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Proteins/UNIPROT:Q9UJS0
Mitochondrial electrogenic aspartate/glutamate antiporter that favors efflux of aspartate and entry of glutamate and proton within the mitochondria as part of the malate-aspartate shuttle. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. Also mediates the uptake of L-cysteinesulfinate (3-sulfino-L-alanine) by mitochondria in exchange for L-glutamate and proton. Can also exchange L-cysteinesulfinate with aspartate in their anionic form without any proton translocation. Lacks transport activity towards gamma-aminobutyric acid (GABA)..
Function from UniProtKB (Q9UJS0), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
4 rows
205 statements
205 statements · 7 reference databases · Subject: SLC25A13 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
6 reactions
L-aspartate+L-glutamate(1-)+protonL-aspartate+L-glutamate(1-)+proton
Transported by SLC25A13 or SLC25A12
Reaction pageLeft to rightBalancedmitochondrial matrix, cytosol, mitochondrial intermembrane space
Human-GEM MAR03825CC BY 4.0Reference data
3-sulfino-L-alanine+L-aspartate3-sulfino-L-alanine+L-aspartate
7 names
Resolves to: SLC25A13
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR03863CC BY 4.0Reference data
3-sulfino-L-alanine+L-glutamate(1-)+proton3-sulfino-L-alanine+L-glutamate(1-)+proton
Transported by SLC25A13 or SLC25A12
Reaction pageLeft to rightBalancedmitochondrial matrix, cytosol, mitochondrial intermembrane space
Human-GEM MAR03864CC BY 4.0Reference data
L-aspartate+L-glutamate(1-)+hydronL-aspartate+L-glutamate(1-)+hydron
Transported by SLC25A12 or SLC25A13
Reaction pageDirection not assertedBalanced
Rhea RHEA:70783CC BY 4.0Reference data
3-sulfino-L-alanine+L-glutamate(1-)+hydron3-sulfino-L-alanine+L-glutamate(1-)+hydron
Transported by SLC25A12 or SLC25A13
Reaction pageDirection not assertedBalanced
Rhea RHEA:70967CC BY 4.0Reference data
3-sulfino-L-alanine+L-aspartate3-sulfino-L-alanine+L-aspartate
Transported by SLC25A12 or SLC25A13
Reaction pageDirection not assertedBalanced
Rhea RHEA:70975CC BY 4.0Reference data