5-methyltetrahydrofolic acid

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

401 compounds within 3 steps: 5 in 1, 42 in 2, 354 in 3

One step

5,6,7,8-tetrahydrobiopterinReach from here →
1. 5-methyl-THF to 5,10-methylene-THF conversion
No catalyst recordedcytosol
(6R)-5,10-methylenetetrahydrofolic acidReach from here →
1. 5-methyl-THF to 5,10-methylene-THF conversion
No catalyst recordedcytosol
5,6,7,8-tetrahydrofolic acidReach from here →
1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
Catalysed by MTRcytosolOne of 3 routes
selenomethionineReach from here →
1. Methionine Synthase
No catalyst recordednucleusOne of 2 routes
L-methionineReach from here →
1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
Catalysed by MTRcytosol

Two steps

CHEBI:1146900Reach from here →
1. 5-methyltetrahydrofolate:L-homocysteine S-methyltransferase
2. N-acetylglutamate synthase (N-acetylmethionine)
Catalysed by MTR, NAGScytosol, mitochondrial matrix
4a-hydroxytetrahydrobiopterinReach from here →
1. 5-methyl-THF to 5,10-methylene-THF conversion
2. L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase(5-hydroxylating)
Catalysed by TPH1, TPH2cytosolOne of 3 routes
L-leucineReach from here →

Three steps

beta-carbolineReach from here →
Catalysed by MTR, SLC7A5cytosol, extracellular space
(S)-carnitineReach from here →
Catalysed by MTR, NAGS and 1 more

Catalysed by MTR, SLC3A2, SLC7A5cytosol, extracellular spaceOne of 6 routes

10-formyltetrahydrofolic acidReach from here →

Catalysed by MTR, MTHFD1cytosolOne of 3 routes

CHEBI:15699Reach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 3 routes

CHEBI:15765Reach from here →

Catalysed by THcytosolOne of 2 routes

CHEBI:15971Reach from here →

Catalysed by MTR, SLC7A6cytosol, extracellular spaceOne of 2 routes

L-citrullineReach from here →

Catalysed by MTR, SLC7A6cytosol, extracellular spaceOne of 2 routes

L-valineReach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 3 routes

L-arginineReach from here →

Catalysed by MTR, SLC7A6cytosol, extracellular spaceOne of 5 routes

protein polypeptide chainReach from here →

Catalysed by MTRcytosol

Met-tRNA(Met)Reach from here →

Catalysed by MTR, MARS1cytosol

4-methylsulfanyl-2-oxobutanoateReach from here →

Catalysed by MTR, AADATcytosol

2-oxobutanoateReach from here →

Catalysed by CTHnucleus, cytosol

CHEBI:16857Reach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 3 routes

L-isoleucineReach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 3 routes

CHEBI:17203Reach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 3 routes

AH2Reach from here →

Catalysed by MTR, CDKAL1cytosolOne of 3 routes

L-cysteineReach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 6 routes

CHEBI:17895Reach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 5 routes

CHEBI:18019Reach from here →

Catalysed by MTR, SLC7A6cytosol, extracellular spaceOne of 2 routes

L-glutamineReach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 6 routes

S-methylmercury-L-cysteineReach from here →

Catalysed by MTR, SLC7A8cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

5-hydroxytryptophanReach from here →

Catalysed by TPH1, TPH2cytosolOne of 2 routes

chlorine(.)Reach from here →

Catalysed by MTR, SLC6A14cytosol, extracellular spaceOne of 2 routes

L-aspartateReach from here →

Catalysed by MTR, SLC7A13cytosol, inner side of the membrane, outer side of the membraneOne of 2 routes

4-methylthio-2-oxobutanoic acidReach from here →

Catalysed by MTR, IL4I1cytosol

L-ornithineReach from here →

Catalysed by MTR, SLC7A6cytosol, extracellular spaceOne of 2 routes

glycineReach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 8 routes

7,8-dihydrofolateReach from here →

Catalysed by MTR, DHFR, DHFR2cytosolOne of 4 routes

(6R)-5,10-methenyltetrahydrofolateReach from here →

Catalysed by MTHFD2, MTHFD2Lcytosol, mitochondrial matrixOne of 4 routes

5-formimidoyltetrahydrofolateReach from here →

Catalysed by MTR, FTCDcytosol

L-tryptophanReach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 4 routes

L-alanineReach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 7 routes

L-asparagineReach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 3 routes

L-phenylalanineReach from here →

Catalysed by MTR, SLC7A5cytosol, extracellular spaceOne of 6 routes

L-homocysteineReach from here →

Catalysed by MTR, BHMT2cytosol

S-methyl-L-methionineReach from here →

Catalysed by MTR, BHMT2cytosol

5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamideReach from here →

Catalysed by MTR, ATICcytosol

L-methionine (S)-S-oxideReach from here →

Catalysed by MTR, MSRAcytosol

L-methionine (R)-S-oxideReach from here →

Catalysed by MTR, MSRB3, MSRB1, MSRB2cytosol

dTMPReach from here →

Catalysed by TYMScytosol

, CPT1A

, CPT1C

cytosol, mitochondrial matrix

One of 245 routes

2-hydroxybutyric acidReach from here →

Catalysed by CTH, LDHB, LDHC, LDHAL6A and 1 morenucleus, cytosol