chlorine(.)

Three steps

• 8-hydroperoxy-(5Z,9E,11Z,14Z)-eicosatetraenoateReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. arachidonate to 8-peroxy-(5Z,9E,11Z,14Z)-eicosatetraenoate conversion

  Catalysed by SLC6A14extracellular space, cytosol, endoplasmic reticulumOne of 2 routes

• N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamideReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. 5-phospho-beta-D-ribosylamine + glycine + ATP = N(1)-(5-phospho-beta-D-ribosyl)glycinamide + ADP + phosphate + H(+)
  3. N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6R)-10-formyltetrahydrofolate = N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + (6S)-5,6,7,8-tetrahydrofolate + H(+)

  Catalysed by SLC6A9, SLC6A14, GARTextracellular space, cytosol

• kinetensin-(1-8)Reach from here →
  1. Transport of L-Phenylalanine by Atb0 Transporter
  2. Chymase
  3. kinetensin + H2O = kinetensin-(1-8) + L-leucine

  Catalysed by SLC6A14, CMA1, ACE2extracellular space, cytosol

• N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serineReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + L-serine

  Catalysed by SLC6A14, FAAH, PM20D1extracellular space, cytosol, endoplasmic reticulum

• (7Z)-octadecenoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. carnitine O-palmitoyltransferase ((7Z)-octadecenoyl-CoA)

  Catalysed by SLC6A6, BAAT, CPT1A, CPT1C and 1 moreextracellular space, cytosol, peroxisomeOne of 3 routes

• CHEBI:15345Reach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Acetoacetate:CoA ligase (AMP-forming)

  Catalysed by SLC6A6, BAAT, AACSextracellular space, cytosol, peroxisomeOne of 5 routes

• acetoneReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of acetoacetate and formate (cytosol to extracellular)
  3. Acetoacetate carboxy-lyase (acetone-forming)

  Catalysed by SLC26A4, SLC16A4, SLC16A5extracellular space, cytosol, mitochondrial matrix

• acetylpyruvateReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. acetylpyruvate + H2O = acetate + pyruvate + H(+)

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A7 and 3 moreextracellular space, cytosolOne of 2 routes

• CHEBI:15380Reach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. 5-aminolevulinate synthase (2-amino-3-oxoadipate)

  Catalysed by SLC6A6, BAAT, ALAS1, CPNE7extracellular space, cytosol, peroxisome, mitochondrial matrixOne of 8 routes

• 2-methylcrotonoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Production of Tiglylcarnitine

  Catalysed by SLC6A6, BAAT, CPT1A, CPT1Bextracellular space, cytosol, peroxisomeOne of 3 routes

• isobutyryl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. acetyl-CoA C-acyltransferase (3-oxo-4-methyl-pentanoyl-CoA)

  Catalysed by SLC6A6, BAAT, HADHA, ACAA2 and 1 moreextracellular space, cytosol, peroxisome, mitochondrial matrixOne of 3 routes

• 3-methylbut-2-enoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. glycine-N-acyltransferase (3-methylcrotonoylglycine)

  Catalysed by SLC6A6, BAAT, GLYATextracellular space, cytosol, peroxisome, mitochondrial matrix

• isovaleryl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. glycine N-acyltransferase (isovalerylglycine)

  Catalysed by SLC6A6, BAAT, GLYAT, GLYATL2 and 1 moreextracellular space, cytosol, peroxisome, mitochondrial matrixOne of 3 routes

• arachidonoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Arachidonate:CoA ligase (AMP-forming)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 14 routes

• CHEBI:15519Reach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. propanoyl-CoA C-acyltransferase

  Catalysed by SLC6A6, BAAT, ACAA1, SCP2 and 1 moreextracellular space, cytosol, peroxisomeOne of 2 routes

• palmitoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Palmitate:CoA ligase (AMP-forming)

  Catalysed by SLC6A6, BAAT, SLC27A2, ACSL4 and 6 moreextracellular space, cytosol, peroxisomeOne of 18 routes

• oleoyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Transport of octadecenoyl-CoA into Mitochondrial Matrix

  Catalysed by SLC6A6, BAAT, CPT1A, CPT1C and 1 moreextracellular space, cytosol, peroxisomeOne of 14 routes

• phenylacetyl-CoAReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Phenylacetate:CoA ligase

  Catalysed by SLC6A6, BAATextracellular space, cytosol, peroxisomeOne of 4 routes

• D-threo-isocitrateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  3. citrate = D-threo-isocitrate

  Catalysed by SLC26A6, SLC25A1, ACO1, ACO2extracellular space, cytosol, mitochondrial matrixOne of 3 routes

• 12(S)-HPETEReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. arachidonate:oxygen 12-oxidoreductase

  Catalysed by SLC6A14, ALOX12extracellular space, cytosol, endoplasmic reticulumOne of 4 routes

