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Proteins/UNIPROT:Q06210
Rate-limiting enzyme of the hexosamine biosynthetic pathway (HBP) that catalyzes the formation of glucosamine-6-phosphate from fructose-6-phosphate and glutamine, thereby controlling the flux of glucose into this pathway. Inhibited by UDP-N-acetylglucosamine (UDP-GlcNAc) through a feedback loop. Fine-tunes the metabolic fluctuations of UDP-GlcNAc and its impacts on hyaluronan synthesis during tissue remodeling. Via control of the HPB, regulates the availability of precursors for N- and O-linked protein glycosylation and modulates peripheral clock oscillation (By similarity)..
Function from UniProtKB (Q06210), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
1 row
273 statements
273 statements · 6 reference databases · Subject: GFPT1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
2 reactions
keto-D-fructose 6-phosphate+L-glutaminealpha-D-glucosamine 6-phosphate+L-glutamate(1-)
Reaction pageLeft to rightBalancedEC 2.6.1.16cytosol
Human-GEM MAR04300CC BY 4.0Reference data
D-fructose 6-phosphate+L-glutamineD-glucosamine 6-phosphate+L-glutamate(1-)
7 names
Resolves to: GFPT1
Reaction pageLeft to rightBalanced
Rhea RHEA:13237CC BY 4.0Reference data