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ferricytochrome c

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

272 compounds within 3 steps: 4 in 1, 72 in 2, 196 in 3

Does it reach a compound?

One step

pyruvateReach from here →
1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
Catalysed by LDHDmitochondrial matrix, cytosolOne of 2 routes
sulfateReach from here →
1. sulfite:ferricytochrome-c oxidoreductase
Catalysed by SUOXmitochondrial matrix, cytosol
ubiquinonesReach from here →
1. ubiquinol:ferricytochrome-c oxidoreductase
Catalysed by UQCRQ, UQCR11, MT-CYB, UQCRH and 6 moremitochondrial intermembrane space, mitochondrial matrix
ferrocytochrome cReach from here →
1. 13(S)-HPODE to 13-oxy-radical-octadecadienoate conversion
No catalyst recordedcytosolOne of 8 routes

Two steps

2-hydroxybutyric acidReach from here →
1. (R)-Lactate:ferricytochrome-c 2-oxidoreductase
2. transport of 2-hydroxybutyrate and pyruvate (cytosol to extracellular)
Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes
pregnenolone sulfateReach from here →
1. sulfite:ferricytochrome-c oxidoreductase
2. Steryl-Sulfatase
Catalysed by SUOX, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

Page 1 of 6

androsterone 3alpha-sulfateReach from here →

sulfite:ferricytochrome-c oxidoreductase
steroid sulfatase (androsterone sulfate)

Catalysed by SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

cholesterol sulfateReach from here →

sulfite:ferricytochrome-c oxidoreductase
Steryl-Sulfatase

Catalysed by SUOX, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

5alpha-dihydrotestosterone sulfateReach from here →

sulfite:ferricytochrome-c oxidoreductase
steroid sulfatase (5-alpha-dihydrotestosterone)

Catalysed by SUOX, STSmitochondrial matrix, cytosolOne of 3 routes

acetoacetateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
transport of acetoacetate and pyruvate (cytosol to mitochondria)

Catalysed by LDHDmitochondrial matrix, cytosolOne of 4 routes

an aryl sulfateReach from here →

sulfite:ferricytochrome-c oxidoreductase
an aryl sulfate + H2O = a phenol + sulfate + H(+)

Catalysed by SUOX, ARSL, ARSF, ARSK and 3 moremitochondrial matrix, cytosol

acetylpyruvateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
acetylpyruvate + H2O = acetate + pyruvate + H(+)

Catalysed by LDHD, FAHD1mitochondrial matrix, cytosol

all-trans-retinoic acidReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
transport of pyruvate and retinoate (cytosol to extracellular)

Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

(S)-malateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
(S)-malate + NAD(+) = pyruvate + CO2 + NADH

Catalysed by LDHD, ME2mitochondrial matrix, cytosolOne of 6 routes

malonateReach from here →

sulfite:ferricytochrome-c oxidoreductase
malonate(in) + sulfate(out) = malonate(out) + sulfate(in)

Catalysed by SUOX, SLC25A14, SLC25A30, SLC25A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

2-methyl-3-oxopropanoic acidReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
(R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

Catalysed by LDHD, AGXT2mitochondrial matrix, cytosol

oxaloacetateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
Pyruvate:carbon-dioxide ligase (ADP-forming)

Catalysed by LDHD, PCmitochondrial matrix, cytosolOne of 3 routes

(S)-lactateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
(S)-lactate + NAD(+) = pyruvate + NADH + H(+)

Catalysed by LDHD, LDHA, LDHB, LDHC and 2 moremitochondrial matrix, cytosol

quinolinic acidReach from here →

sulfite:ferricytochrome-c oxidoreductase
Transport of Quinolinic Acid

Catalysed by SUOX, SLC22A6mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

2-oxobutanoateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
2-oxobutanoate + L-alanine = (2S)-2-aminobutanoate + pyruvate

Catalysed by LDHD, AGXT2mitochondrial matrix, cytosol

2-oxoglutaramateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
L-Glutamine:pyruvate aminotransferase

Catalysed by LDHD, KYAT1mitochondrial matrix, cytosolOne of 2 routes

3-fumarylpyruvateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
3-fumarylpyruvate + H2O = fumarate + pyruvate + H(+)

Catalysed by LDHD, FAHD1mitochondrial matrix, cytosol

oxalic acidReach from here →

sulfite:ferricytochrome-c oxidoreductase
transport of oxalate and sulfate (cytosol to extracellular)

Catalysed by SUOX, SLC26A6mitochondrial matrix, cytosol, extracellular space

(R)-3-hydroxybutyric acidReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
transport of (R)-3-hydroxybutanoate and pyruvate (cytosol to extracellular)

Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

3-hydroxypyruvateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
L-serine + pyruvate = 3-hydroxypyruvate + L-alanine

Catalysed by LDHD, AGXTmitochondrial matrix, cytosol

aceneuramateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
aceneuramate = aldehydo-N-acetyl-D-mannosamine + pyruvate

