Compound

15(S)-HPETE

The (S)-enantiomer of 15-HPETE.

Definition from ChEBI (CHEBI:15628), read 2026-09-23. CC BY 4.0.

CHEBI:15628ChEBI

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What it touches on the way

Mechanistic reach

37 entities

37 entities reached.

0 reported hops37 assembled from the scaffold

Show the remaining 25

What the reference databases state

Chemical structure

2-[15(S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoyl]-glycerol has the functional parent 15(S)-HPETECompoundChEBI CHEBI:137187Inferred only

Statements

73 statements

73 statements · 1 reference database · Subject: 15(S)-HPETE · Sources: Human-GEM

Order

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoate is converted to 15(S)-HPETECompoundHuman-GEM MAR03898Inferred only
15(S)-HPETE is converted to (15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateCompoundHuman-GEM MAR03898Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is converted to 15(S)-HPETECompoundHuman-GEM MAR00983Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is converted to 15(S)-HPETECompoundHuman-GEM MAR00985Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is converted to 15(S)-HPETECompoundHuman-GEM MAR00986Inferred only
(5Z,8Z,11Z,14Z)-eicosatetraenoate is converted to 15(S)-HPETECompoundHuman-GEM MAR00987Inferred only
15(S)-HPETE is metabolised by CYP1A1ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP1A1ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP1A2ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP1A2ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP1B1ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP1B1ProteinHuman-GEM MAR00991Inferred only

Show the remaining 61

15(S)-HPETE is metabolised by CYP2A13ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2A13ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2A6ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2A6ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2A7ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2A7ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2B6ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2B6ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2C18ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2C18ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2C19ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2C19ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2C8ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2C8ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2C9ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2C9ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2D6ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2D6ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2E1ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2E1ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2F1ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2F1ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2J2ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2J2ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2S1ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP2S1ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2U1ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP2U1ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP3A4ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP3A4ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP3A43ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP3A43ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP3A5ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP3A5ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP3A7ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP3A7ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP4B1ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP4B1ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP4F11ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP4F11ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP4F12ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP4F12ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP4F8ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP4F8ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is metabolised by CYP4Z1ProteinHuman-GEM MAR00993Inferred only
15(S)-HPETE is metabolised by CYP4Z1ProteinHuman-GEM MAR00991Inferred only
15(S)-HPETE is a substrate of ALOX12ProteinHuman-GEM MAR01010Inferred only
15(S)-HPETE is a substrate of ALOX12ProteinHuman-GEM MAR01011Inferred only
15(S)-HPETE is a substrate of ALOX5ProteinHuman-GEM MAR01015Inferred only
15(S)-HPETE is a substrate of ALOX5ProteinHuman-GEM MAR01018Inferred only
15(S)-HPETE is a substrate of ALOX5ProteinHuman-GEM MAR01017Inferred only
15(S)-HPETE is a substrate of ALOX5ProteinHuman-GEM MAR01016Inferred only
15(S)-HPETE is a substrate of GPX1ProteinHuman-GEM MAR00988Inferred only
15(S)-HPETE is a substrate of GPX2ProteinHuman-GEM MAR00988Inferred only
15(S)-HPETE is a substrate of GPX3ProteinHuman-GEM MAR00988Inferred only
15(S)-HPETE is a substrate of GPX4ProteinHuman-GEM MAR00988Inferred only
15(S)-HPETE is a substrate of GPX5ProteinHuman-GEM MAR00988Inferred only
15(S)-HPETE is a substrate of GPX6ProteinHuman-GEM MAR00988Inferred only
15(S)-HPETE is a substrate of GPX7ProteinHuman-GEM MAR00988Inferred only
15(S)-HPETE is a substrate of GPX8ProteinHuman-GEM MAR00988Inferred only
15(S)-HPETE is a substrate of PRDX6ProteinHuman-GEM MAR00988Inferred only

Reactions

17 reactions

(5Z,8Z,11Z,14Z)-eicosatetraenoate+dioxygen15(S)-HPETE
Catalysed by ALOX15 or ALOX15B
Reaction pageLeft to rightBalancedEC 1.13.11.33cytosol
Human-GEM MAR00983CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoate+dioxygen15(S)-HPETE
Catalysed by ALOX15 or ALOX15B
Reaction pageLeft to rightBalancedEC 1.13.11.33nucleus
Human-GEM MAR00985CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoate+dioxygen15(S)-HPETE
Catalysed by ALOX15 or ALOX15B
Reaction pageLeft to rightBalancedEC 1.13.11.33endoplasmic reticulum
Human-GEM MAR00986CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoate+dioxygen15(S)-HPETE
Catalysed by ALOX15 or ALOX15B
Reaction pageLeft to rightBalancedEC 1.13.11.33peroxisome
Human-GEM MAR00987CC BY 4.0Reference data
(15S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoate+glutathione disulfide+water15(S)-HPETE+2CHEBI:16856
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9cytosol
Human-GEM MAR00988CC BY 4.0Reference data
15(S)-HPETEMAM00390c
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives
Reaction pageReversibleBalancedEC 1.14.14.1cytosol
Human-GEM MAR00991CC BY 4.0Reference data
MAM00296c15(S)-HPETE
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 and 14 more alternatives
Reaction pageReversibleBalancedEC 1.14.14.1cytosol
Human-GEM MAR00993CC BY 4.0Reference data
MAM00365c15(S)-HPETE
Catalysed by ALOX12
Reaction pageReversibleBalancedEC 1.13.11.31cytosol
Human-GEM MAR01010CC BY 4.0Reference data
MAM00365n15(S)-HPETE
Catalysed by ALOX12
Reaction pageReversibleBalancedEC 1.13.11.31nucleus
Human-GEM MAR01011CC BY 4.0Reference data
15(S)-HPETE+dioxygenMAM01058c+hydrogen peroxide
Catalysed by ALOX5
Reaction pageLeft to rightBalancedEC 1.13.11.34cytosol
Human-GEM MAR01015CC BY 4.0Reference data
15(S)-HPETE+dioxygenMAM01058n+hydrogen peroxide
Catalysed by ALOX5
Reaction pageLeft to rightBalancedEC 1.13.11.34nucleus
Human-GEM MAR01016CC BY 4.0Reference data
15(S)-HPETE+dioxygenMAM01058r+hydrogen peroxide
Catalysed by ALOX5
Reaction pageLeft to rightBalancedEC 1.13.11.34endoplasmic reticulum
Human-GEM MAR01017CC BY 4.0Reference data

Show the remaining 5

Other names

8 names

Resolves to: 15(S)-HPETE

Also called: (5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoate(5Z,8Z,11Z,13E)-(15S)-15-Hydroperoxyicosa-5,8,11,13-tetraenoic acid15-Hydroperoxyeicosatetraenoate15-Hydroperoxyeicosatetraenoic acid15-Hydroperoxyicosatetraenoate15-Hydroperoxyicosatetraenoic acid15S-HpETE
Systematic name: (5Z,8Z,11Z,13E,15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoic acid