• 15(S)-HPETEReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. arachidonate:oxygen 15-oxidoreductase

  Catalysed by SLC6A14, ALOX15B, ALOX15extracellular space, cytosol, endoplasmic reticulumOne of 4 routes

• 5(S)-HPETEReach from here →
  1. Carnitine Transport by Atb0
  2. Utilized Transport
  3. Arachidonate:oxygen 5-oxidoreductase

  Catalysed by SLC6A14, ALOX5extracellular space, cytosol, endoplasmic reticulum

• (6R)-5,10-methylene-5,6,7,8-tetrahydrofolateReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine
  3. (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine

  Catalysed by SLC6A9, SLC6A14, SHMT1, SHMT2extracellular space, cytosolOne of 2 routes

• 5-methyltetrahydrofolic acidReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. 5,10-Methylenetetrahydrofolate:glycine hydroxymethyltransferase
  3. histamine N-methyltransferase (SAM)

  Catalysed by SLC6A9, SLC6A14, SHMT1, HNMTextracellular space, cytosol

• CHEBI:15650Reach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. N-acetyl-LTE4 to leukotriene E4 conversion

  Catalysed by SLC6A6, BAAT, ZDHHC11B, NAA10 and 30 moreextracellular space, cytosol, peroxisomeOne of 6 routes

• trans-aconitateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  3. trans-aconitate(in) + citrate(out) = trans-aconitate(out) + citrate(in)

  Catalysed by SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• formateReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. oxalate(in) + sulfate(out) = oxalate(out) + sulfate(in)
  3. oxalate(in) + formate(out) = oxalate(out) + formate(in)

  Catalysed by SLC26A6, SLC25A14, SLC26A2, SLC25A30 and 1 moreextracellular space, cytosol, inner side of the membrane, outer side of the membraneOne of 3 routes

• CHEBI:15746Reach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. diamine N-acetyltransferase (N1-acetylspermine)

  Catalysed by SLC6A6, BAAT, SAT1, SAT2extracellular space, cytosol, peroxisomeOne of 2 routes

• nicotinic acid D-ribonucleotideReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. Transport of Quinolinic Acid
  3. Nicotinate-nucleotide:pyrophosphate phosphoribosyltransferase (carboxylating)

  Catalysed by SLC26A6, SLC22A6, QPRTextracellular space, cytosol

• 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoateReach from here →
  1. Transport of L-Tryptophan by Atb0 Transporter
  2. Transport of 3-Hydroxy-L-Kynurenine
  3. 3-hydroxy-L-kynurenine:2-oxoglutarate aminotransferase

  Catalysed by SLC6A14, SLC7A5, KYAT1, KYAT3 and 1 moreextracellular space, cytosol

• 3-hydroxyanthranilic acidReach from here →
  1. Transport of L-Tryptophan by Atb0 Transporter
  2. Transport of 3-Hydroxy-L-Kynurenine
  3. 3-Hydroxy-L-kynurenine hydrolase

  Catalysed by SLC6A14, SLC7A5, KYNUextracellular space, cytosol

• bromideReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. 2-bromoacetaldehyde:glutathione S-(formylmethyl)transferase

  Catalysed by SLC6A9, SLC6A14, GSS, MGST3 and 16 moreextracellular space, cytosolOne of 2 routes

• N-carbamoyl-L-aspartic acidReach from here →
  1. transport of chloride (cytosol to extracellular)
  2. transport of aspartate (cytosol to extracellular)
  3. carbamoyl-phosphate:L-aspartate carbamoyltransferase

  Catalysed by SLC12A2, SLC12A1, SLC1A7, SLC1A3 and 4 moreextracellular space, cytosolOne of 2 routes

• keto-D-fructose 6-phosphateReach from here →
  1. Transport of L-Glutamine by Atb0 Transporter
  2. L-glutamine:D-fructose-6-phosphate isomerase (deaminating)
  3. D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing)

  Catalysed by SLC6A14, GFPT2, GFPT1, GNPDA1 and 1 moreextracellular space, cytosol

• thioredoxin dithiolReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. glycine:tRNA(Gly) ligase (AMP-forming)
  3. glycyl-tRNA(gly) phosphorylation

  Catalysed by SLC6A9, SLC6A14, GARS1extracellular space, cytosolOne of 18 routes

• methanethiolReach from here →
  1. transport of chloride and cysteine (cytosol to extracellular)
  2. L-cysteine hydrogen-sulfide-lyase (deaminating
  3. methanethiol + O2 + H2O = hydrogen sulfide + formaldehyde + H2O2 + H(+)

  Catalysed by SLC6A14, CTH, SELENBP1extracellular space, cytosol

• androsteroneReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. steroid sulfatase (androsterone sulfate)
  3. steroid sulfatase (androsterone sulfate)