Catalysed by LDHD, NPLmitochondrial matrix, cytosol

5'-deoxyadenosineReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O

Catalysed by LDHD, TYW1B, TYW1mitochondrial matrix, cytosol

sulfiteReach from here →

sulfite:ferricytochrome-c oxidoreductase
sulfite(in) + sulfate(out) = sulfite(out) + sulfate(in)

Catalysed by SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

3,3'-diiodo-L-thyronine sulfateReach from here →

sulfite:ferricytochrome-c oxidoreductase
Steryl-Sulfatase

Catalysed by SUOX, STSmitochondrial matrix, cytosol, Golgi apparatusOne of 2 routes

ubiquinolReach from here →

ubiquinol:ferricytochrome-c oxidoreductase
thioredoxin-disulfide reductase (NADPH) (ubiquinone)

Catalysed by UQCRQ, UQCR11, MT-CYB, UQCRH and 8 moremitochondrial intermembrane space, mitochondrial matrix, cytosolOne of 6 routes

fumaric acidReach from here →

sulfite:ferricytochrome-c oxidoreductase
transport of fumarate and sulfate (cytosol to mitochondria)

Catalysed by SUOX, SLC25A10mitochondrial matrix, cytosolOne of 3 routes

dTDPReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
pyruvate kinase (dTDP)

Catalysed by LDHD, PKM, PKLRmitochondrial matrix, cytosol

5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
N(omega),N(omega)-dimethyl-L-arginine + pyruvate = 5-(3,3-dimethylguanidino)-2-oxopentanoate + L-alanine

Catalysed by LDHD, AGXT2mitochondrial matrix, cytosol

5-(3,3'-dimethylguanidino)-2-oxopentanoateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
N(omega),N('omega)-dimethyl-L-arginine + pyruvate = 5-(3,3'-dimethylguanidino)-2-oxopentanoate + L-alanine

Catalysed by LDHD, AGXT2mitochondrial matrix, cytosol

5-(3-methylguanidino)-2-oxopentanoateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
N(omega)-methyl-L-arginine + pyruvate = 5-(3-methylguanidino)-2-oxopentanoate + L-alanine

Catalysed by LDHD, AGXT2mitochondrial matrix, cytosol

folic acidReach from here →

sulfite:ferricytochrome-c oxidoreductase
Folate Transport by Oats

Catalysed by SUOX, SLC22A8, SLC22A7mitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

a dicarboxylateReach from here →

sulfite:ferricytochrome-c oxidoreductase
a dicarboxylate(in) + sulfate(out) = a dicarboxylate(out) + sulfate(in)

Catalysed by SUOX, SLC25A35, SLC25A34mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

chlorine(.)Reach from here →

sulfite:ferricytochrome-c oxidoreductase
transport of chloride and sulfate (cytosol to extracellular)

Catalysed by SUOX, SLC26A6mitochondrial matrix, cytosol, extracellular space

D-aspartateReach from here →

sulfite:ferricytochrome-c oxidoreductase
D-aspartate(in) + sulfate(out) = D-aspartate(out) + sulfate(in)

Catalysed by SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

L-aspartateReach from here →

sulfite:ferricytochrome-c oxidoreductase
L-aspartate(in) + sulfate(out) = L-aspartate(out) + sulfate(in)

Catalysed by SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

acetateReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
transport of acetate and pyruvate (cytosol to extracellular)

Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 2 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

oxalateReach from here →

sulfite:ferricytochrome-c oxidoreductase
oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)

Catalysed by SUOX, SLC25A14, SLC26A2, SLC25A30 and 2 moremitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

formic acidReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
transport of formate and pyruvate (cytosol to extracellular)

Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A7 and 2 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

propionic acidReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
transport of propanoate and pyruvate (cytosol to extracellular)

Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

butyric acidReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
transport of butyrate and pyruvate (cytosol to extracellular)

Catalysed by LDHD, SLC16A4, SLC16A5, SLC16A3 and 3 moremitochondrial matrix, cytosol, extracellular spaceOne of 2 routes

maleateReach from here →

sulfite:ferricytochrome-c oxidoreductase
maleate(in) + sulfate(out) = maleate(out) + sulfate(in)

Catalysed by SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

malonic acidReach from here →

sulfite:ferricytochrome-c oxidoreductase
transport of malonate and sulfate (cytosol to mitochondria)

Catalysed by SUOX, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

3-hydroxypyruvic acidReach from here →

(R)-Lactate:ferricytochrome-c 2-oxidoreductase
L-Serine:pyruvate aminotransferase

Catalysed by LDHD, AGXTmitochondrial matrix, cytosolOne of 2 routes

(2R,3R)-tartrateReach from here →

sulfite:ferricytochrome-c oxidoreductase
(2R,3R)-tartrate(in) + sulfate(out) = (2R,3R)-tartrate(out) + sulfate(in)

Catalysed by SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

(S,S)-tartrateReach from here →

sulfite:ferricytochrome-c oxidoreductase
(S,S)-tartrate(in) + sulfate(out) = (S,S)-tartrate(out) + sulfate(in)

Catalysed by SUOX, SLC25A14, SLC25A30mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes