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A reference for what the literature reports. Not medical advice.

© 2026 CatalystPrivacy TermsReference data under the licences listed on the attribution page.

Proteins/UNIPROT:P26439

HSD3B2

Protein·UNIPROT:P264393 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2

Open in the graph

3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids..

Function from UniProtKB (P26439), read 2026-09-23. CC BY 4.0.

Curated compounds routed: 0

What the reference databases state

Inferred

Inferred — not reported by a source. Evidence key

GenCC submitters' classifications

1 row

congenital adrenal hyperplasia due to 3-beta-hydroxysteroid dehydrogenase deficiency has a germline basis in HSD3B2DiseaseGenCC HGNC:5218|MONDO:0008727Inferred only

Statements

52 statements

52 statements · 6 reference databases · Subject: HSD3B2 · Sources: Bgee, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways

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HSD3B2 is expressed in adrenal cortexAnatomyBgee ENSG00000203859Inferred only
HSD3B2 is expressed in adrenal glandAnatomyBgee ENSG00000203859Inferred only
HSD3B2 is expressed in adrenal glandAnatomyHuman Protein Atlas ENSG00000203859Inferred only
HSD3B2 is expressed in left adrenal glandAnatomyBgee ENSG00000203859Inferred only
HSD3B2 is expressed in left adrenal gland cortexAnatomyBgee ENSG00000203859Inferred only
HSD3B2 is expressed in right adrenal glandAnatomyBgee ENSG00000203859Inferred only
HSD3B2 is expressed in right adrenal gland cortexAnatomyBgee ENSG00000203859Inferred only
HSD3B2 is expressed in testisAnatomyHuman Protein Atlas ENSG00000203859Inferred only
HSD3B2 participates in Alternative pathway of fetal androgen synthesisPathwayWikiPathways WP4524Inferred only
HSD3B2 participates in Androgen biosynthesisPathwayWikiPathways WP5393Inferred only
HSD3B2 participates in Androgen biosynthesisPathwayReactome R-HSA-193048Inferred only
HSD3B2 participates in Androgen receptor network in prostate cancerPathwayWikiPathways WP2263Inferred only

Show the remaining 40

HSD3B2 participates in Cholesterol synthesis disordersPathwayWikiPathways WP5193Inferred only
HSD3B2 participates in Classical pathway of steroidogenesis with glucocorticoid and mineralocorticoid metabolismPathwayWikiPathways WP4523Inferred only
HSD3B2 participates in Corticotropin releasing hormone signalingPathwayWikiPathways WP2355Inferred only
HSD3B2 participates in Glucocorticoid biosynthesisPathwayReactome R-HSA-194002Inferred only
HSD3B2 participates in Male steroid hormones in cardiomyocyte energy metabolismPathwayWikiPathways WP5320Inferred only
HSD3B2 participates in MetabolismPathwayReactome R-HSA-1430728Inferred only
HSD3B2 participates in Metabolism of lipidsPathwayReactome R-HSA-556833Inferred only
HSD3B2 participates in Metabolism of steroid hormonesPathwayReactome R-HSA-196071Inferred only
HSD3B2 participates in Metabolism of steroidsPathwayReactome R-HSA-8957322Inferred only
HSD3B2 participates in Mineralocorticoid biosynthesisPathwayReactome R-HSA-193993Inferred only
HSD3B2 participates in Peroxiredoxin 2 induced ovarian failurePathwayWikiPathways WP4873Inferred only
HSD3B2 participates in Renin angiotensin aldosterone system RAAS PathwayWikiPathways WP4756Inferred only
HSD3B2 participates in Steroid biosynthesisPathwayWikiPathways WP496Inferred only
HSD3B2 participates in Steroid hormone precursor biosynthesisPathwayWikiPathways WP5277Inferred only
17alpha-hydroxypregnenolone is a substrate of HSD3B2CompoundHuman-GEM MAR07939Inferred only
17alpha-hydroxypregnenolone is a substrate of HSD3B2CompoundHuman-GEM MAR01982Inferred only
17alpha-hydroxypregnenolone is a substrate of HSD3B2CompoundHuman-GEM MAR07973Inferred only
17alpha,21-dihydroxypregnenolone is a substrate of HSD3B2CompoundHuman-GEM MAR01949Inferred only
17beta-hydroxy-5alpha-androstan-3-one is a substrate of HSD3B2CompoundHuman-GEM MAR03400Inferred only
17beta-hydroxy-5alpha-androstan-3-one is a substrate of HSD3B2CompoundHuman-GEM MAR02024Inferred only
17beta-hydroxy-5alpha-androstan-3-one is a substrate of HSD3B2CompoundHuman-GEM MAR02022Inferred only
3beta-hydroxyandrost-5-en-17-one is a substrate of HSD3B2CompoundHuman-GEM MAR01967Inferred only
3beta-hydroxyandrost-5-en-17-one is a substrate of HSD3B2CompoundHuman-GEM MAR07954Inferred only
3beta-hydroxyandrost-5-en-17-one is a substrate of HSD3B2CompoundHuman-GEM MAR01968Inferred only
3beta-hydroxyandrost-5-en-17-one is a substrate of HSD3B2CompoundRhea RHEA:43932Inferred only
3beta,16alpha-dihydroxy-androst-5-en-17-one is a substrate of HSD3B2CompoundHuman-GEM MAR07972Inferred only
3beta,16alpha-dihydroxy-androst-5-en-17-one is a substrate of HSD3B2CompoundHuman-GEM MAR07971Inferred only
7alpha-hydroxycholest-4-en-3-one is a substrate of HSD3B2CompoundHuman-GEM MAR02881Inferred only
androst-5-en-3beta,17beta-diol is a substrate of HSD3B2CompoundHuman-GEM MAR03400Inferred only
androst-5-en-3beta,17beta-diol is a substrate of HSD3B2CompoundHuman-GEM MAR02024Inferred only
androst-5-en-3beta,17beta-diol is a substrate of HSD3B2CompoundHuman-GEM MAR02022Inferred only
androst-5-ene-3,17-dione is a substrate of HSD3B2CompoundRhea RHEA:43936Inferred only
androst-5-ene-3,17-dione is a substrate of HSD3B2CompoundHuman-GEM MAR01970Inferred only
androst-5-ene-3,17-dione is a substrate of HSD3B2CompoundHuman-GEM MAR01971Inferred only
pregn-5-ene-3,20-dione is a substrate of HSD3B2CompoundRhea RHEA:43928Inferred only
pregn-5-ene-3,20-dione is a substrate of HSD3B2CompoundHuman-GEM MAR01980Inferred only
pregnenolone is a substrate of HSD3B2CompoundRhea RHEA:43924Inferred only
pregnenolone is a substrate of HSD3B2CompoundHuman-GEM MAR07930Inferred only
pregnenolone is a substrate of HSD3B2CompoundHuman-GEM MAR01979Inferred only
pregnenolone is a substrate of HSD3B2CompoundHuman-GEM MAR07931Inferred only

