Compound
CHEBI:15380
An ω-carboxyacyl-CoA having succinoyl as the S-acyl component.
Definition from ChEBI (CHEBI:15380), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
16 entities
16 entities reached.
0 reported hops16 assembled from the scaffold
- ALAS1ProteinUNIPROT:P13196substrate ofInferred only52 paths26 endpoints
- DLSTProteinUNIPROT:P36957substrate ofInferred only42 paths42 endpoints
- CPT1AProteinUNIPROT:P50416substrate ofInferred only28 paths28 endpoints
- SUCLG2ProteinUNIPROT:Q96I99substrate ofInferred only24 paths12 endpoints
- ACOT8ProteinUNIPROT:O14734substrate ofInferred only16 paths16 endpoints
- SUCLG1ProteinUNIPROT:P53597substrate ofInferred only14 paths7 endpoints
- OXCT1ProteinUNIPROT:P55809substrate ofInferred only12 paths12 endpoints
- SUCLA2ProteinUNIPROT:Q9P2R7substrate ofInferred only10 paths5 endpoints
- CPNE7ProteinUNIPROT:Q9UBL6substrate ofInferred only10 paths5 endpoints
- DBIProteinUNIPROT:P07108transported byInferred only9 paths9 endpoints
- ALAS2ProteinUNIPROT:P22557substrate ofInferred only9 paths9 endpoints
- ACOT4ProteinUNIPROT:Q8N9L9substrate ofInferred only9 paths9 endpoints
What the reference databases state
Statements
28 statements
28 statements · 1 reference database · Subject: CHEBI:15380 · Sources: Human-GEM
- (R)-methylmalonyl-CoA is converted to CHEBI:15380CompoundHuman-GEM MAR03215Inferred only
- CHEBI:1146900 is converted to CHEBI:15380CompoundHuman-GEM MAR06846Inferred only
- CHEBI:15380 is converted to CHEBI:1146900CompoundHuman-GEM MAR04147Inferred only
- CHEBI:15380 is converted to CHEBI:1146900CompoundHuman-GEM MAR06852Inferred only
- CHEBI:1146900 is converted to CHEBI:15380CompoundHuman-GEM MAR04147Inferred only
- CHEBI:1146900 is converted to CHEBI:15380CompoundHuman-GEM MAR04152Inferred only
- CHEBI:15380 is converted to CHEBI:1146900CompoundHuman-GEM MAR04152Inferred only
- CHEBI:15380 is a substrate of ACOT4ProteinHuman-GEM MAR06852Inferred only
- CHEBI:15380 is a substrate of ACOT8ProteinHuman-GEM MAR06852Inferred only
- CHEBI:15380 is a substrate of ALAS1ProteinHuman-GEM MAR03939Inferred only
- CHEBI:15380 is a substrate of ALAS1ProteinHuman-GEM MAR04742Inferred only
- CHEBI:15380 is a substrate of ALAS2ProteinHuman-GEM MAR04742Inferred only
Show the remaining 16
- CHEBI:15380 is a substrate of CPNE7ProteinHuman-GEM MAR03939Inferred only
- CHEBI:15380 is a substrate of CPNE7ProteinHuman-GEM MAR04742Inferred only
- CHEBI:15380 is a substrate of CPT1AProteinHuman-GEM MAR05456Inferred only
- CHEBI:15380 is a substrate of CPT1BProteinHuman-GEM MAR05456Inferred only
- CHEBI:15380 is a substrate of CPT1CProteinHuman-GEM MAR05456Inferred only
- CHEBI:15380 is a substrate of CROTProteinHuman-GEM MAR06847Inferred only
- CHEBI:15380 is a substrate of DLSTProteinHuman-GEM MAR06414Inferred only
- CHEBI:15380 is a substrate of OXCT1ProteinHuman-GEM MAR03787Inferred only
- CHEBI:15380 is a substrate of OXCT2ProteinHuman-GEM MAR03787Inferred only
- CHEBI:15380 is a substrate of SUCLA2ProteinHuman-GEM MAR04152Inferred only
- CHEBI:15380 is a substrate of SUCLA2ProteinHuman-GEM MAR04147Inferred only
