Loading the page.
Proteins/UNIPROT:Q8IVM8
Sodium-independent organic anion transporter, exhibits high specificity for sulfated conjugates of xenobiotics and steroid hormones such as estrone 3-sulfate (E1S) and dehydroepiandrosterone sulfate (DHEAS). Can transport the statin pravastatin and may contribute to its disposition into the hepatocytes when the function of OATPs is compromised. It is specifically activated by 3 to 5 carbons-containing short-chain fatty acids/SCFAs, including propionate (propanoate), butyrate (butanoate) and valerate (pentanoate). May operate the exchange of sulfated organic components against short-chain fatty acids/SCFAs, in particular butanoate, at the sinusoidal membrane of hepatocytes..
Function from UniProtKB (Q8IVM8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
19 statements
19 statements · 3 reference databases · Subject: SLC22A9 · Sources: Hetionet, Human-GEM, Rhea
10 reactions
MAM00107c+(S)-carnitineMAM00107m+(S)-carnitine
Transported by SLC22A9 or SLC22A1 or SLC25A20 or SLC22A4
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR02715CC BY 4.0Reference data
(S)-carnitine+MAM02388m(S)-carnitine+MAM02388c
5 names
Resolves to: SLC22A9
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR02744CC BY 4.0Reference data
MAM00022c+(S)-carnitineMAM00022m+(S)-carnitine
Transported by SLC22A9 or SLC22A1 or SLC25A20 or SLC22A4
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR02772CC BY 4.0Reference data
MAM00263c+(S)-carnitineMAM00263m+(S)-carnitine
Transported by SLC22A9 or SLC22A1 or SLC25A20 or SLC22A4
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR02775CC BY 4.0Reference data
butanoate+estrone 3-sulfatebutanoate+estrone 3-sulfate
Transported by SLC22A9
Reaction pageDirection not assertedBalanced
Rhea RHEA:72051CC BY 4.0Reference data
propanoate+estrone 3-sulfatepropanoate+estrone 3-sulfate
Transported by SLC22A9
Reaction pageDirection not assertedBalanced
Rhea RHEA:72555CC BY 4.0Reference data
pentanoate+estrone 3-sulfatepentanoate+estrone 3-sulfate
Transported by SLC22A9
Reaction pageDirection not assertedBalanced
Rhea RHEA:72559CC BY 4.0Reference data
dehydroepiandrosterone 3-sulfate+butanoatedehydroepiandrosterone 3-sulfate+butanoate
Transported by SLC22A9
Reaction pageDirection not assertedBalanced
Rhea RHEA:72563CC BY 4.0Reference data
propanoate+dehydroepiandrosterone 3-sulfatepropanoate+dehydroepiandrosterone 3-sulfate
Transported by SLC22A9
Reaction pageDirection not assertedBalanced
Rhea RHEA:72567CC BY 4.0Reference data
pentanoate+dehydroepiandrosterone 3-sulfatepentanoate+dehydroepiandrosterone 3-sulfate
Transported by SLC22A9
Reaction pageDirection not assertedBalanced
Rhea RHEA:72571CC BY 4.0Reference data