Compound
12(S)-HPETE
The (S)-enantiomer of 12-HPETE.
Definition from ChEBI (CHEBI:15626), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
9 entities
9 entities reached.
0 reported hops9 assembled from the scaffold
- GPX1ProteinUNIPROT:P07203substrate ofInferred only125 paths25 endpoints
- GPX4ProteinUNIPROT:P36969substrate ofInferred only118 paths20 endpoints
- GPX2ProteinUNIPROT:P18283substrate ofInferred only108 paths27 endpoints
- PRDX6ProteinUNIPROT:P30041substrate ofInferred only60 paths15 endpoints
- ALOX12ProteinUNIPROT:P18054substrate ofInferred only56 paths28 endpoints
- GPX3ProteinUNIPROT:P22352substrate ofInferred only52 paths13 endpoints
- GPX6ProteinUNIPROT:P59796substrate ofInferred only32 paths8 endpoints
- GPX5ProteinUNIPROT:O75715substrate ofInferred only24 paths6 endpoints
- GPX7ProteinUNIPROT:Q96SL4substrate ofInferred only8 paths2 endpoints
What the reference databases state
Statements
45 statements
45 statements · 1 reference database · Subject: 12(S)-HPETE · Sources: Human-GEM
- (5Z,8Z,11Z,14Z)-eicosatetraenoate is converted to 12(S)-HPETECompoundHuman-GEM MAR01029Inferred only
- (5Z,8Z,11Z,14Z)-eicosatetraenoate is converted to 12(S)-HPETECompoundHuman-GEM MAR01030Inferred only
- (5Z,8Z,11Z,14Z)-eicosatetraenoate is converted to 12(S)-HPETECompoundHuman-GEM MAR01033Inferred only
- (5Z,8Z,11Z,14Z)-eicosatetraenoate is converted to 12(S)-HPETECompoundHuman-GEM MAR01034Inferred only
- 12(S)-HPETE is a substrate of ALOX12ProteinHuman-GEM MAR01039Inferred only
- 12(S)-HPETE is a substrate of ALOX12ProteinHuman-GEM MAR01037Inferred only
- 12(S)-HPETE is a substrate of GPX1ProteinHuman-GEM MAR01043Inferred only
- 12(S)-HPETE is a substrate of GPX1ProteinHuman-GEM MAR03918Inferred only
- 12(S)-HPETE is a substrate of GPX1ProteinHuman-GEM MAR01049Inferred only
- 12(S)-HPETE is a substrate of GPX1ProteinHuman-GEM MAR01048Inferred only
- 12(S)-HPETE is a substrate of GPX1ProteinHuman-GEM MAR01045Inferred only
- 12(S)-HPETE is a substrate of GPX2ProteinHuman-GEM MAR01045Inferred only
Show the remaining 33
- 12(S)-HPETE is a substrate of GPX2ProteinHuman-GEM MAR01048Inferred only
- 12(S)-HPETE is a substrate of GPX2ProteinHuman-GEM MAR01049Inferred only
- 12(S)-HPETE is a substrate of GPX2ProteinHuman-GEM MAR01043Inferred only
- 12(S)-HPETE is a substrate of GPX3ProteinHuman-GEM MAR01043Inferred only
- 12(S)-HPETE is a substrate of GPX3ProteinHuman-GEM MAR01048Inferred only
- 12(S)-HPETE is a substrate of GPX3ProteinHuman-GEM MAR01045Inferred only
- 12(S)-HPETE is a substrate of GPX3ProteinHuman-GEM MAR01049Inferred only
- 12(S)-HPETE is a substrate of GPX4ProteinHuman-GEM MAR01045Inferred only
- 12(S)-HPETE is a substrate of GPX4ProteinHuman-GEM MAR01048Inferred only
- 12(S)-HPETE is a substrate of GPX4ProteinHuman-GEM MAR01049Inferred only
- 12(S)-HPETE is a substrate of GPX4ProteinHuman-GEM MAR03924Inferred only
- 12(S)-HPETE is a substrate of GPX4ProteinHuman-GEM MAR03918Inferred only
- 12(S)-HPETE is a substrate of GPX4ProteinHuman-GEM MAR01043Inferred only
- 12(S)-HPETE is a substrate of GPX5ProteinHuman-GEM MAR01048Inferred only
- 12(S)-HPETE is a substrate of GPX5ProteinHuman-GEM MAR01043Inferred only
- 12(S)-HPETE is a substrate of GPX5ProteinHuman-GEM MAR01045Inferred only
- 12(S)-HPETE is a substrate of GPX5ProteinHuman-GEM MAR01049Inferred only
- 12(S)-HPETE is a substrate of GPX6ProteinHuman-GEM MAR01043Inferred only
- 12(S)-HPETE is a substrate of GPX6ProteinHuman-GEM MAR01048Inferred only
