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Proteins/UNIPROT:Q14749
Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine..
Function from UniProtKB (Q14749), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
29 statements
29 statements · 8 reference databases · Subject: GNMT · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
glycine+S-adenosyl-L-methionineproton+CHEBI:16680+CHEBI:15611
Catalysed by GNMT
Reaction pageLeft to rightBalancedEC 2.1.1.20cytosol
Human-GEM MAR03901CC BY 4.0Reference data
glycine+S-adenosyl-L-methioninesarcosine+S-adenosyl-L-homocysteine+hydron
Catalysed by GNMT
1 name
Resolves to: GNMT
Rhea RHEA:19937CC BY 4.0Reference data