Compound

cob(II)alamin

A cobalamin in which the central cobalt atom has an oxidation state of +2.

Definition from ChEBI (CHEBI:16304), read 2026-09-23. CC BY 4.0.

CHEBI:16304ChEBI

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Structure

2D depiction

No three-dimensional record for this entry.

Class: Organic compound
Formula: C62H88CoN13O14P
Mass: 1329.37 g/mol
Charge: 0
InChIKey: ASARMUCNOOHMLO-DSRCUDDDSA-L
SMILES: [H][C@]12[C@H](CC(N)=O)[C@@]3(C)CCC(=O)NC[C@@H](C)OP(=O)([O-])O[C@H]4[C@@H](O)[C@H](O[C@@H]4CO)n4c[n+](c5cc(C)c(C)cc54)[Co-3]456[N]1C3=C(C)C1=[N+]4C(=CC3=[N+]5C(=C(C)C4=[N+]6[C@]2(C)[C@@](C)(CC(N)=O)[C@@H]4CCC(N)=O)[C@@](C)(CC(N)=O)[C@@H]3CCC(N)=O)C(C)(C)[C@@H]1CCC(N)=O
Look it up: ChEBI By InChIKey

Identity from ChEBI. Not evidence.

What it touches on the way

Mechanistic reach

2 entities

2 entities reached.

0 reported hops2 assembled from the scaffold

What the reference databases state

Statements

4 statements

4 statements · 1 reference database · Subject: cob(II)alamin · Sources: Human-GEM

Order

aquacob(III)alamin is converted to cob(II)alaminCompoundHuman-GEM MAR08613Inferred only
cob(II)alamin is a substrate of MMAAProteinHuman-GEM MAR08615Inferred only
cob(II)alamin is a substrate of MMABProteinHuman-GEM MAR08615Inferred only
cob(II)alamin is transported by MMAAProteinHuman-GEM MAR08614Inferred only

Reactions

10 reactions

cob(II)alamin+S-adenosyl-L-methionineCHEBI:16680+MAM03322c
Reaction pageLeft to rightUnbalancedEC 2.1.1.13cytosol
Human-GEM MAR03138CC BY 4.0Reference data
2aquacob(III)alamin+NADH(2-)2cob(II)alamin+proton+2water+NAD(+)
Reaction pageLeft to rightBalancedcytosol
Human-GEM MAR08613CC BY 4.0Reference data
cob(II)alamincob(II)alamin
Transported by MMAA
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR08614CC BY 4.0Reference data
cob(II)alamin+NADH(2-)MAM01598m+proton+NAD(+)
Catalysed by MMAB or MMAA
Reaction pageReversibleUnbalancedEC 2.5.1.17mitochondrial matrix
Human-GEM MAR08615CC BY 4.0Reference data
2CHEBI:60488+NAD(1-)+hydron2cob(II)alamin+NADH(2-)
Reaction pageDirection not assertedBalanced
Rhea RHEA:17481CC BY 4.0Reference data
2cob(II)alamin+A+2water+2hydron2aquacob(III)alamin+AH2
Catalysed by MTRR
Reaction pageRight to leftBalanced
Rhea RHEA:20752CC BY 4.0Reference data
2cob(II)alamin+reduced [electron-transfer flavoprotein]+2ATP(4-)2adenosylcob(III)alamin+2triphosphate+oxidized [electron-transfer flavoprotein]+3hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:28671CC BY 4.0Reference data
2cob(II)alamin+AH2+2ATP(4-)2adenosylcob(III)alamin+2triphosphate+A+2hydron
Reaction pageDirection not assertedBalanced
Rhea RHEA:53304CC BY 4.0Reference data
apo-[corrinoid adenosyltransferase]+cob(II)alamincob(II)alamin-[corrinoid adenosyltransferase]
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:56788CC BY 4.0Reference data
2cob(II)alamin+reduced [electron-transfer flavoprotein]+2ATP(4-)+2water2adenosylcob(III)alamin+oxidized [electron-transfer flavoprotein]+2hydrogenphosphate+2diphosphate(3-)+3hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:66828CC BY 4.0Reference data

Other names

2 names

Resolves to: cob(II)alamin

Also called: vitamin B-12rVitamin B12r