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Proteins/UNIPROT:Q16773
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. Also metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond..
Function from UniProtKB (Q16773), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
97 statements
97 statements · 6 reference databases · Subject: KYAT1 · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
7 reactions
L-glutamine+pyruvate2-oxoglutaramate+L-alanine
Catalysed by KYAT1
Reaction pageLeft to rightBalancedEC 2.6.1.15, 2.6.1.63cytosol
Human-GEM MAR04196CC BY 4.0Reference data
2-oxoglutarate(2-)+L-kynureninekynurenate+L-glutamate(1-)+water
9 names
Resolves to: KYAT1
Human-GEM MAR04222CC BY 4.0Reference data
CHEBI:17380+2-oxoglutarate(2-)4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate+L-glutamate(1-)
Catalysed by AADAT or KYAT3 or KYAT1
Reaction pageLeft to rightBalancedEC 2.6.1.7cytosol
Human-GEM MAR04244CC BY 4.0Reference data
CHEBI:17380+2-oxoglutarate(2-)L-glutamate(1-)+water+xanthurenate
Catalysed by AADAT or KYAT3 or KYAT1
Reaction pageReversibleBalancedEC 2.6.1.7cytosol
Human-GEM MAR04246CC BY 4.0Reference data
3-phenylpyruvate+L-glutamine2-oxoglutaramate+L-phenylalanine
Catalysed by KYAT1
Reaction pageDirection not assertedBalanced
Rhea RHEA:17593CC BY 4.0Reference data
an S-substituted L-cysteine+watera thiol+pyruvate+ammonium
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18121CC BY 4.0Reference data
L-kynurenine+2-oxoglutarate(2-)kynurenate+L-glutamate(1-)+water
Catalysed by GOT2 or KYAT1 or KYAT3 or AADAT
Reaction pageLeft to rightBalanced
Rhea RHEA:65560CC BY 4.0Reference data