- 12(S)-HPETE is a substrate of GPX6ProteinHuman-GEM MAR01049Inferred only
- 12(S)-HPETE is a substrate of GPX6ProteinHuman-GEM MAR01045Inferred only
- 12(S)-HPETE is a substrate of GPX7ProteinHuman-GEM MAR01045Inferred only
- 12(S)-HPETE is a substrate of GPX7ProteinHuman-GEM MAR01048Inferred only
- 12(S)-HPETE is a substrate of GPX7ProteinHuman-GEM MAR01049Inferred only
- 12(S)-HPETE is a substrate of GPX7ProteinHuman-GEM MAR01043Inferred only
- 12(S)-HPETE is a substrate of GPX8ProteinHuman-GEM MAR01049Inferred only
- 12(S)-HPETE is a substrate of GPX8ProteinHuman-GEM MAR01043Inferred only
- 12(S)-HPETE is a substrate of GPX8ProteinHuman-GEM MAR01045Inferred only
- 12(S)-HPETE is a substrate of GPX8ProteinHuman-GEM MAR01048Inferred only
- 12(S)-HPETE is a substrate of PRDX6ProteinHuman-GEM MAR01043Inferred only
- 12(S)-HPETE is a substrate of PRDX6ProteinHuman-GEM MAR01049Inferred only
- 12(S)-HPETE is a substrate of PRDX6ProteinHuman-GEM MAR01048Inferred only
- 12(S)-HPETE is a substrate of PRDX6ProteinHuman-GEM MAR01045Inferred only
Reactions
16 reactions
(5Z,8Z,11Z,14Z)-eicosatetraenoate+dioxygen12(S)-HPETE
Catalysed by ALOX12
Reaction pageLeft to rightBalancedEC 1.13.11.31GO:0005829
Human-GEM MAR01029CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoate+dioxygen12(S)-HPETE
Catalysed by ALOX12
Reaction pageLeft to rightBalancedEC 1.13.11.31GO:0005615
Human-GEM MAR01030CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoate+dioxygen12(S)-HPETE
Catalysed by ALOX12
Reaction pageLeft to rightBalancedEC 1.13.11.31GO:0005783
Human-GEM MAR01033CC BY 4.0Reference data
(5Z,8Z,11Z,14Z)-eicosatetraenoate+dioxygen12(S)-HPETE
Catalysed by ALOX12
Reaction pageLeft to rightBalancedEC 1.13.11.31GO:0005777
Human-GEM MAR01034CC BY 4.0Reference data
12(S)-HPETE+2CHEBI:16856MAM00307c+glutathione disulfide+water
Catalysed by ALOX12
Reaction pageLeft to rightBalancedEC 1.13.11.31GO:0005829
Human-GEM MAR01037CC BY 4.0Reference data
12(S)-HPETE+2CHEBI:16856MAM00307r+glutathione disulfide+water
Catalysed by ALOX12
Reaction pageLeft to rightBalancedEC 1.13.11.31GO:0005783
Human-GEM MAR01039CC BY 4.0Reference data
12(S)-HPETEMAM02098c
Reaction pageReversibleBalancedEC 5.4.4.-GO:0005829
Human-GEM MAR01041CC BY 4.0Reference data
12(S)-HPETEMAM02096c
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9GO:0005829
Human-GEM MAR01043CC BY 4.0Reference data
12(S)-HPETEMAM02096e
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9GO:0005615
Human-GEM MAR01045CC BY 4.0Reference data
12(S)-HPETEMAM02096x
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9GO:0005777
Human-GEM MAR01048CC BY 4.0Reference data
12(S)-HPETEMAM02096r
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageReversibleBalancedEC 1.11.1.9GO:0005783
Human-GEM MAR01049CC BY 4.0Reference data
12(S)-HPETEMAM02096m
Reaction pageReversibleBalancedEC 1.11.1.9GO:0005759
Human-GEM MAR03918CC BY 4.0Reference data
Other names
13 names
Resolves to: 12(S)-HPETE
- Also called
- (5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyeicosa-5,8,10,14-tetraenoate(5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyicosa-5,8,10,14-tetraenoate(5Z,8Z,10E,14Z)-(12S)-12-Hydroperoxyicosa-5,8,10,14-tetraenoic acid12-HpETE12-Hydroperoxyeicosatetraenoate12-Hydroperoxyeicosatetraenoic acid12-Hydroperoxyicosatetraenoate12-Hydroperoxyicosatetraenoic acid12-OoheteArachidonic acid omega-9 hydroperoxideomega-9 Hpaaomega-9-Hydroperoxyarachidonic acid
- Systematic name
- (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoic acid