  Catalysed by SLC26A6, STSextracellular space, cytosolOne of 3 routes

• a halide anionReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine + glycine + ATP = glutathione + ADP + phosphate + H(+)
  3. RX + glutathione = an S-substituted glutathione + a halide anion + H(+)

  Catalysed by SLC6A9, SLC6A14, GSS, GSTT4 and 22 moreextracellular space, cytosol

• CHEBI:16132Reach from here →
  1. Transport of L-Threonine by Atb0 Transporter
  2. L-threonine acetaldehyde-lyase (glycine-forming)
  3. deoxyribose-phosphate aldolase

  Catalysed by SLC6A14, DERAextracellular space, cytosol

• homogentisateReach from here →
  1. Transport of L-Tyrosine by Atb0 Transporter
  2. L-tyrosine:2-oxoglutarate aminotransferase
  3. 4-Hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating,decarboxylating)

  Catalysed by SLC6A14, GOT2, GOT1, TAT and 1 moreextracellular space, cytosolOne of 2 routes

• 2-methyl-3-oxopropanoic acidReach from here →
  1. transport of chloride and formate (cytosol to extracellular)
  2. transport of formate and pyruvate (cytosol to extracellular)
  3. (R)-3-Amino-2-methylpropanoate:pyruvate aminotransferase

  Catalysed by SLC26A4, SLC16A4, SLC16A5, SLC16A7 and 3 moreextracellular space, cytosol, mitochondrial matrixOne of 3 routes

• nitriteReach from here →
  1. transport of arginine and chloride (cytosol to extracellular)
  2. L-Arginine, NADPH:Oxygen Oxidoreductase (Nitric-Oxide-Forming)
  3. 4 nitric oxide + O2 + 2 H2O = 4 nitrite + 4 H(+)

  Catalysed by SLC6A14, NOS3, NOS1, NOS2 and 1 moreextracellular space, cytosol

• 11-cis-retinolReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. Choloyl-CoA:glycine N-choloyltransferase
  3. Palmitoyl-CoA:retinol O-acyltransferase

  Catalysed by SLC6A6, BAAT, DGAT1, LRAT and 3 moreextracellular space, cytosol, peroxisome

• cob(II)alaminReach from here →
  1. Neurotransmitter:Sodium Symporter (Nss) Tcdb:2.A.22.3.3
  2. uridine(34) in tRNA + 5,10-methylenetetrahydrofolate + taurine + GTP + A + H2O = 5-taurinomethyluridine(34) in tRNA + 7,8-dihydrofolate + GDP + AH2 + phosphate + H(+)
  3. 2 cob(II)alamin + A + 2 H2O + 2 H(+) = 2 aquacob(III)alamin + AH2

  Catalysed by SLC6A6, MTO1, MTRRextracellular space, cytosol

• lithocholic acidReach from here →
  1. transport of chloride and glycine (cytosol to extracellular)
  2. gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)
  3. transport of GSH and lithocholate (cytosol to extracellular)

  Catalysed by SLC6A9, SLC6A14, GSS, SLCO1A2 and 1 moreextracellular space, cytosolOne of 2 routes

• 17beta-hydroxy-5alpha-androstan-3-oneReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. steroid sulfatase (5-alpha-dihydrotestosterone)
  3. steroid sulfatase (5-alpha-dihydrotestosterone)

  Catalysed by SLC26A6, STSextracellular space, cytosolOne of 3 routes

• cis-aconitateReach from here →
  1. transport of chloride and oxalate (cytosol to extracellular)
  2. Mitochondrial Carrier (Mc) Tcdb:2.A.29.7.2
  3. cis-aconitate(in) + citrate(out) = cis-aconitate(out) + citrate(in)

  Catalysed by SLC26A6, SLC25A1extracellular space, cytosol, mitochondrial matrix, inner side of the membrane, outer side of the membraneOne of 2 routes

• ubiquinonesReach from here →
  1. transport of chloride and sulfate (cytosol to extracellular)
  2. transport of fumarate and sulfate (cytosol to mitochondria)
  3. succinate:quinone oxidoreductase

  Catalysed by SLC26A6, SLC25A10, SDHD, SDHB and 2 moreextracellular space, cytosol, mitochondrial matrix

• 2-phenylacetaldehydeReach from here →
  1. Transport of L-Phenylalanine by Atb0 Transporter
  2. L-phenylalanine carboxy-lyase (phenylethylamine-forming)
  3. Phenethylamine:oxygen oxidoreductase (deaminating)

  Catalysed by SLC6A14, DDC, AOC2, AOC1 and 3 moreextracellular space, cytosolOne of 2 routes

• CHEBI:16436Reach from here →
  1. transport of chloride and choline (cytosol to extracellular)
  2. ATP:choline phosphotransferase
  3. CTP:choline-phosphate cytidylyltransferase

  Catalysed by SLC5A7, CHKA, CHKB, PCYT1A and 1 moreextracellular space, cytosol