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nicotinic acid D-ribonucleotide

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

Inferred

Every route here is a hypothesis drawn from reference reactions (Rhea and Human-GEM), not a finding. Currency species such as water, ATP and NAD(H) never form a step. Evidence key

15 compounds within 3 steps: 2 in 1, 3 in 2, 10 in 3

Does it reach a compound?

One step

deamido-NAD(+)Reach from here →
1. Nicotinate-Nucleotide Adenylyltransferase, Mitochondrial
Catalysed by NMNAT3mitochondrial matrixOne of 3 routes
beta-D-ribosylnicotinateReach from here →
1. nicotinate D-ribonucleotide phosphohydrolase
Catalysed by ACP3, NT5E, NT5C, NT5C3B and 4 morecytosol

Two steps

nicotinic acidReach from here →
1. nicotinate D-ribonucleotide phosphohydrolase
2. Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase
Catalysed by ACP3, NT5E, NT5C, NT5C3B and 4 morecytosol
D-ribose 1-phosphateReach from here →
1. nicotinate D-ribonucleotide phosphohydrolase
2. Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase
Catalysed by ACP3, NT5E, NT5C, NT5C3B and 4 morecytosol

Three steps

beta-nicotinamide D-ribosideReach from here →
Catalysed by ACP3, NT5E, NT5C, NT5C3B and 5 morecytosol
adenosineReach from here →

nicotinate beta-D-ribonucleotideReach from here →

Nicotinate-Nucleotide Adenylyltransferase, Mitochondrial
nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate

Catalysed by NMNAT3, NMNAT2, NMNAT1mitochondrial matrixOne of 2 routes

Catalysed by ACP3, NT5E, NT5C, NT5C3B and 5 more

cytosol

uridineReach from here →

nicotinate D-ribonucleotide phosphohydrolase
Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase
uridine:phosphate alpha-D-ribosyltransferase

Catalysed by ACP3, NT5E, NT5C, NT5C3B and 6 morecytosol

guanosineReach from here →

nicotinate D-ribonucleotide phosphohydrolase
Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase
guanosine:phosphate alpha-D-ribosyltransferase

Catalysed by ACP3, NT5E, NT5C, NT5C3B and 5 morecytosol

inosineReach from here →

nicotinate D-ribonucleotide phosphohydrolase
Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase
inosine:phosphate alpha-D-ribosyltransferase

Catalysed by ACP3, NT5E, NT5C, NT5C3B and 5 morecytosol

CHEBI:17797Reach from here →

nicotinate D-ribonucleotide phosphohydrolase
Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase
D-Ribose 1,5-phosphomutase

Catalysed by ACP3, NT5E, NT5C, NT5C3B and 5 morecytosol

xanthosineReach from here →

nicotinate D-ribonucleotide phosphohydrolase
Nicotinate D-ribonucleoside:orthophosphate ribosyltransferase
xanthosine:orthophosphate ribosyltransferase

Catalysed by ACP3, NT5E, NT5C, NT5C3B and 5 morecytosol

quinolinateReach from here →

Nicotinate-Nucleotide Adenylyltransferase, Mitochondrial
nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)

Catalysed by NMNAT3, NMNAT2, NMNAT1, QPRTmitochondrial matrix

nicotinateReach from here →

Nicotinate-Nucleotide Adenylyltransferase, Mitochondrial
nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate

Catalysed by NMNAT3, NMNAT2, NMNAT1, NAPRTmitochondrial matrix

5-phospho-alpha-D-ribose 1-diphosphateReach from here →

Nicotinate-Nucleotide Adenylyltransferase, Mitochondrial
nicotinate beta-D-ribonucleotide + ATP + H(+) = deamido-NAD(+) + diphosphate
nicotinate beta-D-ribonucleotide + CO2 + diphosphate = quinolinate + 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+)

Catalysed by NMNAT3, NMNAT2, NMNAT1, QPRTmitochondrial matrixOne of 2 routes