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Proteins/UNIPROT:Q13621
Renal sodium, potassium and chloride non-electrogenic ion symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. It can substitute NH4(+) for K(+), enabling NH4(+) apical transmembrane transport in the medullary thick ascending limb (MTAL). This function is crucial for maintaining ammonium homeostasis by the kidney, particularly during metabolic acidosis (By similarity)..
Function from UniProtKB (Q13621), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · transported by
2 compounds
2 compounds.
0 reported routes2 assembled routes
1 row
30 statements
30 statements · 6 reference databases · Subject: SLC12A1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea
4 reactions
2chlorine(.)+potassium atom+sodium(1+)2chlorine(.)+potassium atom+sodium(1+)
Transported by SLC12A2 or SLC12A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04956CC BY 4.0Reference data
5 names
Resolves to: SLC12A1
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR06526CC BY 4.0Reference data
K(+)+2chloride+sodium(1+)K(+)+2chloride+sodium(1+)
Transported by SLC12A2 or SLC12A1
Reaction pageLeft to rightBalanced
Rhea RHEA:72395CC BY 4.0Reference data
2chloride+sodium(1+)+ammonium2chloride+sodium(1+)+ammonium
Transported by SLC12A1
Reaction pageDirection not assertedBalanced
Rhea RHEA:85511CC BY 4.0Reference data