2-methyl-3-oxopropanoic acid

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

302 compounds within 3 steps: 5 in 1, 46 in 2, 251 in 3

One step

pyruvateReach from here →
1. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase
Catalysed by AGXT2mitochondrial matrix
propionyl-CoAReach from here →
1. 2-Methyl-3-oxopropanoate:NAD+ oxidoreductase (CoA-propanoylating)
Catalysed by ALDH6A1mitochondrial matrix
(R)-3-aminoisobutyric acidReach from here →
1. (S)-3-amino-2-methylpropionate transaminase (2-methyl-3-oxopropanoate)
Catalysed by ABAT, AGXT2mitochondrial matrixOne of 2 routes
(R)-methylmalonyl-CoAReach from here →
1. aldehyde dehydrogenase (2-methyl-3-oxopropanoate)
Catalysed by ALDH6A1mitochondrial matrix
(S)-3-amino-2-methylpropanoateReach from here →
1. L-3-amino-isobutanoate:2-oxoglutarate aminotransferase
Catalysed by ABATmitochondrial matrix

Two steps

(S)-carnitineReach from here →
1. 2-Methyl-3-oxopropanoate:NAD+ oxidoreductase (CoA-propanoylating)
2. Active Transport
Catalysed by ALDH6A1mitochondrial matrix, cytosolOne of 2 routes
CHEBI:1146900Reach from here →
1. 2-Methyl-3-oxopropanoate:NAD+ oxidoreductase (CoA-propanoylating)
2. Propanoyl-CoA hydrolase
Catalysed by ALDH6A1, ACOT7mitochondrial matrix, cytosolOne of 13 routes
2-hydroxybutyric acidReach from here →

Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

acetoacetateReach from here →

Catalysed by AGXT2mitochondrial matrix, cytosolOne of 4 routes

acetylpyruvateReach from here →

Catalysed by AGXT2, FAHD1mitochondrial matrix

all-trans-retinoic acidReach from here →

Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

CHEBI:15380Reach from here →

Catalysed by ALDH6A1, MMUTmitochondrial matrix

(S)-malateReach from here →

Catalysed by AGXT2, ME2mitochondrial matrixOne of 2 routes

oxaloacetateReach from here →

Catalysed by AGXT2, PCmitochondrial matrixOne of 3 routes

(S)-lactateReach from here →

Catalysed by AGXT2, LDHA, LDHB, LDHC and 2 moremitochondrial matrix

2-oxobutanoateReach from here →

Catalysed by AGXT2mitochondrial matrix

2-oxoglutaramateReach from here →

Catalysed by AGXT2, KYAT1mitochondrial matrix, cytosolOne of 2 routes

3-fumarylpyruvateReach from here →

Catalysed by AGXT2, FAHD1mitochondrial matrix

(R)-3-hydroxybutyric acidReach from here →

Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

3-hydroxypyruvateReach from here →

Catalysed by AGXT2, AGXTmitochondrial matrix

aceneuramateReach from here →

Catalysed by AGXT2, NPLmitochondrial matrix

5'-deoxyadenosineReach from here →

Catalysed by AGXT2, TYW1B, TYW1mitochondrial matrix

dTDPReach from here →

Catalysed by AGXT2, PKM, PKLRmitochondrial matrix, cytosol

5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by AGXT2mitochondrial matrix

5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by AGXT2mitochondrial matrix

5-(3-methylguanidino)-2-oxopentanoateReach from here →

Catalysed by AGXT2mitochondrial matrix

acetateReach from here →

Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

formic acidReach from here →

Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A7 and 2 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

propionic acidReach from here →

Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 5 routes

butyric acidReach from here →

Catalysed by AGXT2, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, extracellular space, cytosolOne of 2 routes

3-hydroxypyruvic acidReach from here →

Catalysed by AGXT2, AGXTmitochondrial matrix, cytosolOne of 2 routes

3-oxopropanoateReach from here →

Catalysed by AGXT2mitochondrial matrix

D-serineReach from here →

Catalysed by AGXT2, SRRmitochondrial matrix

(R)-lactic acidReach from here →

Catalysed by AGXT2, LDHDmitochondrial matrix, cytosol

(S)-lactic acidReach from here →

Catalysed by AGXT2, LDHB, LDHAL6Bmitochondrial matrixOne of 5 routes

2-iminopropanoateReach from here →

Catalysed by AGXT2, RIDAmitochondrial matrix

phosphoenolpyruvic acidReach from here →

Catalysed by AGXT2, PKM, PKLRmitochondrial matrix, cytosol

N-acetyl-beta-neuraminic acidReach from here →

Catalysed by AGXT2, NPLmitochondrial matrix, cytosol

a 3-acylpyruvateReach from here →

Catalysed by AGXT2, FAHD1mitochondrial matrix

succinyl-CoAReach from here →

Catalysed by ALDH6A1, MMUTmitochondrial matrix

(S)-methylmalonyl-CoAReach from here →

Catalysed by ALDH6A1, PCCA, PCCBmitochondrial matrix

acryloyl-CoAReach from here →

Catalysed by ALDH6A1, ACADS, ACADSBmitochondrial matrix

2-oxo-3-sulfanylpropanoateReach from here →

Catalysed by AGXT2, MPSTmitochondrial matrix

2-methyl-3-oxopropanoateReach from here →

Catalysed by AGXT2mitochondrial matrixOne of 2 routes

L-methionineReach from here →

Catalysed by AGXT2, TYW1B, TYW1mitochondrial matrix

L-alanineReach from here →

Catalysed by ABAT, AGXT2mitochondrial matrixOne of 19 routes

(3S)-citramalyl-CoAReach from here →

Catalysed by AGXT2, CLYBLmitochondrial matrix

5-amino-2-oxopentanoateReach from here →

Catalysed by AGXT2mitochondrial matrix

(4R)-4-hydroxy-2-oxoglutarateReach from here →

Catalysed by AGXT2, HOGA1mitochondrial matrix

(4S)-4-hydroxy-2-oxoglutarateReach from here →

Catalysed by AGXT2, HOGA1mitochondrial matrix