Compound
17beta-estradiol
No description recorded for this entry yet. Everything this graph holds about 17beta-estradiol is below.
Structure
- Class
- Organic compound
- Formula
- C18H24O2
- Mass
- 272.388 g/mol
- Charge
- 0
- InChIKey
- VOXZDWNPVJITMN-ZBRFXRBCSA-N
- SMILES
- [H][C@@]12CCc3cc(O)ccc3[C@@]1([H])CC[C@]1(C)[C@@H](O)CC[C@@]21[H]
- Look it up
- ChEBIBy InChIKey
Identity from ChEBI. Not evidence — none of it carries a grade.
What it touches on the way
A finding says 17beta-estradiol moved an endpoint. This is the biology in between: the proteins and reactions it runs through to get there. It is where to look for the two things a list of findings cannot answer — why a result might happen, and what else acts on the same machinery.
28 of these are proteins with a page of their own, and that is the door: a protein page says what else it carries, which is how one compound leads to the next.
Mechanistic reach
28 entities
28 entities reached, most connected first. Hub metabolites are excluded, so this is not a claim that the compound touches everything.
0 reported hops28 assembled from the scaffold
- AKR1C3ProteinUNIPROT:P42330substrate ofInferred only62 paths31 endpoints
- AKR1C1ProteinUNIPROT:Q04828substrate ofInferred only46 paths23 endpoints
- AKR1C4ProteinUNIPROT:P17516substrate ofInferred only42 paths21 endpoints
- AKR1C2ProteinUNIPROT:P52895substrate ofInferred only32 paths16 endpoints
- HSD17B1ProteinUNIPROT:P14061substrate ofInferred only30 paths15 endpoints
- UGT1A3ProteinUNIPROT:P35503metabolized byInferred only30 paths15 endpoints
- UGT1A10ProteinUNIPROT:Q9HAW8metabolized byInferred only28 paths14 endpoints
- CYP19A1ProteinUNIPROT:P11511metabolized byInferred only25 paths25 endpoints
- UGT1A1ProteinUNIPROT:P22309metabolized byInferred only25 paths25 endpoints
- HSD17B12ProteinUNIPROT:Q53GQ0substrate ofInferred only24 paths12 endpoints
- HSD17B10ProteinUNIPROT:Q99714substrate ofInferred only17 paths17 endpoints
- UGT2A1ProteinUNIPROT:P0DTE4metabolized byInferred only16 paths8 endpoints
Show the remaining 16
- UGT2B7ProteinUNIPROT:P16662metabolized byInferred only16 paths16 endpoints
- HSD17B3ProteinUNIPROT:P37058substrate ofInferred only16 paths16 endpoints
- SULT1A1ProteinUNIPROT:P50225metabolized byInferred only16 paths16 endpoints
- SULT1E1ProteinUNIPROT:P49888metabolized byInferred only13 paths13 endpoints
- HSD17B7ProteinUNIPROT:P56937substrate ofInferred only13 paths13 endpoints
- HSD17B2ProteinUNIPROT:P37059substrate ofInferred only12 paths12 endpoints
- UGT1A8ProteinUNIPROT:Q9HAW9metabolized byInferred only11 paths11 endpoints
- HSD17B11ProteinUNIPROT:Q8NBQ5substrate ofInferred only10 paths5 endpoints
- UGT2B17ProteinUNIPROT:O75795metabolized byInferred only9 paths9 endpoints
- UGT2A2ProteinUNIPROT:P0DTE5metabolized byInferred only9 paths9 endpoints
- HSD17B6ProteinUNIPROT:O14756substrate ofInferred only8 paths4 endpoints
- SULT1C4ProteinUNIPROT:O75897metabolized byInferred only8 paths8 endpoints
- AKR1B15ProteinUNIPROT:C9JRZ8substrate ofInferred only5 paths5 endpoints
- HSD17B8ProteinUNIPROT:Q92506substrate ofInferred only5 paths5 endpoints
- HSD17B13ProteinUNIPROT:Q7Z5P4substrate ofInferred only3 paths3 endpoints
- DHRS11ProteinUNIPROT:Q6UWP2substrate ofInferred only1 path1 endpoint
What the reference databases state
The section above shows paths a projection assembled. This is the reference layer itself, one step from 17beta-estradiol: what the cleared databases state it reacts with, is carried by, is converted to and takes part in, whether or not a projection has walked it yet.
Regulatory determinations
Published numbers and scores, transcribed from the body that issued them. A determination is not a finding and is not graded; it is the number, who set it, and the document it came from.
