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Proteins/UNIPROT:P07101
Catalyzes the conversion of L-tyrosine to L-dihydroxyphenylalanine (L-Dopa), the rate-limiting step in the biosynthesis of catecholamines, dopamine, noradrenaline, and adrenaline. Uses tetrahydrobiopterin and molecular oxygen to convert tyrosine to L-Dopa (PubMed:15287903, PubMed:1680128, PubMed:17391063, PubMed:24753243, PubMed:34922205, PubMed:8528210, Ref.18). In addition to tyrosine, is able to catalyze the hydroxylation of phenylalanine and tryptophan with lower specificity (By similarity). Positively regulates the regression of retinal hyaloid vessels during postnatal development (By similarity)..
[Isoform 5]: Lacks catalytic activity..
[Isoform 6]: Lacks catalytic activity..
Function from UniProtKB (P07101), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
76 statements
76 statements · 8 reference databases · Subject: TH · Sources: gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
3 reactions
dioxygen+5,6,7,8-tetrahydrobiopterin+CHEBI:17895MAM01698c+water+CHEBI:15765
Catalysed by TH
Reaction pageLeft to rightBalancedEC 1.14.16.2cytosol
Human-GEM MAR06728CC BY 4.0Reference data
dioxygen+5,6,7,8-tetrahydrobiopterin+CHEBI:178954a-hydroxytetrahydrobiopterin+CHEBI:15765
Catalysed by
2 names
Resolves to: TH
Reaction pageLeft to rightBalancedEC 1.14.16.2cytosol
Human-GEM MAR08537CC BY 4.0Reference data
(6R)-L-erythro-5,6,7,8-tetrahydrobiopterin+L-tyrosine+dioxygen(4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin+L-dopa
Catalysed by TH
Reaction pageLeft to rightBalanced
Rhea RHEA:18201CC BY 4.0Reference data