Compound
thioredoxin dithiol
Hydrogen-donating proteins that participates in a variety of biochemical reactions including ribonucleotide reduction and reduction of peroxiredoxins. Thioredoxin is oxidized from a dithiol to a disulfide when acting as a reducing cofactor. The disulfide form is then reduced by nadph in a reaction catalyzed by thioredoxin reductase.
What it touches on the way
Mechanistic reach
7 entities
7 entities reached.
0 reported hops7 assembled from the scaffold
- TXNProteinUNIPROT:P10599substrate ofInferred only160 paths16 endpoints
- RRM1ProteinUNIPROT:P23921substrate ofInferred only85 paths9 endpoints
- RRM2ProteinUNIPROT:P31350substrate ofInferred only80 paths8 endpoints
- TXN2ProteinUNIPROT:Q99757substrate ofInferred only40 paths4 endpoints
- SULT1A3ProteinUNIPROT:P0DMM9metabolized byInferred only15 paths15 endpoints
- RRM2BProteinUNIPROT:Q7LG56substrate ofInferred only10 paths1 endpoint
- MSRAProteinUNIPROT:Q9UJ68substrate ofInferred only5 paths5 endpoints
What the reference databases state
Statements
55 statements
55 statements · 1 reference database · Subject: thioredoxin dithiol · Sources: Human-GEM
- thioredoxin disulfide is converted to thioredoxin dithiolCompoundHuman-GEM MAR03931Inferred only
- thioredoxin disulfide is converted to thioredoxin dithiolCompoundHuman-GEM MAR08482Inferred only
- thioredoxin disulfide is converted to thioredoxin dithiolCompoundHuman-GEM MAR05417Inferred only
- thioredoxin dithiol is metabolised by SULT1A3ProteinHuman-GEM MAR05381Inferred only
- thioredoxin dithiol is a substrate of MSRAProteinHuman-GEM MAR09544Inferred only
- thioredoxin dithiol is a substrate of RRM1ProteinHuman-GEM MAR04617Inferred only
- thioredoxin dithiol is a substrate of RRM1ProteinHuman-GEM MAR04619Inferred only
- thioredoxin dithiol is a substrate of RRM1ProteinHuman-GEM MAR04618Inferred only
- thioredoxin dithiol is a substrate of RRM1ProteinHuman-GEM MAR06622Inferred only
- thioredoxin dithiol is a substrate of RRM1ProteinHuman-GEM MAR04612Inferred only
- thioredoxin dithiol is a substrate of RRM1ProteinHuman-GEM MAR04611Inferred only
- thioredoxin dithiol is a substrate of RRM1ProteinHuman-GEM MAR06621Inferred only
Show the remaining 43
- thioredoxin dithiol is a substrate of RRM1ProteinHuman-GEM MAR04614Inferred only
- thioredoxin dithiol is a substrate of RRM1ProteinHuman-GEM MAR04621Inferred only
- thioredoxin dithiol is a substrate of RRM1ProteinHuman-GEM MAR04615Inferred only
- thioredoxin dithiol is a substrate of RRM2ProteinHuman-GEM MAR06622Inferred only
- thioredoxin dithiol is a substrate of RRM2ProteinHuman-GEM MAR04615Inferred only
- thioredoxin dithiol is a substrate of RRM2ProteinHuman-GEM MAR04618Inferred only
- thioredoxin dithiol is a substrate of RRM2ProteinHuman-GEM MAR04617Inferred only
- thioredoxin dithiol is a substrate of RRM2ProteinHuman-GEM MAR04614Inferred only
- thioredoxin dithiol is a substrate of RRM2ProteinHuman-GEM MAR04621Inferred only
- thioredoxin dithiol is a substrate of RRM2ProteinHuman-GEM MAR04611Inferred only
- thioredoxin dithiol is a substrate of RRM2ProteinHuman-GEM MAR04612Inferred only
- thioredoxin dithiol is a substrate of RRM2ProteinHuman-GEM MAR06621Inferred only
- thioredoxin dithiol is a substrate of RRM2ProteinHuman-GEM MAR04619Inferred only
- thioredoxin dithiol is a substrate of RRM2BProteinHuman-GEM MAR04611Inferred only
- thioredoxin dithiol is a substrate of RRM2BProteinHuman-GEM MAR04612Inferred only
- thioredoxin dithiol is a substrate of RRM2BProteinHuman-GEM MAR04614Inferred only
- thioredoxin dithiol is a substrate of RRM2BProteinHuman-GEM MAR04615Inferred only
- thioredoxin dithiol is a substrate of RRM2BProteinHuman-GEM MAR04617Inferred only
- thioredoxin dithiol is a substrate of RRM2BProteinHuman-GEM MAR04618Inferred only
- thioredoxin dithiol is a substrate of RRM2BProteinHuman-GEM MAR04619Inferred only
