17beta-estradiol

1. 17beta-estradiol + 3'-phosphoadenylyl sulfate = 17beta-estradiol 3-sulfate + adenosine 3',5'-bisphosphate + H(+)

Catalysed by SULT1C4, SULT1E1, SULT1A1

1. UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)

Catalysed by UGT1A9, UGT2B11, UGT2B17, UGT2B4 and 16 moreendoplasmic reticulumOne of 2 routes

1. Estradiol-17beta:NADP+ 17-oxidoreductase

Catalysed by HSD17B6, HSD17B1, HSD17B2, HSD17B7 and 3 morecytosolOne of 3 routes

1. ESTRr

No catalyst recordedendoplasmic reticulumOne of 2 routes

1. unspecific monooxygenase (estradiol-17beta)

Catalysed by CYP1A1, CYP1A2, CYP2E1, CYP3A4 and 21 morecytosolOne of 3 routes

1. cytochrome P450 (estradiol-17beta)

Catalysed by CYP3A4cytosolOne of 3 routes

1. 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + UDP + H(+)

Catalysed by UGT2B17, UGT2A1, UGT2B7, UGT1A3 and 1 more

1. 17beta-estradiol + reduced [NADPH--hemoprotein reductase] + O2 = 16beta,17beta-estriol + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP3A4

1. Estradiol-17beta:NADP+ 17-oxidoreductase
2. cytochrome P450 (estrone)

Catalysed by HSD17B6, HSD17B1, HSD17B2, HSD17B7 and 4 morecytosolOne of 4 routes

1. Estradiol-17beta:NADP+ 17-oxidoreductase
2. UDPglucuronate beta-D-glucuronosyltransferase(acceptor-unspecific)

Catalysed by HSD17B6, HSD17B1, HSD17B2, HSD17B7 and 6 more

1. Estradiol-17beta:NADP+ 17-oxidoreductase
2. cytochrome P450 (estrone)
3. S-adenosyl-L-methionine:2-Hydroxyestrone O-methyltransferase

Catalysed by HSD17B6, HSD17B1, HSD17B2, HSD17B7 and 6 morecytosolOne of 3 routes

1. Estradiol-17beta:NADP+ 17-oxidoreductase
2. 3'-Phosphoadenylylsulfate:estrone 3-sulfotransferase
3. transport of estrone 3-sulfate (cytosol to extracellular)