Reactions

29 reactions

MAM00592r+NAD(+)7alpha-hydroxycholest-4-en-3-one+proton+NADH(2-)
Catalysed by HSD3B1 or HSD3B2
Reaction pageLeft to rightBalancedEC 1.1.1.145, 5.3.3.1endoplasmic reticulum
Human-GEM MAR01783CC BY 4.0Reference data
MAM00605c+NAD(+)21-hydroxyprogesterone+proton+NADH(2-)
Catalysed by HSD3B1

Other names

9 names

Resolves to: HSD3B2

Also called: ]3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II3-beta-HSD adrenal and gonadal type3-beta-HSD II3-beta-hydroxy-5-ene steroid dehydrogenase5Delta-5-3-ketosteroid isomeraseHSDB3BProgesterone reductase

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Reaction pageLeft to rightBalancedEC 1.1.1.145, 5.3.3.1cytosol

Human-GEM MAR01941CC BY 4.0Reference data

17alpha,21-dihydroxypregnenolone+NAD(+)11-deoxycortisol+proton+NADH(2-)

Catalysed by HSD3B1 or HSD3B2

Reaction pageLeft to rightBalancedEC 1.1.1.145, 5.3.3.1cytosol

Human-GEM MAR01949CC BY 4.0Reference data

MAM00283c+NAD(+)cortisol+proton+NADH(2-)

Catalysed by HSD3B1 or HSD3B2

Reaction pageLeft to rightBalancedEC 1.1.1.145, 5.3.3.1cytosol

Human-GEM MAR01951CC BY 4.0Reference data

3beta-hydroxyandrost-5-en-17-one+NAD(+)androst-5-ene-3,17-dione+proton+NADH(2-)

Catalysed by HSD3B1 or HSD3B2

Reaction pageLeft to rightBalancedEC 1.1.1.145cytosol

Human-GEM MAR01967CC BY 4.0Reference data

3beta-hydroxyandrost-5-en-17-one+NAD(+)androst-5-ene-3,17-dione+proton+NADH(2-)

Catalysed by HSD3B1 or HSD3B2

Reaction pageLeft to rightBalancedEC 1.1.1.145endoplasmic reticulum

Human-GEM MAR01968CC BY 4.0Reference data

androst-5-ene-3,17-dione+proton+NAD(+)androst-4-ene-3,17-dione+NADH(2-)

Catalysed by HSD3B1 or HSD3B2

Reaction pageLeft to rightUnbalancedEC 5.3.3.1cytosol

Human-GEM MAR01970CC BY 4.0Reference data

androst-5-ene-3,17-dione+proton+NAD(+)androst-4-ene-3,17-dione+NADH(2-)

Catalysed by HSD3B1 or HSD3B2

Reaction pageLeft to rightUnbalancedEC 5.3.3.1endoplasmic reticulum

Human-GEM MAR01971CC BY 4.0Reference data

NAD(+)+pregnenoloneproton+NADH(2-)+pregn-5-ene-3,20-dione

Catalysed by HSD3B1 or HSD3B2

Reaction pageLeft to rightBalancedEC 1.1.1.145cytosol

Human-GEM MAR01979CC BY 4.0Reference data

pregn-5-ene-3,20-dioneprogesterone

Catalysed by HSD3B1 or HSD3B2

Reaction pageLeft to rightBalancedEC 5.3.3.1cytosol

Human-GEM MAR01980CC BY 4.0Reference data

17alpha-hydroxypregnenolone+NAD(+)proton+NADH(2-)+MAM02761c

Catalysed by HSD3B1 or HSD3B2

Reaction pageLeft to rightBalancedEC 1.1.1.145cytosol

Human-GEM MAR01982CC BY 4.0Reference data

MAM02761c17alpha-hydroxyprogesterone

Catalysed by HSD3B1 or HSD3B2

Reaction pageLeft to rightBalancedEC 5.3.3.1cytosol

Human-GEM MAR01983CC BY 4.0Reference data

Show the remaining 17