Compound
17beta-estradiol
The 17-beta-isomer of estradiol, an aromatized C18 steroid with hydroxyl group at 3-beta- and 17-beta-position. Estradiol-17-beta is the most potent form of mammalian estrogenic steroids.
CHEBI:16469ChEBI
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C18H24O2
- Mass
- 272.388 g/mol
- Charge
- 0
- InChIKey
- VOXZDWNPVJITMN-ZBRFXRBCSA-N
- SMILES
- [H][C@@]12CCc3cc(O)ccc3[C@@]1([H])CC[C@]1(C)[C@@H](O)CC[C@@]21[H]
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
40 entities
40 entities reached.
0 reported hops40 assembled from the scaffold
- CYP3A4ProteinUNIPROT:P08684metabolized byInferred only307 paths39 endpoints
- CYP1A1ProteinUNIPROT:P04798metabolized byInferred only125 paths21 endpoints
- CYP1A2ProteinUNIPROT:P05177metabolized byInferred only124 paths31 endpoints
- CYP2C9ProteinUNIPROT:P11712metabolized byInferred only92 paths31 endpoints
- CYP2C8ProteinUNIPROT:P10632metabolized byInferred only86 paths29 endpoints
- CYP1B1ProteinUNIPROT:Q16678metabolized byInferred only80 paths20 endpoints
- CYP2E1ProteinUNIPROT:P05181metabolized byInferred only68 paths34 endpoints
- CYP2B6ProteinUNIPROT:P20813metabolized byInferred only54 paths18 endpoints
- CYP19A1ProteinUNIPROT:P11511metabolized byInferred only52 paths26 endpoints
- HSD17B1ProteinUNIPROT:P14061substrate ofInferred only45 paths15 endpoints
- HSD17B12ProteinUNIPROT:Q53GQ0substrate ofInferred only39 paths13 endpoints
- CYP2A6ProteinUNIPROT:P11509metabolized byInferred only36 paths18 endpoints
Show the remaining 28
- CYP3A7ProteinUNIPROT:P24462metabolized byInferred only36 paths10 endpoints
- CYP2C19ProteinUNIPROT:P33261metabolized byInferred only36 paths18 endpoints
- HSD17B2ProteinUNIPROT:P37059substrate ofInferred only36 paths12 endpoints
- AKR1C3ProteinUNIPROT:P42330substrate ofInferred only35 paths35 endpoints
- CYP3A5ProteinUNIPROT:P20815metabolized byInferred only34 paths10 endpoints
- HSD17B7ProteinUNIPROT:P56937substrate ofInferred only34 paths17 endpoints
- HSD17B10ProteinUNIPROT:Q99714substrate ofInferred only33 paths33 endpoints
- UGT1A10ProteinUNIPROT:Q9HAW8metabolized byInferred only33 paths11 endpoints
- UGT1A1ProteinUNIPROT:P22309metabolized byInferred only32 paths16 endpoints
- CYP2D6ProteinUNIPROT:P10635metabolized byInferred only30 paths15 endpoints
- UGT1A3ProteinUNIPROT:P35503metabolized byInferred only26 paths10 endpoints
- AKR1C1ProteinUNIPROT:Q04828substrate ofInferred only25 paths25 endpoints
- SULT1E1ProteinUNIPROT:P49888metabolized byInferred only24 paths24 endpoints
- UGT1A4ProteinUNIPROT:P22310metabolized byInferred only23 paths23 endpoints
- CYP2A13ProteinUNIPROT:Q16696metabolized byInferred only22 paths11 endpoints
- CYP4B1ProteinUNIPROT:P13584metabolized byInferred only22 paths11 endpoints
- AKR1C4ProteinUNIPROT:P17516substrate ofInferred only21 paths21 endpoints
- CYP4F12ProteinUNIPROT:Q9HCS2metabolized byInferred only20 paths10 endpoints
- UGT1A9ProteinUNIPROT:O60656metabolized byInferred only19 paths19 endpoints
- UGT2A1ProteinUNIPROT:P0DTE4metabolized byInferred only19 paths8 endpoints
- UGT2B7ProteinUNIPROT:P16662metabolized byInferred only19 paths10 endpoints
- UGT1A8ProteinUNIPROT:Q9HAW9metabolized byInferred only18 paths9 endpoints
- UGT2B17ProteinUNIPROT:O75795metabolized byInferred only18 paths9 endpoints
- CYP2A7ProteinUNIPROT:P20853metabolized byInferred only18 paths9 endpoints
- CYP2F1ProteinUNIPROT:P24903metabolized byInferred only18 paths9 endpoints
- AKR1C2ProteinUNIPROT:P52895substrate ofInferred only16 paths16 endpoints
- CYP2U1ProteinUNIPROT:Q7Z449metabolized byInferred only15 paths15 endpoints
- HSD17B11ProteinUNIPROT:Q8NBQ5substrate ofInferred only15 paths5 endpoints
What the reference databases state
