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Proteins/UNIPROT:P11678
Heme-containing oxidoreductase that catalyzes the oxidation of small anions, such as nitrite, halides (e.g bromide and chloride (at pH 6.5)) and pseudohalides (e.g thiocyanate) by using hydrogen peroxide to generate the corresponding reactive species hypobromite, hypochlorite, hypothiocyanous acid, and nitrogen dioxide. Also oxidizes thiocyanate (SCN(-)) to cyanate (OCN(-)). Functionally involved in inflammatory responses and exhibits antimicrobial activity. Can also oxidize amino acid residues on proteins and generate bromination, nitration and carbamoylation post-translational modifications, respectively. Mediates the nitration of tyrosine (3-nitrotyrosine) which is only observed in secondary granule proteins in mature resting eosinophils in the presence of the cosubstrates, hydrogen peroxide and nitrite. Mediates oxidation of tyrosine residues on proteins in eosinophils to form brominating species, 3-bromotyrosine and 3, 5-dibromotyrosine in the presence of hydrogen peroxide and bromide (By similarity). Promotes protein carbamoylation at sites of inflammation during asthma by using thiocyanate and hydrogen peroxide to form cyanate which carbamoylates lysine residues to form homocitrulline..
Function from UniProtKB (P11678), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
39 statements
39 statements · 6 reference databases · Subject: EPX · Sources: Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt
26 reactions
2-hydroxyestrone+proton+hydrogen peroxideMAM01792c+2water
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol
Human-GEM MAR02061CC BY 4.0Reference data
8 names
Resolves to: EPX
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2lysosome
Human-GEM MAR02062CC BY 4.0Reference data
2-hydroxyestrone+proton+hydrogen peroxideMAM01792r+2water
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2endoplasmic reticulum
Human-GEM MAR02063CC BY 4.0Reference data
MAM01000c+proton+hydrogen peroxideMAM01794c+2water
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol
Human-GEM MAR02076CC BY 4.0Reference data
MAM01000l+proton+hydrogen peroxideMAM01794l+2water
Catalysed by MPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2lysosome
Human-GEM MAR02077CC BY 4.0Reference data
MAM01000r+proton+hydrogen peroxideMAM01794r+2water
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2endoplasmic reticulum
Human-GEM MAR02078CC BY 4.0Reference data
MAM00413c+2water4-hydroxy-17beta-estradiol+hydrogen peroxide
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleBalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol
Human-GEM MAR02088CC BY 4.0Reference data
MAM00413l+2water4-hydroxy-17beta-estradiol+hydrogen peroxide
Catalysed by MPO or PRDX6 or EPX or LPO
Reaction pageReversibleBalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2lysosome
Human-GEM MAR02089CC BY 4.0Reference data
MAM00411c+2water2-hydroxy-17beta-estradiol+proton+hydrogen peroxide
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2cytosol
Human-GEM MAR02099CC BY 4.0Reference data
MAM00411l+2water2-hydroxy-17beta-estradiol+proton+hydrogen peroxide
Catalysed by MPO or TPO or PRDX6 or EPX or LPO
Reaction pageReversibleUnbalancedEC 1.11.1.7, 1.11.1.8, 1.11.2.2lysosome
Human-GEM MAR02100CC BY 4.0Reference data
hydrogen peroxide+methanolformaldehyde+2water
Catalysed by PRDX6 or EPX or CAT or PXDN or LPO
Reaction pageLeft to rightBalancedEC 1.11.1.6, 1.11.1.7cytosol
Human-GEM MAR04201CC BY 4.0Reference data
proton+hydrogen peroxide+thiocyanatewater+hypothiocyanous acid
Reaction pageReversibleBalancedEC 1.11.1.7, 1.2.4.4, 1.8.1.4cytosol
Human-GEM MAR06523CC BY 4.0Reference data