LiverTox likelihood score ALiverTox
LiverTox Likelihood Score A — well known, well described and well reported to cause liver injury. Chapter: "Estrogens and OCs". Source: LiverTox Master List (NBK571102).
The document·Public Domain (NLM/NIH)·Transcribed, not graded
Statements
43 statements
43 statements in 1 reference database name 17beta-estradiol — Rhea. Press a relation to see only its rows; every count is the rows behind it.
- 17beta-estradiol is converted to estroneCompoundRhea RHEA:24612Inferred only
- estrone is converted to 17beta-estradiolCompoundRhea RHEA:24616Inferred only
- 17beta-estradiol is converted to estroneCompoundRhea RHEA:24616Inferred only
- estrone is converted to 17beta-estradiolCompoundRhea RHEA:24612Inferred only
- 17beta-estradiol is metabolised by CYP19A1ProteinRhea RHEA:38191Inferred only
- 17beta-estradiol is metabolised by SULT1A1ProteinRhea RHEA:52372Inferred only
- 17beta-estradiol is metabolised by SULT1C4ProteinRhea RHEA:52372Inferred only
- 17beta-estradiol is metabolised by SULT1E1ProteinRhea RHEA:52372Inferred only
- 17beta-estradiol is metabolised by UGT1A1ProteinRhea RHEA:52460Inferred only
- 17beta-estradiol is metabolised by UGT1A10ProteinRhea RHEA:52460Inferred only
- 17beta-estradiol is metabolised by UGT1A10ProteinRhea RHEA:52464Inferred only
- 17beta-estradiol is metabolised by UGT1A3ProteinRhea RHEA:52460Inferred only
Show the remaining 31
- 17beta-estradiol is metabolised by UGT1A3ProteinRhea RHEA:52464Inferred only
- 17beta-estradiol is metabolised by UGT1A8ProteinRhea RHEA:52460Inferred only
- 17beta-estradiol is metabolised by UGT2A1ProteinRhea RHEA:52464Inferred only
- 17beta-estradiol is metabolised by UGT2A1ProteinRhea RHEA:52460Inferred only
- 17beta-estradiol is metabolised by UGT2A2ProteinRhea RHEA:52460Inferred only
- 17beta-estradiol is metabolised by UGT2B17ProteinRhea RHEA:52464Inferred only
- 17beta-estradiol is metabolised by UGT2B7ProteinRhea RHEA:52464Inferred only
- 17beta-estradiol is a substrate of AKR1B15ProteinRhea RHEA:24616Inferred only
- 17beta-estradiol is a substrate of AKR1C1ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of AKR1C1ProteinRhea RHEA:24616Inferred only
- 17beta-estradiol is a substrate of AKR1C2ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of AKR1C2ProteinRhea RHEA:24616Inferred only
- 17beta-estradiol is a substrate of AKR1C3ProteinRhea RHEA:24616Inferred only
- 17beta-estradiol is a substrate of AKR1C3ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of AKR1C4ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of AKR1C4ProteinRhea RHEA:24616Inferred only
- 17beta-estradiol is a substrate of DHRS11ProteinRhea RHEA:24616Inferred only
- 17beta-estradiol is a substrate of HSD17B1ProteinRhea RHEA:24616Inferred only
- 17beta-estradiol is a substrate of HSD17B1ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B10ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B11ProteinRhea RHEA:24616Inferred only
- 17beta-estradiol is a substrate of HSD17B11ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B12ProteinRhea RHEA:24616Inferred only
- 17beta-estradiol is a substrate of HSD17B12ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B13ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B2ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B3ProteinRhea RHEA:24616Inferred only
- 17beta-estradiol is a substrate of HSD17B6ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B6ProteinRhea RHEA:24616Inferred only
- 17beta-estradiol is a substrate of HSD17B7ProteinRhea RHEA:24616Inferred only
- 17beta-estradiol is a substrate of HSD17B8ProteinRhea RHEA:24612Inferred only
Other names
17 names
Every name this graph resolves to 17beta-estradiol. Searching any of them lands here.
- Also called
- (17beta)-estra-1,3,5(10)-triene-3,17-diol(17β)-estra-1,3,5(10)-triene-3,17-diol17b-Oestradiol17beta oestradiol17beta-estra-1,3,5(10)-triene-3,17-diol17beta-oestradiol17β-estra-1,3,5(10)-triene-3,17-diol17β-estradiol17β-oestradiol3,17b-Dihydroxyestra-1,3,5(10)-trienebeta-Estradiolcis-estradiolESTRADIOLEstradiol-17betaST 18:3;O2
- Systematic name
- estra-1,3,5(10)-triene-3,17beta-diolestra-1,3,5(10)-triene-3,17β-diol