androst-4-ene-3,17-dione

1. androst-4-ene-3,17-dione + 3 reduced [NADPH--hemoprotein reductase] + 3 O2 = estrone + formate + 3 oxidized [NADPH--hemoprotein reductase] + 4 H2O + 4 H(+)

Catalysed by CYP19A1

1. 5alpha-androstane-3,17-dione:NADP+ delta4-oxidoreductase

Catalysed by AKR1D1cytosolOne of 3 routes

1. androst-4-ene-3,17-dione + NADPH + H(+) = 5beta-androstane-3,17-dione + NADP(+)

Catalysed by AKR1D1

1. cytochrome P450 (17alpha-hydroxyprogesterone)

Catalysed by CYP17A1endoplasmic reticulum

1. cytochrome P450 (4-androstene-3,17-dione)

Catalysed by CYP19A1endoplasmic reticulumOne of 2 routes

1. testosterone:NADP+ 17-oxidoreductase

Catalysed by HSD17B6, HSD17B1, HSD17B3, HSD17B2 and 4 morecytosolOne of 4 routes

1. 19-hydroxyandrostenedione,NADPH-hemoprotein reductase:oxygen 19-oxidoreductase

Catalysed by CYP19A1cytosolOne of 2 routes

1. androst-4-ene-3,17-dione + reduced [NADPH--hemoprotein reductase] + O2 = 16alpha-hydroxyandrost-4-ene-3,17-dione + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP17A1

1. androst-4-ene-3,17-dione + 2 reduced [adrenodoxin] + O2 + 2 H(+) = 11beta-hydroxyandrost-4-ene-3,17-dione + 2 oxidized [adrenodoxin] + H2O

Catalysed by CYP11B1

1. cytochrome P450 (4-androstene-3,17-dione)

Catalysed by CYP19A1endoplasmic reticulum

1. androst-4-ene-3,17-dione + reduced [NADPH--hemoprotein reductase] + O2 = 6beta-hydroxyandrost-4-ene-3,17-dione + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)

Catalysed by CYP3A4, CYP3A5

1. cytochrome P450 (4-androstene-3,17-dione)
2. transport of 2-hydroxybutyrate and formate (cytosol to extracellular)

Catalysed by CYP19A1, SLC16A4, SLC16A5, SLC16A7 and 1 moreendoplasmic reticulum, extracellular space, cytosolOne of 2 routes

1. cytochrome P450 (4-androstene-3,17-dione)
2. cytochrome P450 (estrone)

Catalysed by CYP19A1, CYP3A4endoplasmic reticulum, cytosolOne of 4 routes