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Proteins/UNIPROT:P21399
Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA..
Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate..
Function from UniProtKB (P21399), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
53 statements
53 statements · 8 reference databases · Subject: ACO1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
2 reactions
Catalysed by ACO1
Reaction pageReversibleBalancedEC 4.2.1.3cytosol
Human-GEM MAR04454CC BY 4.0Reference data
Reaction pageDirection not assertedBalanced
Rhea RHEA:10336CC BY 4.0Reference data
8 names
Resolves to: ACO1