5alpha-androstan-3,17-dione

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

67 compounds within 3 steps: 4 in 1, 16 in 2, 47 in 3

One step

androsteroneReach from here →
1. Androsterone:NAD+ oxidoreductase
Catalysed by AKR1C4, AKR1C3, AKR1C2, AKR1C1cytosolOne of 6 routes
17beta-hydroxy-5alpha-androstan-3-oneReach from here →
1. 17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)
Catalysed by AKR1B15, HSD17B3, AKR1C1
androst-4-ene-3,17-dioneReach from here →
1. 5alpha-androstane-3,17-dione:NADP+ delta4-oxidoreductase
Catalysed by AKR1D1cytosolOne of 3 routes
3beta-hydroxy-5alpha-androstan-17-oneReach from here →
1. 3beta-hydroxy-5alpha-androstan-17-one + NAD(+) = 5alpha-androstan-3,17-dione + NADH + H(+)
Catalysed by HSD17B6One of 2 routes

Two steps

androsterone 3alpha-sulfateReach from here →
1. Androsterone:NAD+ oxidoreductase
2. steroid sulfatase (androsterone sulfate)
Catalysed by AKR1C4, AKR1C3, AKR1C2, AKR1C1 and 1 morecytosolOne of 4 routes
5alpha-dihydrotestosterone 17-O-(beta-D-glucuronate)Reach from here →
1. 17beta-hydroxy-5alpha-androstan-3-one + NADP(+) = 5alpha-androstan-3,17-dione + NADPH + H(+)
2. glucuronosyltransferase (5-alpha-dihydrotestosterone)
Catalysed by AKR1B15, HSD17B3, AKR1C1 and 4 more

Three steps

2-hydroxybutyric acidReach from here →
Catalysed by AKR1D1, CYP19A1, SLC16A4, SLC16A5 and 2 morecytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes
2-hydroxyestroneReach from here →

, UGT2B4

endoplasmic reticulum

One of 2 routes

5alpha-dihydrotestosterone sulfateReach from here →

Catalysed by AKR1B15, HSD17B3, AKR1C1, STScytosolOne of 4 routes

formateReach from here →

Catalysed by AKR1D1, CYP19A1cytosol

5beta-androstane-3,17-dioneReach from here →

Catalysed by AKR1D1cytosol

17alpha-hydroxyprogesteroneReach from here →

Catalysed by AKR1D1, CYP17A1cytosol, endoplasmic reticulum

estroneReach from here →

Catalysed by AKR1D1, CYP19A1cytosol, endoplasmic reticulumOne of 2 routes

testosteroneReach from here →

Catalysed by AKR1D1, HSD17B6, HSD17B1, HSD17B3 and 5 morecytosolOne of 4 routes

androst-5-en-3beta,17beta-diolReach from here →

Catalysed by AKR1B15, HSD17B3, AKR1C1, HSD3B1 and 1 morecytosolOne of 3 routes

19-hydroxyandrost-4-ene-3,17-dioneReach from here →

Catalysed by AKR1D1, CYP19A1cytosolOne of 2 routes

16alpha-hydroxyandrost-4-ene-3,17-dioneReach from here →

Catalysed by AKR1D1, CYP17A1cytosol

3beta,16alpha-dihydroxy-androst-5-en-17-oneReach from here →

Catalysed by AKR1C4, AKR1C3, AKR1C2, AKR1C1 and 1 morecytosol, endoplasmic reticulum

11beta-hydroxyandrost-4-ene-3,17-dioneReach from here →

Catalysed by AKR1D1, CYP11B1cytosol

formic acidReach from here →

Catalysed by AKR1D1, CYP19A1cytosol, endoplasmic reticulum

5alpha-androstane-3alpha,17beta-diolReach from here →

Catalysed by AKR1C4, AKR1C3, AKR1C2, AKR1C1cytosolOne of 5 routes

6beta-hydroxyandrost-4-ene-3,17-dioneReach from here →

Catalysed by AKR1D1, CYP3A4, CYP3A5cytosol

Catalysed by AKR1D1, CYP19A1, CYP3A4cytosol, endoplasmic reticulumOne of 4 routes

estrone 3-O-(beta-D-glucuronate)Reach from here →

Catalysed by AKR1D1, CYP19A1, UGT1A1, UGT1A10 and 1 morecytosol, endoplasmic reticulumOne of 2 routes

testosterone 17-O-(beta-D-glucuronate)Reach from here →

Catalysed by AKR1D1, HSD17B6, HSD17B1, HSD17B3 and 11 morecytosol, endoplasmic reticulumOne of 2 routes