Regulatory determinations
LiverTox likelihood score ALiverTox
LiverTox Likelihood Score A — well known, well described and well reported to cause liver injury. Chapter: "Estrogens and OCs". Source: LiverTox Master List (NBK571102).
The document·Public Domain (NLM/NIH)·Transcribed, not assessed
Chemical structure
- 16beta,17beta-estriol has the functional parent 17beta-estradiolCompoundChEBI CHEBI:87620Inferred only
- 17alpha-ethynylestradiol has the functional parent 17beta-estradiolCompoundChEBI CHEBI:4903Inferred only
- 2-hydroxy-17beta-estradiol has the functional parent 17beta-estradiolCompoundChEBI CHEBI:28744Inferred only
- 2-hydroxy-3-methoxy-17beta-estradiol has the functional parent 17beta-estradiolCompoundChEBI CHEBI:89268Inferred only
- 2-methoxy-17beta-estradiol has the functional parent 17beta-estradiolCompoundChEBI CHEBI:28955Inferred only
- 4-hydroxy-17beta-estradiol has the functional parent 17beta-estradiolCompoundChEBI CHEBI:62845Inferred only
- 4-methoxy-17beta-estradiol has the functional parent 17beta-estradiolCompoundChEBI CHEBI:136975Inferred only
Statements
149 statements
149 statements · 2 reference databases · Subject: 17beta-estradiol · Sources: Human-GEM, Rhea
- 17beta-estradiol is converted to 16alpha,17beta-estriolCompoundHuman-GEM MAR11368Inferred only
- 17beta-estradiol is converted to 17beta-estradiol 17-O-(beta-D-glucuronate)CompoundRhea RHEA:52464Inferred only
- 17beta-estradiol is converted to 17beta-estradiol 3-O-(beta-D-glucuronate)CompoundRhea RHEA:52460Inferred only
- 17beta-estradiol is converted to 17beta-estradiol 3-O-(beta-D-glucuronate)CompoundHuman-GEM MAR07648Inferred only
- 17beta-estradiol is converted to 17beta-estradiol 3-sulfateCompoundRhea RHEA:52372Inferred only
- 17beta-estradiol is converted to 2-hydroxy-17beta-estradiolCompoundHuman-GEM MAR02042Inferred only
- 17beta-estradiol is converted to 2-hydroxy-17beta-estradiolCompoundHuman-GEM MAR02043Inferred only
- 17beta-estradiol is converted to 4-hydroxy-17beta-estradiolCompoundHuman-GEM MAR02046Inferred only
- 17beta-estradiol is converted to 4-hydroxy-17beta-estradiolCompoundHuman-GEM MAR02047Inferred only
- estrone is converted to 17beta-estradiolCompoundHuman-GEM MAR02036Inferred only
- estrone is converted to 17beta-estradiolCompoundHuman-GEM MAR02041Inferred only
- 17beta-estradiol is converted to estroneCompoundHuman-GEM MAR02036Inferred only
Show the remaining 137
- 17beta-estradiol is converted to estroneCompoundRhea RHEA:24612Inferred only
- estrone is converted to 17beta-estradiolCompoundRhea RHEA:24616Inferred only
- 17beta-estradiol is converted to estroneCompoundHuman-GEM MAR02041Inferred only
- estrone is converted to 17beta-estradiolCompoundRhea RHEA:24612Inferred only
- estrone is converted to 17beta-estradiolCompoundHuman-GEM MAR07968Inferred only
- 17beta-estradiol is metabolised by CYP19A1ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP19A1ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP1A1ProteinRhea RHEA:47212Inferred only
- 17beta-estradiol is metabolised by CYP1A1ProteinRhea RHEA:47276Inferred only
- 17beta-estradiol is metabolised by CYP1A1ProteinRhea RHEA:47280Inferred only
- 17beta-estradiol is metabolised by CYP1A1ProteinRhea RHEA:47284Inferred only
- 17beta-estradiol is metabolised by CYP1A1ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP1A1ProteinRhea RHEA:47288Inferred only
- 17beta-estradiol is metabolised by CYP1A1ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP1A2ProteinRhea RHEA:47212Inferred only
- 17beta-estradiol is metabolised by CYP1A2ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP1A2ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP1A2ProteinRhea RHEA:47280Inferred only
