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Proteins/UNIPROT:Q16798
Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+), and is able to reverse the reaction but only with significantly lower efficiency. Can also catalyze the decarboxylation of oxaloacetate into pyruvate (By similarity)..
Function from UniProtKB (Q16798), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
67 statements
67 statements · 5 reference databases · Subject: ME3 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt
4 reactions
(S)-malate+NAD(+)carbon dioxide+NADH(2-)+pyruvate
Reaction pageLeft to rightBalancedEC 1.1.1.38, 1.1.1.39mitochondrial matrix
Human-GEM MAR04087CC BY 4.0Reference data
(S)-malate+NADP(3-)carbon dioxide+NADPH(4-)+pyruvate
Catalysed by
2 names
Resolves to: ME3
Reaction pageLeft to rightBalancedEC 1.1.1.38, 1.1.1.40mitochondrial matrix
Human-GEM MAR04091CC BY 4.0Reference data
oxaloacetate+hydronpyruvate+carbon dioxide
Catalysed by ME2 or ME1 or ME3 or FAHD1
Reaction pageLeft to rightBalanced
Rhea RHEA:15641CC BY 4.0Reference data
(S)-malate+NADP(3-)pyruvate+carbon dioxide+NADPH(4-)
Reaction pageReversibleBalanced
Rhea RHEA:18253CC BY 4.0Reference data