CHEBI:15345

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

567 compounds within 3 steps: 2 in 1, 111 in 2, 454 in 3

One step

CHEBI:1146900Reach from here →
1. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
Catalysed by HMGCS1cytosolOne of 3 routes
CHEBI:15467Reach from here →
1. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
Catalysed by HMGCS1cytosolOne of 3 routes

Two steps

(S)-carnitineReach from here →
1. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
2. Carnitine O-Palmitoyltransferase
Catalysed by HMGCS1, CPT1A, CPT1C, CPT1BcytosolOne of 244 routes
acetoacetateReach from here →
1. 3-hydroxy-3-methylglutaryl-CoA synthase (acetoacetyl-CoA)
2. hydroxymethylglutaryl-CoA lyase
Catalysed by HMGCS1, HMGCLcytosol, peroxisomeOne of 2 routes

(7Z)-octadecenoyl-CoA

Reach from here →

Catalysed by HMGCS1, CPT1A, CPT1C, CPT1BcytosolOne of 3 routes

cholineReach from here →

Catalysed by HMGCS1, CHATcytosol, nucleus

CHEBI:15380Reach from here →

Catalysed by HMGCS1, ALAS1, CPNE7cytosol, mitochondrial matrixOne of 8 routes

CHEBI:15477Reach from here →

Catalysed by HMGCS1, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 2 routes

2-methylcrotonoyl-CoAReach from here →

Catalysed by HMGCS1, CPT1A, CPT1BcytosolOne of 2 routes

isobutyryl-CoAReach from here →

Catalysed by HMGCS1, HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 3 routes

3-methylbut-2-enoyl-CoAReach from here →

Catalysed by HMGCS1, GLYATcytosol, mitochondrial matrix

isovaleryl-CoAReach from here →

Catalysed by HMGCS1, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 3 routes

arachidonoyl-CoAReach from here →

Catalysed by HMGCS1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 11 routes

CHEBI:15519Reach from here →

Catalysed by HMGCS1, ACAA1, SCP2, MYO5Bcytosol, peroxisomeOne of 2 routes

palmitoyl-CoAReach from here →

Catalysed by HMGCS1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 11 routes

oleoyl-CoAReach from here →

Catalysed by HMGCS1, CPT1A, CPT1C, CPT1BcytosolOne of 11 routes

phenylacetyl-CoAReach from here →

Catalysed by HMGCS1cytosolOne of 3 routes

propionyl-CoAReach from here →

Catalysed by HMGCS1, ACSS3, ACSS2, ACSS1cytosolOne of 43 routes

CHEBI:15650Reach from here →

Catalysed by HMGCS1, ZDHHC11B, NAA10, ESCO2 and 29 morecytosolOne of 2 routes

CHEBI:15727Reach from here →

Catalysed by HMGCS1, NAA10cytosol

CHEBI:15746Reach from here →

Catalysed by HMGCS1, SAT1, SAT2cytosolOne of 2 routes

11-cis-retinolReach from here →

Catalysed by HMGCS1, DGAT1, LRAT, AWAT1 and 2 morecytosol

oxaloacetateReach from here →

Catalysed by HMGCS1, ACLYcytosol

anilineReach from here →

Catalysed by HMGCS1, NAT2, NAT1cytosol

CHEBI:17312Reach from here →

Catalysed by HMGCS1cytosolOne of 2 routes

3-hydroxy-3-methylglutarateReach from here →

Catalysed by HMGCS1cytosol

L-cysteineReach from here →

Catalysed by HMGCS1, NAGScytosol, mitochondrial matrix

(7Z,10Z,13Z)-hexadecatrienoyl-CoAReach from here →

Catalysed by HMGCS1, HADHA, ACADVL, HADHBcytosol, mitochondrial matrix

CHEBI:17927Reach from here →

Catalysed by HMGCS1cytosol

(5Z)-dodecenoyl-CoAReach from here →

Catalysed by HMGCS1, HADHA, ACAA2, HADHBcytosol, mitochondrial matrixOne of 2 routes

(11Z)-docosenoyl-CoA(4-)Reach from here →

Catalysed by HMGCS1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes

(7Z)-tetradecenoyl-CoAReach from here →

Catalysed by HMGCS1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 8 routes

(4Z,7Z,10Z,13Z)-hexadecatetraenoyl-CoAReach from here →

Catalysed by HMGCS1, HADHA, ACADVL, HADHBcytosol, mitochondrial matrixOne of 3 routes

(7Z,10Z)-hexadecadienoyl-CoAReach from here →

Catalysed by HMGCS1, HADHA, ACADVL, HADHBcytosol, mitochondrial matrix

(4Z,7Z)-decadienoyl-CoAReach from here →

Catalysed by HMGCS1, ECHS1, ACAA2, HADHcytosol, mitochondrial matrixOne of 2 routes

(5Z)-octenoyl-CoAReach from here →

Catalysed by HMGCS1, ECHS1, ACAA2, HADHcytosol, mitochondrial matrixOne of 2 routes

CHEBI:27540Reach from here →

Catalysed by HMGCS1, ACSM4, ACSM1, ACSM2A and 3 morecytosolOne of 6 routes

elaidic acidReach from here →

Catalysed by HMGCS1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 5 routes

CHEBI:28701Reach from here →

Catalysed by HMGCS1, ACAA1, SCP2, MYO5Bcytosol, peroxisomeOne of 7 routes

taurineReach from here →

Catalysed by HMGCS1, BAATcytosolOne of 2 routes

glycineReach from here →

Catalysed by HMGCS1, GLYAT, GLYATL2, GLYATL1cytosol, mitochondrial matrixOne of 10 routes

(R)-methylmalonyl-CoAReach from here →

Catalysed by HMGCS1, ALDH6A1cytosol, mitochondrial matrixOne of 2 routes

(S)-methylmalonyl-CoAReach from here →

Catalysed by HMGCS1cytosol, mitochondrial matrix

3'-dephospho-CoAReach from here →

Catalysed by HMGCS1, ACP2cytosol, lysosomeOne of 2 routes

(2E)-dodecenoyl-CoAReach from here →

Catalysed by HMGCS1cytosol, mitochondrial matrixOne of 3 routes

3-methyl-(2E)-glutaconyl-CoAReach from here →

Catalysed by HMGCS1, AUHcytosol, mitochondrial matrix

4,8,12-trimethyltridecanoyl-CoAReach from here →

Catalysed by HMGCS1, ACAA1, MYO5Bcytosol, peroxisomeOne of 2 routes

(6Z,9Z,12Z)-octadecatrienoyl-CoAReach from here →

Catalysed by HMGCS1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 7 routes

butanoyl-CoAReach from here →

Catalysed by HMGCS1, ACSM4, ACSM1, ACSM2A and 3 morecytosolOne of 9 routes

dodecanoyl-CoAReach from here →

Catalysed by HMGCS1, SLC27A2, ACSL4, ACSL3 and 5 morecytosolOne of 9 routes