- 17beta-estradiol is metabolised by CYP1B1ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP1B1ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP1B1ProteinRhea RHEA:47280Inferred only
- 17beta-estradiol is metabolised by CYP1B1ProteinRhea RHEA:47212Inferred only
- 17beta-estradiol is metabolised by CYP2A13ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP2A13ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP2A6ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP2A6ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP2A7ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP2A7ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP2B6ProteinRhea RHEA:47212Inferred only
- 17beta-estradiol is metabolised by CYP2B6ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP2B6ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP2C18ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP2C19ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP2C19ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP2C8ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP2C8ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP2C8ProteinRhea RHEA:47332Inferred only
- 17beta-estradiol is metabolised by CYP2C9ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP2C9ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP2C9ProteinRhea RHEA:47212Inferred only
- 17beta-estradiol is metabolised by CYP2D6ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP2D6ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP2E1ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP2E1ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP2F1ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP2F1ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP2J2ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP2S1ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP2S1ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP2U1ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP3A4ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP3A4ProteinRhea RHEA:47212Inferred only
- 17beta-estradiol is metabolised by CYP3A4ProteinHuman-GEM MAR02047Inferred only
- 17beta-estradiol is metabolised by CYP3A4ProteinRhea RHEA:47332Inferred only
- 17beta-estradiol is metabolised by CYP3A4ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP3A4ProteinHuman-GEM MAR02046Inferred only
- 17beta-estradiol is metabolised by CYP3A4ProteinRhea RHEA:47336Inferred only
- 17beta-estradiol is metabolised by CYP3A4ProteinRhea RHEA:47280Inferred only
- 17beta-estradiol is metabolised by CYP3A43ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP3A43ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP3A5ProteinRhea RHEA:47212Inferred only
- 17beta-estradiol is metabolised by CYP3A5ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP3A5ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP3A5ProteinRhea RHEA:47280Inferred only
- 17beta-estradiol is metabolised by CYP3A7ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP3A7ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP3A7ProteinRhea RHEA:47216Inferred only
- 17beta-estradiol is metabolised by CYP3A7ProteinRhea RHEA:47212Inferred only
- 17beta-estradiol is metabolised by CYP4B1ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP4B1ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP4F11ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP4F11ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP4F12ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP4F12ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP4F8ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by CYP4Z1ProteinHuman-GEM MAR02042Inferred only
- 17beta-estradiol is metabolised by CYP4Z1ProteinHuman-GEM MAR02043Inferred only
