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Proteins/UNIPROT:P53007
Mitochondrial electroneutral antiporter that exports citrate from the mitochondria into the cytosol in exchange for malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis-aconitate and to a lesser extent trans-aconitate, maleate and succinate. Substrate exchange across the membrane occurs consecutively with one substrate being transported first, then dissociating from the substrate binding site before the second substrate binds for transport in the opposite direction. In the cytoplasm, citrate plays important roles in fatty acid and sterol synthesis, regulation of glycolysis, protein acetylation, and other physiopathological processes..
Function from UniProtKB (P53007), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
3 rows
234 statements
234 statements · 7 reference databases · Subject: SLC25A1 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
35 reactions
citric acid+(S)-malatecitric acid+(S)-malate
Transported by SLC25A1
Reaction pageReversibleBalancedEC 4.2.1.56cytosol, mitochondrial matrix
Human-GEM MAR00125CC BY 4.0Reference data
isocitric acid+(S)-malateisocitric acid+(S)-malate
Transported by SLC25A1
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
7 names
Resolves to: SLC25A1
citric acid+succinate(2-)citric acid+succinate(2-)
Transported by SLC25A1
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR02220CC BY 4.0Reference data
2-oxoglutarate(2-)+isocitric acid2-oxoglutarate(2-)+isocitric acid
Transported by SLC25A1
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR02303CC BY 4.0Reference data
2-oxoglutarate(2-)+citric acid2-oxoglutarate(2-)+citric acid
Transported by SLC25A1
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR02405CC BY 4.0Reference data
citric acid+oxalic acidcitric acid+oxalic acid
Transported by SLC25A1
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR02406CC BY 4.0Reference data
isocitric acid+succinate(2-)isocitric acid+succinate(2-)
Transported by SLC25A1
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR02413CC BY 4.0Reference data
isocitric acid+oxalic acidisocitric acid+oxalic acid
Transported by SLC25A1
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR02414CC BY 4.0Reference data
2-oxoglutarate(2-)+cis-aconitic acid2-oxoglutarate(2-)+cis-aconitic acid
Transported by SLC25A1
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR02416CC BY 4.0Reference data
cis-aconitic acid+succinate(2-)cis-aconitic acid+succinate(2-)
Transported by SLC25A1
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR02418CC BY 4.0Reference data
cis-aconitic acid+(S)-malatecis-aconitic acid+(S)-malate
Transported by SLC25A1
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR02420CC BY 4.0Reference data
cis-aconitic acid+oxalic acidcis-aconitic acid+oxalic acid
Transported by SLC25A1
Reaction pageReversibleBalancedmitochondrial matrix, cytosol
Human-GEM MAR02422CC BY 4.0Reference data