- CHEBI:15380 is a substrate of SUCLG1ProteinHuman-GEM MAR04147Inferred only
- CHEBI:15380 is a substrate of SUCLG1ProteinHuman-GEM MAR04152Inferred only
- CHEBI:15380 is a substrate of SUCLG2ProteinHuman-GEM MAR04147Inferred only
- CHEBI:15380 is a substrate of SUCLG2ProteinHuman-GEM MAR04152Inferred only
- CHEBI:15380 is transported by DBIProteinHuman-GEM MAR07757Inferred only
Reactions
13 reactions
(R)-methylmalonyl-CoACHEBI:15380
Catalysed by MMUT
Reaction pageLeft to rightBalancedEC 5.4.99.2mitochondrial matrix
Human-GEM MAR03215CC BY 4.0Reference data
acetoacetate+CHEBI:15380CHEBI:15345+succinate(2-)
Reaction pageLeft to rightBalancedEC 2.8.3.5mitochondrial matrix
Human-GEM MAR03787CC BY 4.0Reference data
MAM00630m+CHEBI:1146900glycine+CHEBI:15380
Reaction pageReversibleBalancedEC 2.3.1.37mitochondrial matrix
Human-GEM MAR03939CC BY 4.0Reference data
CHEBI:1146900+GTP+succinate(2-)GDP+phosphate(3-)+CHEBI:15380
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.4mitochondrial matrix
Human-GEM MAR04147CC BY 4.0Reference data
ADP+phosphate(3-)+CHEBI:15380ATP+CHEBI:1146900+succinate(2-)
Catalysed by SUCLG1 & SUCLG2 or SUCLG1 & SUCLA2
Reaction pageReversibleBalancedEC 6.2.1.5mitochondrial matrix
Human-GEM MAR04152CC BY 4.0Reference data
glycine+proton+CHEBI:153805-aminolevulinic acid+carbon dioxide+CHEBI:1146900
Catalysed by ALAS1 or ALAS2 or CPNE7
Reaction pageLeft to rightBalancedEC 2.3.1.37mitochondrial matrix
Human-GEM MAR04742CC BY 4.0Reference data
(S)-carnitine+CHEBI:15380CHEBI:1146900+MAM03495c
Catalysed by CPT1A or CPT1C or CPT1B
Reaction pageReversibleBalancedEC 2.3.1.21cytosol
Human-GEM MAR05456CC BY 4.0Reference data
CHEBI:1146900+FAD+water+NAD(+)+hexanedioyl-CoACHEBI:15351+FADH2+proton+NADH(2-)+CHEBI:15380
Catalysed by ACAA1 & EHHADH & ACOX1 or SCP2 & EHHADH & ACOX1 or ACAA1 & HSD17B4 & ACOX1 or SCP2 & HSD17B4 & ACOX1 or ACOX3 & ACAA1 & EHHADH or ACOX3 & SCP2 & EHHADH or ACOX3 & ACAA1 & HSD17B4 or ACOX3 & SCP2 & HSD17B4
Reaction pageLeft to rightBalancedperoxisome
Human-GEM MAR06285CC BY 4.0Reference data
CHEBI:1146900+MAM02934mMAM01701m+CHEBI:15380
Catalysed by DLST
Reaction pageReversibleBalancedEC 2.3.1.61mitochondrial matrix
Human-GEM MAR06414CC BY 4.0Reference data
ATP+CHEBI:1146900+succinate(2-)AMP+diphosphate(3-)+CHEBI:15380
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR06846CC BY 4.0Reference data
(S)-carnitine+CHEBI:15380CHEBI:1146900+MAM03495x
Catalysed by CROT
Reaction pageReversibleBalancedEC 2.3.1.137peroxisome
Human-GEM MAR06847CC BY 4.0Reference data
water+CHEBI:15380CHEBI:1146900+proton+succinate(2-)
Reaction pageLeft to rightBalancedEC 3.1.2.-peroxisome
Human-GEM MAR06852CC BY 4.0Reference data
Other names
9 names
Resolves to: CHEBI:15380
- Also called
- Coenzyme A, S-(hydrogen butanedioate)S-(3-carboxy-propionyl)-CoAS-(3-carboxypropionyl)-coenzyme-AS-(hydrogen succinyl)-CoAS-(Hydrogen succinyl)coenzyme ASuccinyl coenzyme ASuccinyl-CoASUCCINYL-COENZYME A
- Systematic name
- 3'-phosphoadenosine 5'-{3-[(3R)-4-{[3-({2-[(3-carboxypropanoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-3-hydroxy-2,2-dimethyl-4-oxobutyl] dihydrogen diphosphate}