- 17beta-estradiol is metabolised by SULT1A1ProteinRhea RHEA:52372Inferred only
- 17beta-estradiol is metabolised by SULT1C4ProteinRhea RHEA:52372Inferred only
- 17beta-estradiol is metabolised by SULT1E1ProteinRhea RHEA:52372Inferred only
- 17beta-estradiol is metabolised by UGT1A1ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT1A1ProteinRhea RHEA:52460Inferred only
- 17beta-estradiol is metabolised by UGT1A10ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT1A10ProteinRhea RHEA:52460Inferred only
- 17beta-estradiol is metabolised by UGT1A10ProteinRhea RHEA:52464Inferred only
- 17beta-estradiol is metabolised by UGT1A3ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT1A3ProteinRhea RHEA:52460Inferred only
- 17beta-estradiol is metabolised by UGT1A3ProteinRhea RHEA:52464Inferred only
- 17beta-estradiol is metabolised by UGT1A4ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT1A5ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT1A6ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT1A7ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT1A8ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT1A8ProteinRhea RHEA:52460Inferred only
- 17beta-estradiol is metabolised by UGT1A9ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT2A1ProteinRhea RHEA:52460Inferred only
- 17beta-estradiol is metabolised by UGT2A1ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT2A1ProteinRhea RHEA:52464Inferred only
- 17beta-estradiol is metabolised by UGT2A2ProteinRhea RHEA:52460Inferred only
- 17beta-estradiol is metabolised by UGT2A3ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT2B10ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT2B11ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT2B15ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT2B17ProteinRhea RHEA:52464Inferred only
- 17beta-estradiol is metabolised by UGT2B17ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT2B28ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT2B4ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT2B7ProteinRhea RHEA:52464Inferred only
- 17beta-estradiol is metabolised by UGT2B7ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT3A1ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is metabolised by UGT3A2ProteinHuman-GEM MAR07648Inferred only
- 17beta-estradiol is a substrate of AKR1C1ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of AKR1C2ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of AKR1C3ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of AKR1C4ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B1ProteinHuman-GEM MAR02041Inferred only
- 17beta-estradiol is a substrate of HSD17B1ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B1ProteinHuman-GEM MAR02036Inferred only
- 17beta-estradiol is a substrate of HSD17B10ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B11ProteinHuman-GEM MAR02041Inferred only
- 17beta-estradiol is a substrate of HSD17B11ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B11ProteinHuman-GEM MAR02036Inferred only
- 17beta-estradiol is a substrate of HSD17B12ProteinHuman-GEM MAR02041Inferred only
- 17beta-estradiol is a substrate of HSD17B12ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B12ProteinHuman-GEM MAR02036Inferred only
- 17beta-estradiol is a substrate of HSD17B13ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B2ProteinHuman-GEM MAR02036Inferred only
- 17beta-estradiol is a substrate of HSD17B2ProteinHuman-GEM MAR02041Inferred only
- 17beta-estradiol is a substrate of HSD17B2ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B6ProteinHuman-GEM MAR02041Inferred only
