Compound
5(S)-HPETE
An icosatetraenoic acid in which the double bonds are located at the 6-7, 8-9, 11-12, and 14-15 positions and have E, Z, Z, and Z geometry, respectively, and in which the pro-S hydrogen is substituted by a hydroperoxy group.
Definition from ChEBI (CHEBI:15632), read 2026-09-23. CC BY 4.0.
What it touches on the way
Mechanistic reach
11 entities
11 entities reached.
0 reported hops11 assembled from the scaffold
- ALOX5ProteinUNIPROT:P09917substrate ofInferred only55 paths55 endpoints
- GPX2ProteinUNIPROT:P18283substrate ofInferred only54 paths27 endpoints
- GPX1ProteinUNIPROT:P07203substrate ofInferred only50 paths25 endpoints
- GPX4ProteinUNIPROT:P36969substrate ofInferred only40 paths20 endpoints
- PRDX6ProteinUNIPROT:P30041substrate ofInferred only30 paths15 endpoints
- GPX3ProteinUNIPROT:P22352substrate ofInferred only26 paths13 endpoints
- GPX6ProteinUNIPROT:P59796substrate ofInferred only16 paths8 endpoints
- GPX7ProteinUNIPROT:Q96SL4substrate ofInferred only14 paths7 endpoints
- GPX5ProteinUNIPROT:O75715substrate ofInferred only12 paths6 endpoints
- GPX8ProteinUNIPROT:Q8TED1substrate ofInferred only8 paths4 endpoints
- FABP1ProteinUNIPROT:P07148transported byInferred only3 paths3 endpoints
What the reference databases state
Statements
22 statements
22 statements · 1 reference database · Subject: 5(S)-HPETE · Sources: Human-GEM
- (5Z,8Z,11Z,14Z)-eicosatetraenoate is converted to 5(S)-HPETECompoundHuman-GEM MAR00958Inferred only
- 5(S)-HPETE is converted to leukotriene A4CompoundHuman-GEM MAR00959Inferred only
- 5(S)-HPETE is a substrate of ALOX5ProteinHuman-GEM MAR00959Inferred only
- 5(S)-HPETE is a substrate of GPX1ProteinHuman-GEM MAR00960Inferred only
- 5(S)-HPETE is a substrate of GPX1ProteinHuman-GEM MAR00963Inferred only
- 5(S)-HPETE is a substrate of GPX2ProteinHuman-GEM MAR00960Inferred only
- 5(S)-HPETE is a substrate of GPX2ProteinHuman-GEM MAR00963Inferred only
- 5(S)-HPETE is a substrate of GPX3ProteinHuman-GEM MAR00963Inferred only
- 5(S)-HPETE is a substrate of GPX3ProteinHuman-GEM MAR00960Inferred only
- 5(S)-HPETE is a substrate of GPX4ProteinHuman-GEM MAR00963Inferred only
- 5(S)-HPETE is a substrate of GPX4ProteinHuman-GEM MAR00960Inferred only
- 5(S)-HPETE is a substrate of GPX5ProteinHuman-GEM MAR00960Inferred only
Show the remaining 10
- 5(S)-HPETE is a substrate of GPX5ProteinHuman-GEM MAR00963Inferred only
- 5(S)-HPETE is a substrate of GPX6ProteinHuman-GEM MAR00963Inferred only
- 5(S)-HPETE is a substrate of GPX6ProteinHuman-GEM MAR00960Inferred only
- 5(S)-HPETE is a substrate of GPX7ProteinHuman-GEM MAR00963Inferred only
- 5(S)-HPETE is a substrate of GPX7ProteinHuman-GEM MAR00960Inferred only
- 5(S)-HPETE is a substrate of GPX8ProteinHuman-GEM MAR00963Inferred only
- 5(S)-HPETE is a substrate of GPX8ProteinHuman-GEM MAR00960Inferred only
- 5(S)-HPETE is a substrate of PRDX6ProteinHuman-GEM MAR00963Inferred only
- 5(S)-HPETE is a substrate of PRDX6ProteinHuman-GEM MAR00960Inferred only
- 5(S)-HPETE is transported by FABP1ProteinHuman-GEM MAR07107Inferred only
Reactions
9 reactions
(5Z,8Z,11Z,14Z)-eicosatetraenoate+dioxygen5(S)-HPETE
Catalysed by ALOX5
Reaction pageLeft to rightBalancedEC 1.13.11.34cytosol
Human-GEM MAR00958CC BY 4.0Reference data
5(S)-HPETEwater+leukotriene A4
Catalysed by ALOX5
Reaction pageLeft to rightBalancedEC 1.13.11.34cytosol
Human-GEM MAR00959CC BY 4.0Reference data
5(S)-HPETE+2CHEBI:168565(S)-HETE+glutathione disulfide+water
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9cytosol
Human-GEM MAR00960CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, mitochondrial matrix
Human-GEM MAR00962CC BY 4.0Reference data
5(S)-HPETE+2CHEBI:168565(S)-HETE+glutathione disulfide+water
Catalysed by GPX7 or PRDX6 or GPX8 or GPX4 or GPX2 or GPX6 or GPX3 or GPX5 or GPX1
Reaction pageLeft to rightBalancedEC 1.11.1.9mitochondrial matrix
Human-GEM MAR00963CC BY 4.0Reference data
Transported by FABP1
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR07107CC BY 4.0Reference data
5(S)-HPETE+ATP+water5(S)-HPETE+ADP+proton+phosphate(3-)
Reaction pageLeft to rightBalancedEC 3.1.1.4cytosol, extracellular space
Human-GEM MAR09986CC BY 4.0Reference data
Reaction pageReversibleBalancedEC 3.1.1.4cytosol, extracellular space
Human-GEM MAR09987CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR10194CC BY 4.0Reference data
Other names
11 names
Resolves to: 5(S)-HPETE
- Also called
- (5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid(5S,6E,8Z,11Z,14Z)-5-Hydroperoxyicosa-6,8,11,14-tetraenoate(6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoate(6E,8Z,11Z,14Z)-(5S)-5-Hydroperoxyeicosa-6,8,11,14-tetraenoic acid(S)-5-HPETE5-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoate5(S)-Hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid5(S)-hydroperoxy-6(E),8(Z),11(Z),14(Z)-eicosatetraenoic acid5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid5S-HpETE
- Systematic name
- (5S,6E,8Z,11Z,14Z)-5-hydroperoxyicosa-6,8,11,14-tetraenoic acid