- thioredoxin dithiol is a substrate of RRM2BProteinHuman-GEM MAR04621Inferred only
- thioredoxin dithiol is a substrate of RRM2BProteinHuman-GEM MAR06621Inferred only
- thioredoxin dithiol is a substrate of RRM2BProteinHuman-GEM MAR06622Inferred only
- thioredoxin dithiol is a substrate of TXNProteinHuman-GEM MAR06622Inferred only
- thioredoxin dithiol is a substrate of TXNProteinHuman-GEM MAR04618Inferred only
- thioredoxin dithiol is a substrate of TXNProteinHuman-GEM MAR04615Inferred only
- thioredoxin dithiol is a substrate of TXNProteinHuman-GEM MAR04612Inferred only
- thioredoxin dithiol is a substrate of TXNProteinHuman-GEM MAR06621Inferred only
- thioredoxin dithiol is a substrate of TXNProteinHuman-GEM MAR04611Inferred only
- thioredoxin dithiol is a substrate of TXNProteinHuman-GEM MAR04619Inferred only
- thioredoxin dithiol is a substrate of TXNProteinHuman-GEM MAR04614Inferred only
- thioredoxin dithiol is a substrate of TXNProteinHuman-GEM MAR04621Inferred only
- thioredoxin dithiol is a substrate of TXNProteinHuman-GEM MAR04617Inferred only
- thioredoxin dithiol is a substrate of TXN2ProteinHuman-GEM MAR04611Inferred only
- thioredoxin dithiol is a substrate of TXN2ProteinHuman-GEM MAR04617Inferred only
- thioredoxin dithiol is a substrate of TXN2ProteinHuman-GEM MAR04621Inferred only
- thioredoxin dithiol is a substrate of TXN2ProteinHuman-GEM MAR04615Inferred only
- thioredoxin dithiol is a substrate of TXN2ProteinHuman-GEM MAR06621Inferred only
- thioredoxin dithiol is a substrate of TXN2ProteinHuman-GEM MAR04614Inferred only
- thioredoxin dithiol is a substrate of TXN2ProteinHuman-GEM MAR06622Inferred only
- thioredoxin dithiol is a substrate of TXN2ProteinHuman-GEM MAR04612Inferred only
- thioredoxin dithiol is a substrate of TXN2ProteinHuman-GEM MAR04618Inferred only
- thioredoxin dithiol is a substrate of TXN2ProteinHuman-GEM MAR04619Inferred only
Reactions
27 reactions
CHEBI:16174+water+thioredoxin disulfideADP+thioredoxin dithiol
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1GO:0005759
Human-GEM MAR02352CC BY 4.0Reference data
CHEBI:28862+water+thioredoxin disulfideGDP+thioredoxin dithiol
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1GO:0005759
Human-GEM MAR02357CC BY 4.0Reference data
thioredoxin dithiolthioredoxin dithiol
Reaction pageLeft to rightBalancedEC 3.4.19.9GO:0005829, GO:0005759
Human-GEM MAR02360CC BY 4.0Reference data
proton+NADPH(4-)+thioredoxin disulfideNADP(3-)+thioredoxin dithiol
Reaction pageLeft to rightBalancedEC 1.8.1.9GO:0005829
Human-GEM MAR03931CC BY 4.0Reference data
ATP+thioredoxin dithiolCHEBI:16284+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1GO:0005829
Human-GEM MAR04611CC BY 4.0Reference data
ADP+thioredoxin dithiolCHEBI:16174+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1GO:0005829
Human-GEM MAR04612CC BY 4.0Reference data
GTP+thioredoxin dithiolCHEBI:16497+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1GO:0005829
Human-GEM MAR04614CC BY 4.0Reference data
GDP+thioredoxin dithiolCHEBI:28862+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1GO:0005829
Human-GEM MAR04615CC BY 4.0Reference data
CHEBI:17677+thioredoxin dithioldCTP+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1GO:0005829
Human-GEM MAR04617CC BY 4.0Reference data
thioredoxin dithiol+UTPdUTP+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1GO:0005829
Human-GEM MAR04618CC BY 4.0Reference data
CHEBI:17239+thioredoxin dithioldCDP+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1GO:0005829
Human-GEM MAR04619CC BY 4.0Reference data
thioredoxin dithiol+UDPMAM01754c+water+thioredoxin disulfide
Catalysed by RRM1 & RRM2 & RRM2B & TXN2 or TXN & RRM1 & RRM2 & RRM2B
Reaction pageLeft to rightBalancedEC 1.17.4.1GO:0005829
Human-GEM MAR04621CC BY 4.0Reference data
Other names
2 names
Resolves to: thioredoxin dithiol
- Also called
- Reduced thioredoxinThioredoxin