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Proteins/UNIPROT:P42765
In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage..
Function from UniProtKB (P42765), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
191 statements
191 statements · 7 reference databases · Subject: ACAA2 · Sources: Bgee, gene ontology, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
110 reactions
MAM00279c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01219c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or
7 names
Resolves to: ACAA2
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01065CC BY 4.0Reference data
MAM01219c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01176c+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01066CC BY 4.0Reference data
MAM01176c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM01055c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 11 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01067CC BY 4.0Reference data
14,15-epoxy-(5Z,8Z,11Z)-eicosatrienoate+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM00310c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01068CC BY 4.0Reference data
MAM00310c+ATP+CHEBI:1146900+2water+NAD(+)+dioxygenMAM00259c+CHEBI:15351+AMP+2proton+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightBalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01069CC BY 4.0Reference data
MAM00259c+ATP+CHEBI:1146900+proton+2water+NAD(+)+dioxygenMAM01210c+CHEBI:15351+AMP+hydrogen peroxide+NADH(2-)+diphosphate(3-)
Catalysed by ACAA1 or HSD17B10 or HADHA or ACOX3 or ACOT7 or ACOT8 or ACOT2 or ECHS1 or SLC27A1 or HSD17B4 or BAAT or HADHB and 12 more alternatives
Reaction pageLeft to rightUnbalancedEC 1.1.1.35, 1.3.3.6, 2.3.1.176, 2.3.1.16, 3.1.2.2, 4.2.1.17, 5.1.99.4, 6.2.1.-cytosol
Human-GEM MAR01070CC BY 4.0Reference data
MAM00740m+CHEBI:1146900MAM00836m+CHEBI:15351
Catalysed by HADHA & ACAA2 & HADHB
Reaction pageLeft to rightBalancedEC 2.3.1.16, 1.1.1.211mitochondrial matrix
Human-GEM MAR01167CC BY 4.0Reference data
MAM00835m+CHEBI:1146900MAM01201m+CHEBI:15351
Catalysed by HADHA & ACAA2 & HADHB
Reaction pageLeft to rightBalancedEC 2.3.1.16, 1.1.1.211mitochondrial matrix
Human-GEM MAR01174CC BY 4.0Reference data
MAM00850m+CHEBI:1146900MAM01146m+CHEBI:15351
Catalysed by HADHA & ACAA2 & HADHB
Reaction pageLeft to rightBalancedEC 2.3.1.16, 1.1.1.211mitochondrial matrix
Human-GEM MAR01179CC BY 4.0Reference data
MAM00847m+CHEBI:1146900MAM00935m+CHEBI:15351
Catalysed by HADHA & ACAA2 & HADHB
Reaction pageLeft to rightBalancedEC 2.3.1.16, 1.1.1.211mitochondrial matrix
Human-GEM MAR01184CC BY 4.0Reference data
MAM00741m+CHEBI:1146900MAM00838m+CHEBI:15351
Catalysed by HADHA & ACAA2 & HADHB
Reaction pageLeft to rightBalancedEC 2.3.1.16, 1.1.1.211mitochondrial matrix
Human-GEM MAR01210CC BY 4.0Reference data
MAM00837m+CHEBI:1146900MAM01206m+CHEBI:15351
Catalysed by HADHA & ACAA2 & HADHB
Reaction pageLeft to rightBalancedEC 2.3.1.16, 1.1.1.211mitochondrial matrix
Human-GEM MAR01216CC BY 4.0Reference data