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Proteins/UNIPROT:P14061
Favors the reduction of estrogens and androgens. Converts estrone (E1) to a more potent estrogen, 17beta-estradiol (E2). Also has 20-alpha-HSD activity. Uses preferentially NADH..
Function from UniProtKB (P14061), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
27 statements
27 statements · 5 reference databases · Subject: HSD17B1 · Sources: Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
8 reactions
androst-4-ene-3,17-dione+proton+NADPH(4-)NADP(3-)+testosterone
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B3 or HSD17B7 or AKR1C3 or HSD17B11 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64cytosol
Human-GEM MAR01973CC BY 4.0Reference data
12 names
Resolves to: HSD17B1
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64endoplasmic reticulum
Human-GEM MAR01974CC BY 4.0Reference data
estrone+proton+NADPH(4-)17beta-estradiol+NADP(3-)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageReversibleBalancedEC 1.1.1.62cytosol
Human-GEM MAR02036CC BY 4.0Reference data
estrone+proton+NADPH(4-)17beta-estradiol+NADP(3-)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageReversibleBalancedEC 1.1.1.62endoplasmic reticulum
Human-GEM MAR02041CC BY 4.0Reference data
estrone+proton+NADH(2-)17beta-estradiol+NAD(+)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64endoplasmic reticulum
Human-GEM MAR07968CC BY 4.0Reference data
testosterone+NADP(3-)androst-4-ene-3,17-dione+NADPH(4-)+hydron
Catalysed by AKR1B15 or HSD17B1 or AKR1C4 or HSD17B3 or AKR1C3 or AKR1C2 or AKR1C1 or DHRS1
Reaction pageRight to leftBalanced
Rhea RHEA:14981CC BY 4.0Reference data