12(S)-HPETE

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

106 compounds within 3 steps: 1 in 1, 6 in 2, 99 in 3

One step

glutathione disulfideReach from here →
1. arachidonate 12-lipoxygenase, 12S type (12(S)-HPETE)
Catalysed by ALOX12cytosolOne of 2 routes

Two steps

15(S)-HPETEReach from here →
1. arachidonate 12-lipoxygenase, 12S type (12(S)-HPETE)
2. Glutathione: 15-HPETE oxidoreductase
Catalysed by ALOX12, GPX5, GPX1, GPX2 and 6 morecytosol
L-cystineReach from here →
1. arachidonate 12-lipoxygenase, 12S type (12(S)-HPETE)
2. cystine to cysteine conversion
Catalysed by ALOX12cytosol
CHEBI:16856Reach from here →
1. arachidonate 12-lipoxygenase, 12S type (12(S)-HPETE)
2. Glutathione: 15-HPETE oxidoreductase
Catalysed by ALOX12, GPX5, GPX1, GPX2 and 6 morecytosolOne of 7 routes
methylarsonateReach from here →
1. arachidonate 12-lipoxygenase, 12S type (12(S)-HPETE)
2. methylarsonate + 2 glutathione + H(+) = methylarsonous acid + glutathione disulfide + H2O
Catalysed by ALOX12, GSTO1, GSTO2cytosol
thiosulfateReach from here →
1. arachidonate 12-lipoxygenase, 12S type (12(S)-HPETE)
2. thiosulfate + 2 glutathione = glutathione disulfide + hydrogen sulfide + sulfite + 2 H(+)
Catalysed by ALOX12, TSTD1cytosol
glutathioneReach from here →
1. arachidonate 12-lipoxygenase, 12S type (12(S)-HPETE)
2. 2 glutathione + NADP(+) = glutathione disulfide + NADPH + H(+)
Catalysed by ALOX12, GSRcytosolOne of 4 routes

Three steps

Catalysed by ALOX12, GSR, GPX1, GPX2 and 1 morecytosol

tauroursodeoxycholateReach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 3 routes

glycoursodeoxycholateReach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 3 routes

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 6 morecytosolOne of 2 routes

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 27 morecytosolOne of 5 routes

prostaglandin E3Reach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

prostaglandin A2Reach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

prostaglandin B1Reach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

leukotriene F4Reach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 6 morecytosol, extracellular spaceOne of 2 routes

prostaglandin A2-S-(R)-glutathioneReach from here →

Catalysed by ALOX12, GSR, GSTA1, GSTM1cytosol

prostaglandin A2-S-(S)-glutathioneReach from here →

Catalysed by ALOX12, GSR, GSTP1, GSTM1cytosol

prostaglandin J2-S-(R)-glutathioneReach from here →

Catalysed by ALOX12, GSR, GSTA1, GSTP1 and 1 morecytosol

prostaglandin J2-S-(S)-glutathioneReach from here →

Catalysed by ALOX12, GSR, GSTP1, GSTM1cytosol

2,4-dinitrophenyl-S-glutathioneReach from here →

Catalysed by ALOX12, GSR, PTGES, LANCL1 and 2 morecytosol

(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →

Catalysed by ALOX12, GSR, GSTM4, LTC4Scytosol

S-methyl glutathioneReach from here →

Catalysed by ALOX12, GSR, MMACHCcytosol

L-cystine-bis-glycineReach from here →

Catalysed by ALOX12, DPEP1, DPEP2cytosol

S-adenosylglutathioneReach from here →

Catalysed by ALOX12, GSR, MMACHCcytosol

acetylcholineReach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

pyruvateReach from here →

Catalysed by ALOX12, CTHcytosol

(S)-malateReach from here →

Catalysed by ALOX12, TSTD1, SLC25A10cytosol, mitochondrial matrixOne of 2 routes

L-leucineReach from here →

Catalysed by ALOX12, SLC7A9, SLC3A1cytosol, extracellular space

CHEBI:15650Reach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 7 morecytosol, extracellular spaceOne of 2 routes

bromideReach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 23 morecytosolOne of 2 routes

a halide anionReach from here →

Catalysed by ALOX12, GSR, GSTT4, GSTA4 and 21 morecytosol

sulfateReach from here →

Catalysed by ALOX12, TSTD1cytosolOne of 3 routes

lithocholic acidReach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

L-arginineReach from here →

Catalysed by ALOX12, SLC7A9cytosol, inner side of the membrane, outer side of the membrane

bilirubin IXalphaReach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

taurolithocholateReach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 8 morecytosol, extracellular spaceOne of 2 routes

CHEBI:17208Reach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 6 morecytosol

homocysteineReach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 6 morecytosol

sulfiteReach from here →

Catalysed by ALOX12, GSR, TSTD1cytosolOne of 6 routes

L-cysteineReach from here →

Catalysed by ALOX12, GPX5, GPX1, GPX2 and 6 morecytosolOne of 4 routes

urateReach from here →

Catalysed by ALOX12, GSR, SLC22A13cytosol, inner side of the membrane, outer side of the membrane

methylarsonous acidReach from here →

Catalysed by ALOX12, GSR, GSTO1, GSTO2cytosolOne of 2 routes

fumaric acidReach from here →

Catalysed by ALOX12, TSTD1, SLC25A10cytosol, mitochondrial matrixOne of 2 routes

thiocyanateReach from here →

Catalysed by ALOX12, TSTD1, MPST, TSTcytosol, mitochondrial matrixOne of 2 routes

arsenic triglutathioneReach from here →

Catalysed by ALOX12, GSR, AS3MTcytosolOne of 3 routes

15-deoxy-Delta(12,14)-prostaglandin J2-S-(R)-glutathioneReach from here →

Catalysed by ALOX12, GSR, MGST3cytosol

(5S)-hydroxy-(6E,8Z,11Z,14Z,17Z)-eicosapentaenoateReach from here →

Catalysed by ALOX12, GSR, GPX1, GPX4cytosol

(12S)-hydroxy-(5Z,8Z,10E,14Z,17Z)-eicosapentaenoateReach from here →

Catalysed by ALOX12, GSR, GPX1, GPX4cytosol