Compound
3-methylbut-2-enoyl-CoA
An unsaturated fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxy group of 3-methylbut-2-enoic acid.
Definition from ChEBI (CHEBI:15486), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
4 entities
4 entities reached.
0 reported hops4 assembled from the scaffold
What the reference databases state
Statements
10 statements
10 statements · 1 reference database · Subject: 3-methylbut-2-enoyl-CoA · Sources: Human-GEM
- 3-methylbut-2-enoyl-CoA is converted to 3-hydroxyisovaleryl-CoACompoundHuman-GEM MAR05999Inferred only
- 3-methylbut-2-enoyl-CoA is converted to 3-methyl-(2E)-glutaconyl-CoACompoundHuman-GEM MAR03773Inferred only
- isovaleryl-CoA is converted to 3-methylbut-2-enoyl-CoACompoundHuman-GEM MAR03770Inferred only
- 3-methylbut-2-enoyl-CoA is converted to isovaleryl-CoACompoundHuman-GEM MAR03770Inferred only
- 3-methylbut-2-enoyl-CoA is a substrate of ACADSBProteinHuman-GEM MAR03770Inferred only
- 3-methylbut-2-enoyl-CoA is a substrate of AUHProteinHuman-GEM MAR05999Inferred only
- 3-methylbut-2-enoyl-CoA is a substrate of GLYATProteinHuman-GEM MAR03772Inferred only
- 3-methylbut-2-enoyl-CoA is a substrate of IVDProteinHuman-GEM MAR03770Inferred only
- 3-methylbut-2-enoyl-CoA is a substrate of MCCC1ProteinHuman-GEM MAR03773Inferred only
- 3-methylbut-2-enoyl-CoA is a substrate of MCCC2ProteinHuman-GEM MAR03773Inferred only
Reactions
8 reactions
3-methylbut-2-enoyl-CoA+FADH2FAD+isovaleryl-CoA
Reaction pageReversibleBalancedEC 1.3.8.4, 1.3.8.5GO:0005759
Human-GEM MAR03770CC BY 4.0Reference data
MAM00825m+CHEBI:1146900+proton3-methylbut-2-enoyl-CoA+glycine
Catalysed by GLYAT
Reaction pageReversibleBalancedEC 2.3.1.13GO:0005759
Human-GEM MAR03772CC BY 4.0Reference data
3-methylbut-2-enoyl-CoA+ATP+hydrogencarbonate3-methyl-(2E)-glutaconyl-CoA+ADP+proton+phosphate(3-)
Reaction pageLeft to rightBalancedEC 6.4.1.4GO:0005759
Human-GEM MAR03773CC BY 4.0Reference data
3-methylbut-2-enoyl-CoA+water3-hydroxyisovaleryl-CoA
Catalysed by AUH
Reaction pageLeft to rightBalancedEC 4.2.1.-GO:0005759
Human-GEM MAR05999CC BY 4.0Reference data
isovaleryl-CoA+oxidized [electron-transfer flavoprotein]+hydron3-methylbut-2-enoyl-CoA+reduced [electron-transfer flavoprotein]
Catalysed by IVD
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:12276CC BY 4.0Reference data
3-methylbut-2-enoyl-CoA+N(6)-carboxybiotinyl-L-lysyl-[protein]3-methyl-(2E)-glutaconyl-CoA+N(6)-biotinyl-L-lysyl-[protein]
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:13025CC BY 4.0Reference data
3-methylbut-2-enoyl-CoA+hydrogencarbonate+ATP(4-)3-methyl-(2E)-glutaconyl-CoA+ADP(3-)+hydrogenphosphate+hydron
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:13589CC BY 4.0Reference data
3-hydroxyisovaleryl-CoA3-methylbut-2-enoyl-CoA+water
Reaction pageRight to leftBalance undeterminable
Rhea RHEA:31079CC BY 4.0Reference data
Other names
12 names
Resolves to: 3-methylbut-2-enoyl-CoA
- Also called
- 3-Methylcrotonoyl-CoA3-Methylcrotonyl-CoA3,3-dimethacrylyl-CoA3,3-dimethacrylyl-coenzyme Abeta,beta-dimethacrylyl-CoAbeta,beta-dimethacrylyl-coenzyme ADimethylacryloyl-CoADMA-CoAS-(3-methylcrotonoyl)-coenzyme-Aβ,β-dimethacrylyl-CoAβ,β-dimethacrylyl-coenzyme A
- Systematic name
- 3'-phosphoadenosine 5'-{3-[(3R)-3-hydroxy-2,2-dimethyl-4-{[3-({2-[(3-methylbut-2-enoyl)sulfanyl]ethyl}amino)-3-oxopropyl]amino}-4-oxobutyl] dihydrogen diphosphate}