0005777
Human-GEM MAR01711CC BY 4.0Reference data
MAM00184c+propionyl-CoACHEBI:1146900+MAM02773c
Catalysed by FASN
Reaction pageLeft to rightBalance undeterminableEC 2.3.1.85GO:0005829
Human-GEM MAR02227CC BY 4.0Reference data
(S)-carnitine+propionyl-CoA(S)-carnitine+propionyl-CoA
Reaction pageReversibleBalancedGO:0005759, GO:0005829
Human-GEM MAR02340CC BY 4.0Reference data
Other names
8 names
Resolves to: propionyl-CoA
- Also called
- Propanoyl-CoApropanoyl-coenzyme APropionyl coenzyme APropionyl-coenzyme AS-propanoyl-CoAS-propanoyl-coenzyme AS-Propionylcoenzyme A
- Systematic name
- 3'-phosphoadenosine 5'-(3-{(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-[(3-oxo-3-{[2-(propanoylsulfanyl)ethyl]amino}propyl)amino]butyl} dihydrogen diphosphate)