5alpha-dihydrotestosterone 17-O-[beta-D-glucuronosyl-(1->2)-glucuronate]Reach from here →

Catalysed by AKR1B15, HSD17B3, AKR1C1, UGT2B4 and 4 moreendoplasmic reticulum

acetoacetateReach from here →

Catalysed by AKR1D1, CYP19A1, SLC16A4, SLC16A5cytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

1beta-hydroxytestosteroneReach from here →

Catalysed by AKR1D1, HSD17B6, HSD17B1, HSD17B3 and 6 morecytosol

2beta-hydroxytestosteroneReach from here →

Catalysed by AKR1D1, HSD17B6, HSD17B1, HSD17B3 and 6 morecytosol

17beta-hydroxy-androst-5-en-3-oneReach from here →

Catalysed by AKR1D1, HSD17B6, HSD17B1, HSD17B3 and 6 morecytosolOne of 2 routes

acetaldehydeReach from here →

Catalysed by AKR1D1, CYP17A1cytosol, endoplasmic reticulum

pyruvateReach from here →

Catalysed by AKR1D1, CYP19A1, SLC16A4, SLC16A5 and 3 morecytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

all-trans-retinoic acidReach from here →

Catalysed by AKR1D1, CYP19A1, SLC16A4, SLC16A5cytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

10-formyltetrahydrofolic acidReach from here →

Catalysed by AKR1D1, CYP19A1, MTHFD1cytosol, endoplasmic reticulumOne of 2 routes

sulfateReach from here →

Catalysed by AKR1C4, AKR1C3, AKR1C2, AKR1C1 and 1 morecytosolOne of 6 routes

(17R,20S)-17,20-dihydroxypregn-4-en-3-oneReach from here →

Catalysed by AKR1D1, CYP17A1, AKR1C1cytosol, endoplasmic reticulumOne of 2 routes

17beta-estradiolReach from here →

Catalysed by AKR1D1, HSD17B6, HSD17B1, HSD17B3 and 6 morecytosol, endoplasmic reticulumOne of 7 routes

formaldehydeReach from here →

Catalysed by AKR1D1, CYP19A1, ALDH9A1cytosol

(R)-3-hydroxybutyric acidReach from here →

Catalysed by AKR1D1, CYP19A1, SLC16A4, SLC16A5 and 2 morecytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

17alpha-estradiolReach from here →

Catalysed by AKR1D1, CYP19A1, DHRS1cytosol, endoplasmic reticulum

testosterone 17-sulfateReach from here →

Catalysed by AKR1D1, HSD17B6, HSD17B1, HSD17B3 and 6 morecytosol

(6R)-10-formyltetrahydrofolateReach from here →

Catalysed by AKR1D1, CYP19A1, MTHFD1, MTHFD1Lcytosol

5beta-dihydrotestosteroneReach from here →

Catalysed by AKR1D1, HSD17B6, HSD17B1, HSD17B3 and 5 morecytosol

androst-4-ene-3,11,17-trioneReach from here →

Catalysed by AKR1D1, CYP11B1, HSD11B2cytosolOne of 2 routes

11-deoxycortisolReach from here →

Catalysed by AKR1D1, CYP17A1, CYP21A2cytosol, endoplasmic reticulumOne of 3 routes

chlorine(.)Reach from here →

Catalysed by AKR1D1, CYP19A1, SLC26A4cytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

acetateReach from here →

Catalysed by AKR1D1, CYP17A1cytosol, endoplasmic reticulumOne of 6 routes

oxalateReach from here →

Catalysed by AKR1D1, CYP19A1, SLC26A6cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

propionic acidReach from here →

Catalysed by AKR1D1, CYP19A1, SLC16A4, SLC16A5 and 1 morecytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

butyric acidReach from here →

Catalysed by AKR1D1, CYP19A1, SLC16A4, SLC16A5cytosol, endoplasmic reticulum, extracellular spaceOne of 2 routes

16alpha,17beta-dihydroxyandrost-4-en-3-oneReach from here →

Catalysed by AKR1D1, HSD17B6, HSD17B1, HSD17B3 and 6 morecytosol