D-threo-isocitrate

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

34 compounds within 3 steps: 1 in 1, 11 in 2, 22 in 3

One step

citric acidReach from here →
1. citrate = D-threo-isocitrate
Catalysed by ACO1, ACO2One of 3 routes

Two steps

(S)-malateReach from here →
1. citrate = D-threo-isocitrate
2. Citrate Transport, Mitochondrial
Catalysed by ACO1, ACO2, SLC25A1mitochondrial matrix, cytosolOne of 5 routes
trans-aconitateReach from here →
1. citrate = D-threo-isocitrate
2. trans-aconitate(in) + citrate(out) = trans-aconitate(out) + citrate(in)
Catalysed by ACO1, ACO2, SLC25A1inner side of the membrane, outer side of the membraneOne of 2 routes
cis-aconitateReach from here →
1. citrate = D-threo-isocitrate
2. cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)
Catalysed by ACO1, ACO2, SLC25A1inner side of the membrane, outer side of the membraneOne of 2 routes
oxaloacetateReach from here →
1. citrate = D-threo-isocitrate
2. ATP citrate lyase (citrate)
Catalysed by ACO1, ACO2, ACLYcytosolOne of 3 routes
oxalic acidReach from here →
1. citrate = D-threo-isocitrate
2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
Catalysed by ACO1, ACO2, SLC25A1mitochondrial matrix, cytosolOne of 3 routes
maleateReach from here →
1. citrate = D-threo-isocitrate
2. maleate(in) + citrate(out) = maleate(out) + citrate(in)
Catalysed by ACO1, ACO2, SLC25A1inner side of the membrane, outer side of the membraneOne of 2 routes
isocitric acidReach from here →
1. citrate = D-threo-isocitrate
2. citrate hydroxymutase
Catalysed by ACO1, ACO2cytosolOne of 3 routes
cis-aconitic acidReach from here →
1. citrate = D-threo-isocitrate
2. citrate hydro-lyase (cis-aconitate-forming)
Catalysed by ACO1, ACO2mitochondrial matrixOne of 3 routes
phosphoenolpyruvic acidReach from here →
1. citrate = D-threo-isocitrate
2. transport of citrate and PEP (cytosol to mitochondria)
Catalysed by ACO1, ACO2, SLC25A1mitochondrial matrix, cytosolOne of 2 routes
phosphoenolpyruvateReach from here →
1. citrate = D-threo-isocitrate
2. phosphoenolpyruvate(in) + citrate(out) = phosphoenolpyruvate(out) + citrate(in)
Catalysed by ACO1, ACO2, SLC25A1inner side of the membrane, outer side of the membraneOne of 2 routes
beta-citrylglutamateReach from here →
1. citrate = D-threo-isocitrate
2. citrate + L-glutamate + ATP = beta-citrylglutamate + ADP + phosphate + H(+)
Catalysed by ACO1, ACO2, RIMKLB

Three steps

CHEBI:1146900Reach from here →
Catalysed by ACO1, ACO2, ACLY, CScytosol, mitochondrial matrixOne of 2 routes
pyruvateReach from here →
Catalysed by and 1 more

ACO1

, ACO2

, SLC25A1

, ME2

mitochondrial matrix, cytosol

One of 17 routes

malonateReach from here →

Catalysed by ACO1, ACO2, SLC25A1, SLC25A10mitochondrial matrix, cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

sulfateReach from here →

Catalysed by ACO1, ACO2, SLC25A1, SLC25A10mitochondrial matrix, cytosolOne of 7 routes

CHEBI:16284Reach from here →

Catalysed by ACO1, ACO2, SLC25A1, PKM and 1 moremitochondrial matrix, cytosol

CHEBI:16497Reach from here →

Catalysed by ACO1, ACO2, SLC25A1, PKM and 1 moremitochondrial matrix, cytosol

itaconateReach from here →

Catalysed by ACO1, ACO2, ACOD1mitochondrial matrixOne of 2 routes

sulfiteReach from here →

Catalysed by ACO1, ACO2, SLC25A1, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

enol-oxaloacetateReach from here →

Catalysed by ACO1, ACO2, SLC25A1, SDHB and 1 moremitochondrial matrix, cytosol

fumaric acidReach from here →

Catalysed by ACO1, ACO2, SLC25A1, FHmitochondrial matrix, cytosolOne of 5 routes

dTTPReach from here →

Catalysed by ACO1, ACO2, SLC25A1, PKM and 1 moremitochondrial matrix, cytosol

5-(3,3-dimethylguanidino)-2-oxopentanoateReach from here →

Catalysed by ACO1, ACO2, ACLY, AGXT2cytosol

N-acetylneuraminate 9-phosphateReach from here →

Catalysed by ACO1, ACO2, SLC25A1, NANSmitochondrial matrix, cytosolOne of 2 routes

a quinolReach from here →

Catalysed by ACO1, ACO2, SLC25A1, SDHB and 1 moremitochondrial matrix, cytosol

chlorine(.)Reach from here →

Catalysed by ACO1, ACO2, SLC25A1, SLC26A6mitochondrial matrix, cytosol, extracellular space

L-aspartateReach from here →

Catalysed by ACO1, ACO2, ACLY, GOT2cytosol, mitochondrial matrixOne of 5 routes

4-hydroxy-2-oxoglutaric acidReach from here →

Catalysed by ACO1, ACO2, ACLY, GOT2cytosol, mitochondrial matrix

thiosulfateReach from here →

Catalysed by ACO1, ACO2, SLC25A1, SLC25A10mitochondrial matrix, cytosolOne of 2 routes

glyoxylateReach from here →

Catalysed by ACO1, ACO2, SLC25A1, CLYBLmitochondrial matrix, cytosol

(S)-malyl-CoAReach from here →

Catalysed by ACO1, ACO2, SLC25A1, SUCLG1 and 1 moremitochondrial matrix, cytosol

(2R)-2-phosphoglycerateReach from here →

Catalysed by ACO1, ACO2, SLC25A1, ENO1 and 2 moremitochondrial matrix, cytosolOne of 2 routes

3-deoxy-D-glycero-beta-D-galacto-non-2-ulopyranosonate 9-phosphateReach from here →

Catalysed by ACO1, ACO2, SLC25A1, NANSinner side of the membrane, outer side of the membrane