Compound
CHEBI:15345
A 3-oxoacyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of acetoacetic acid.
Definition from ChEBI (CHEBI:15345), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Statements
7 statements
7 statements · 1 reference database · Subject: CHEBI:15345 · Sources: Human-GEM
- (3S)-3-hydroxybutanoyl-CoA is converted to CHEBI:15345CompoundHuman-GEM MAR03166Inferred only
- (3S)-3-hydroxybutanoyl-CoA is converted to CHEBI:15345CompoundHuman-GEM MAR03104Inferred only
- CHEBI:15345 is a substrate of ACAT1ProteinHuman-GEM MAR03885Inferred only
- CHEBI:15345 is a substrate of ACAT2ProteinHuman-GEM MAR03105Inferred only
- CHEBI:15345 is a substrate of ACAT2ProteinHuman-GEM MAR01434Inferred only
- CHEBI:15345 is a substrate of HMGCS1ProteinHuman-GEM MAR01437Inferred only
- CHEBI:15345 is a substrate of HMGCS2ProteinHuman-GEM MAR01573Inferred only
Reactions
11 reactions
CHEBI:15345+CHEBI:11469002CHEBI:15351
Catalysed by ACAT2
Reaction pageReversibleBalancedEC 2.3.1.9cytosol
Human-GEM MAR01434CC BY 4.0Reference data
acetoacetate+ATP+CHEBI:1146900CHEBI:15345+AMP+diphosphate(3-)
Catalysed by AACS
Reaction pageLeft to rightBalancedEC 6.2.1.16cytosol
Human-GEM MAR01436CC BY 4.0Reference data
CHEBI:15345+CHEBI:15351+waterCHEBI:1146900+proton+CHEBI:15467
Catalysed by HMGCS1
Reaction pageLeft to rightBalancedEC 2.3.3.10cytosol
Human-GEM MAR01437CC BY 4.0Reference data
CHEBI:15345+CHEBI:15351+waterCHEBI:1146900+proton+CHEBI:15467
Catalysed by HMGCS2
Reaction pageLeft to rightBalancedEC 2.3.3.10mitochondrial matrix
Human-GEM MAR01573CC BY 4.0Reference data
acetoacetate+ATP+CHEBI:1146900CHEBI:15345+AMP+diphosphate(3-)
Catalysed by AACS
Reaction pageLeft to rightBalancedEC 6.2.1.16mitochondrial matrix
Human-GEM MAR01576CC BY 4.0Reference data
(3S)-3-hydroxybutanoyl-CoA+NAD(+)CHEBI:15345+proton+NADH(2-)
Catalysed by ACAA1 & HSD17B4 & EHHADH
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.1.1.211peroxisome
Human-GEM MAR03104CC BY 4.0Reference data
CHEBI:15345+CHEBI:11469002CHEBI:15351
Catalysed by ACAT2
Reaction pageReversibleBalancedEC 2.3.1.9peroxisome
Human-GEM MAR03105CC BY 4.0Reference data
(3S)-3-hydroxybutanoyl-CoA+NAD(+)CHEBI:15345+proton+NADH(2-)
Catalysed by HADHA & HADH & HSD17B10
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.1.1.211mitochondrial matrix
Human-GEM MAR03166CC BY 4.0Reference data
acetoacetate+CHEBI:15380CHEBI:15345+succinate(2-)
Reaction pageLeft to rightBalancedEC 2.8.3.5mitochondrial matrix
Human-GEM MAR03787CC BY 4.0Reference data
CHEBI:15345+CHEBI:11469002CHEBI:15351
Catalysed by ACAT1
Reaction pageReversibleBalancedEC 2.3.1.9mitochondrial matrix
Human-GEM MAR03885CC BY 4.0Reference data
CHEBI:15345+CHEBI:15351+waterCHEBI:1146900+proton+CHEBI:15467
Reaction pageLeft to rightBalancedEC 2.3.3.10peroxisome
Human-GEM MAR04604CC BY 4.0Reference data
Other names
7 names
Resolves to: CHEBI:15345
- Also called
- 3-Acetoacetyl-CoAacetoacetyl CoAAcetoacetyl coenzyme AAcetoacetyl-CoAS-acetoacetyl-CoAS-acetoacetyl-coenzyme A
- Systematic name
- 3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-oxo-4-{[3-oxo-3-({2-[(3-oxobutanoyl)sulfanyl]ethyl}amino)propyl]amino}butyl] dihydrogen diphosphate}