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Proteins/UNIPROT:O75452
Oxidoreductase with a preference for NAD. Oxidizes all-trans-retinol, 9-cis-retinol, 11-cis-retinol and 13-cis-retinol to the corresponding aldehydes. Has higher activity towards CRBP-bound retinol than with free retinol. Also oxidizes 3-alpha-hydroxysteroids. Oxidizes androstanediol and androsterone to dihydrotestosterone and androstanedione. Can also catalyze the reverse reaction..
Function from UniProtKB (O75452), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
25 statements
25 statements · 5 reference databases · Subject: RDH16 · Sources: Bgee, Human Protein Atlas, Human-GEM, Reactome, Rhea
10 reactions
11-cis-retinal+proton+NADH(2-)11-cis-retinol+NAD(+)
Catalysed by HSD17B6 or RDH5 or RDH16 or RLBP1 or DHRS4 or DHRS4L2 or RBP3
Reaction pageReversibleBalancedEC 1.1.1.105cytosol
Human-GEM MAR06638CC BY 4.0Reference data
8 names
Resolves to: RDH16
Reaction pageReversibleBalancedEC 1.1.1.105cytosol
Human-GEM MAR06644CC BY 4.0Reference data
11-cis-retinal+proton+NADPH(4-)11-cis-retinol+NADP(3-)
Catalysed by HSD17B6 or RDH5 or RDH16 or RLBP1 or DHRS4 or DHRS4L2 or RBP3
Reaction pageReversibleBalancedEC 1.1.1.105cytosol
Human-GEM MAR08709CC BY 4.0Reference data
androsterone+NAD(1-)5alpha-androstan-3,17-dione+NADH(2-)+hydron
Catalysed by HSD17B6 or RDH16 or RDH5 or DHRS9
Reaction pageReversibleBalanced
Rhea RHEA:20381CC BY 4.0Reference data
all-trans-retinol+NAD(1-)all-trans-retinal+NADH(2-)+hydron
Catalysed by DHRS7C or HSD17B6 or RDH16 or ADH1B or ADH4 or ADH7 or HSD17B13 or DHRS9
Reaction pageLeft to rightBalanced
Rhea RHEA:21284CC BY 4.0Reference data
5alpha-androstane-3alpha,17beta-diol+NAD(1-)17beta-hydroxy-5alpha-androstan-3-one+NADH(2-)+hydron
Catalysed by HSD17B6 or RDH16 or AKR1C4 or AKR1C3 or AKR1C2 or AKR1C1 or RDH5 or HSD17B10 or DHRS9
Reaction pageRight to leftBalanced
Rhea RHEA:42004CC BY 4.0Reference data
9-cis-retinol+NAD(1-)9-cis-retinal+NADH(2-)+hydron
Catalysed by RDH16 or ADH4 or ADH7 or RDH5
Reaction pageLeft to rightBalanced
Rhea RHEA:42052CC BY 4.0Reference data
13-cis-retinol+NAD(1-)13-cis-retinal+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:42056CC BY 4.0Reference data
11-cis-retinol+NAD(1-)11-cis-retinal+NADH(2-)+hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:42060CC BY 4.0Reference data
all-trans-retinol--[retinol-binding protein]+NAD(1-)all-trans-retinal--[retinol-binding protein]+NADH(2-)+hydron
Catalysed by HSD17B6 or RDH16 or SDR16C5
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:48488CC BY 4.0Reference data