- 17beta-estradiol is a substrate of HSD17B6ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B6ProteinHuman-GEM MAR02036Inferred only
- 17beta-estradiol is a substrate of HSD17B7ProteinHuman-GEM MAR02041Inferred only
- 17beta-estradiol is a substrate of HSD17B7ProteinHuman-GEM MAR02036Inferred only
- 17beta-estradiol is a substrate of HSD17B8ProteinRhea RHEA:24612Inferred only
- 17beta-estradiol is a substrate of HSD17B8ProteinHuman-GEM MAR02036Inferred only
- 17beta-estradiol is a substrate of HSD17B8ProteinHuman-GEM MAR02041Inferred only
Reactions
31 reactions
19-oxotestosterone+NADPH(4-)+dioxygen17beta-estradiol+formic acid+water+NADP(3-)
Catalysed by CYP19A1
Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol
Human-GEM MAR02031CC BY 4.0Reference data
estrone+proton+NADPH(4-)17beta-estradiol+NADP(3-)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageReversibleBalancedEC 1.1.1.62cytosol
Human-GEM MAR02036CC BY 4.0Reference data
estrone+proton+NADPH(4-)17beta-estradiol+NADP(3-)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageReversibleBalancedEC 1.1.1.62endoplasmic reticulum
Human-GEM MAR02041CC BY 4.0Reference data
17beta-estradiol+proton+NADPH(4-)+dioxygen2-hydroxy-17beta-estradiol+water+NADP(3-)
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2C18 or CYP2E1 or CYP2J2 or CYP19A1 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 and 13 more alternatives
Reaction pageLeft to rightBalancedEC 1.14.14.1cytosol
Human-GEM MAR02042CC BY 4.0Reference data
17beta-estradiol+proton+NADPH(4-)+dioxygen2-hydroxy-17beta-estradiol+water+NADP(3-)
Catalysed by CYP3A43 or CYP2D6 or CYP3A5 or CYP2E1 or CYP19A1 or CYP1B1 or CYP2C9 or CYP2C8 or CYP1A1 or CYP1A2 or CYP4B1 or CYP2U1 and 13 more alternatives
Reaction pageLeft to rightBalancedEC 1.14.14.1endoplasmic reticulum
Human-GEM MAR02043CC BY 4.0Reference data
17beta-estradiol+proton+NADPH(4-)+dioxygen4-hydroxy-17beta-estradiol+water+NADP(3-)
Catalysed by CYP3A4
Reaction pageLeft to rightBalancedEC 1.14.14.55cytosol
Human-GEM MAR02046CC BY 4.0Reference data
17beta-estradiol+proton+NADPH(4-)+dioxygen4-hydroxy-17beta-estradiol+water+NADP(3-)
Catalysed by CYP3A4
Reaction pageLeft to rightBalancedEC 1.14.14.55endoplasmic reticulum
Human-GEM MAR02047CC BY 4.0Reference data
17beta-estradiol+UDP-alpha-D-glucuronate17beta-estradiol 3-O-(beta-D-glucuronate)+UDP
Catalysed by UGT2B10 or UGT2A3 or UGT2B28 or UGT3A1 or UGT2B4 or UGT1A6 or UGT3A2 or UGT2B7 or UGT2A1 or UGT2B15 or UGT2B17 or UGT2B11 and 8 more alternatives
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR07648CC BY 4.0Reference data
NADPH(4-)+2dioxygen+testosterone17beta-estradiol+formic acid+2water+NADP(3-)
Catalysed by CYP19A1
Reaction pageLeft to rightBalancedEC 1.14.14.14endoplasmic reticulum
Human-GEM MAR07941CC BY 4.0Reference data
estrone+proton+NADH(2-)17beta-estradiol+NAD(+)
Catalysed by HSD17B6 or HSD17B2 or HSD17B1 or HSD17B7 or HSD17B12 or HSD17B11 or HSD17B8
Reaction pageLeft to rightBalancedEC 1.1.1.62, 1.1.1.64endoplasmic reticulum
Human-GEM MAR07968CC BY 4.0Reference data
17beta-estradiol17beta-estradiol
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR07969CC BY 4.0Reference data
17beta-estradiol17beta-estradiol
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR08870CC BY 4.0Reference data
Other names
17 names
Resolves to: 17beta-estradiol
- Also called
- (17beta)-estra-1,3,5(10)-triene-3,17-diol(17β)-estra-1,3,5(10)-triene-3,17-diol17b-Oestradiol17beta oestradiol17beta-estra-1,3,5(10)-triene-3,17-diol17beta-oestradiol17β-estra-1,3,5(10)-triene-3,17-diol17β-estradiol17β-oestradiol3,17b-Dihydroxyestra-1,3,5(10)-trienebeta-Estradiolcis-estradiolESTRADIOLEstradiol-17betaST 18:3;O2
- Systematic name
- estra-1,3,5(10)-triene-3,17beta-diolestra-1,3,5(10)-triene-3,17β-diol