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Proteins/UNIPROT:P22102
Trifunctional enzyme that catalyzes three distinct reactions as part of the 'de novo' inosine monophosphate biosynthetic pathway..
Function from UniProtKB (P22102), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
79 statements
79 statements · 6 reference databases · Subject: GART · Sources: Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
6 reactions
5-phospho-beta-D-ribosylamine+ATP+glycineADP+N(1)-(5-phospho-D-ribosyl)glycinamide+proton+phosphate(3-)
Catalysed by GART
Reaction pageLeft to rightBalancedEC 6.3.4.13cytosol
Human-GEM MAR04799CC BY 4.0Reference data
2-formamido-N(1)-(5-phospho-D-ribosyl)acetamidine+ATPADP+MAM01305c
11 names
Resolves to: GART
Catalysed by GART
Reaction pageLeft to rightBalancedEC 6.3.3.1cytosol
Human-GEM MAR04802CC BY 4.0Reference data
10-formyltetrahydrofolic acid+N(1)-(5-phospho-D-ribosyl)glycinamideproton+N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide+5,6,7,8-tetrahydrofolic acid
Catalysed by GART
Reaction pageLeft to rightBalancedEC 2.1.2.2cytosol
Human-GEM MAR04806CC BY 4.0Reference data
N(1)-(5-phospho-beta-D-ribosyl)glycinamide+(6R)-10-formyltetrahydrofolateN(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide+(6S)-5,6,7,8-tetrahydrofolate+hydron
Catalysed by GART
Reaction pageLeft to rightBalanced
Rhea RHEA:15053CC BY 4.0Reference data
5-phospho-beta-D-ribosylamine+glycine+ATP(4-)N(1)-(5-phospho-beta-D-ribosyl)glycinamide+ADP(3-)+hydrogenphosphate+hydron
Catalysed by GART
Reaction pageLeft to rightBalanced
Rhea RHEA:17453CC BY 4.0Reference data
2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine+ATP(4-)5-amino-1-(5-phospho-beta-D-ribosyl)imidazole+ADP(3-)+hydrogenphosphate+hydron
Catalysed by GART
Reaction pageLeft to rightBalanced
Rhea RHEA:23032CC BY 4.0Reference data