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Proteins/UNIPROT:P41250
Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis..
Function from UniProtKB (P41250), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
4 rows
179 statements
179 statements · 7 reference databases · Subject: GARS1 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways
3 reactions
ATP+glycine+MAM03070cAMP+Gly-tRNA(Gly)+diphosphate(3-)
Catalysed by GARS1
Reaction pageLeft to rightBalance undeterminableEC 6.1.1.14cytosol
Human-GEM MAR05138CC BY 4.0Reference data
CHEBI:78442+glycine+ATP(4-)CHEBI:78522+AMP+diphosphate(3-)
Catalysed by
6 names
Resolves to: GARS1
Reaction pageLeft to rightBalanced
Rhea RHEA:16013CC BY 4.0Reference data
2ATP(4-)+hydronP(1),P(4)-bis(5'-adenosyl) tetraphosphate+diphosphate(3-)
Catalysed by GARS1
Reaction pageLeft to rightBalanced
Rhea RHEA:34935CC BY 4.0Reference data