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Proteins/UNIPROT:Q4U2R8
Secondary active transporter that functions as a Na(+)-independent organic anion (OA)/dicarboxylate antiporter where the uptake of one molecule of OA into the cell is coupled with an efflux of one molecule of intracellular dicarboxylate such as 2-oxoglutarate or glutarate. Mediates the uptake of OA across the basolateral side of proximal tubule epithelial cells, thereby contributing to the renal elimination of endogenous OA from the systemic circulation into the urine. Functions as a biopterin transporters involved in the uptake and the secretion of coenzymes tetrahydrobiopterin (BH4), dihydrobiopterin (BH2) and sepiapterin to urine, thereby determining baseline levels of blood biopterins. Transports prostaglandin E2 (PGE2) and prostaglandin F2-alpha (PGF2-alpha) and may contribute to their renal excretion. Also mediates the uptake of cyclic nucleotides such as cAMP and cGMP. Involved in the transport of neuroactive tryptophan metabolites kynurenate (KYNA) and xanthurenate (XA) and may contribute to their secretion from the brain. May transport glutamate. Also involved in the disposition of uremic toxins and potentially toxic xenobiotics by the renal organic anion secretory pathway, helping reduce their undesired toxicological effects on the body. Uremic toxins include the indoxyl sulfate (IS), hippurate/N-benzoylglycine (HA), indole acetate (IA), 3-carboxy-4- methyl-5-propyl-2-furanpropionate (CMPF) and urate. Xenobiotics include the mycotoxin ochratoxin (OTA). May also contribute to the transport of organic compounds in testes across the blood-testis-barrier..
Function from UniProtKB (Q4U2R8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
51 statements
51 statements · 5 reference databases · Subject: SLC22A6 · Sources: Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
23 reactions
kynurenate+2-oxoglutarate(2-)kynurenate+2-oxoglutarate(2-)
Transported by SLC22A8 or SLC22A6
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09576CC BY 4.0Reference data
2-oxoglutarate(2-)+MAM01571e2-oxoglutarate(2-)+MAM01571c
8 names
Resolves to: SLC22A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR09588CC BY 4.0Reference data
quinolinic acid+sulfatequinolinic acid+sulfate
Transported by SLC22A6
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR09819CC BY 4.0Reference data
2-oxoglutarate(2-)+folic acid+sodium(1+)2-oxoglutarate(2-)+folic acid+sodium(1+)
Transported by SLC22A6
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR09883CC BY 4.0Reference data
2-oxoglutarate(2-)+indoxyl sulfate2-oxoglutarate(2-)+indoxyl sulfate
Transported by SLC22A6
Reaction pageLeft to rightBalancedcytosol, extracellular space
Human-GEM MAR10464CC BY 4.0Reference data
MAM01110e+2-oxoglutarate(2-)MAM01110c+2-oxoglutarate(2-)
Transported by SLC22A8 or SLC22A6
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR11811CC BY 4.0Reference data
3,4-dihydroxyphenylacetate3,4-dihydroxyphenylacetate
Transported by SLC22A8 or SLC22A6
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR11812CC BY 4.0Reference data
MAM00727cMAM00727e
Transported by SLC22A8 or SLC22A6
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR11813CC BY 4.0Reference data
MAM01113cMAM01113e
Transported by SLC22A8 or SLC22A6
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR11814CC BY 4.0Reference data
2-oxoglutarate(2-)+sodium(1+)+MAM04000e2-oxoglutarate(2-)+sodium(1+)+MAM04000c
Transported by SLC22A6
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR12867CC BY 4.0Reference data
(indol-3-yl)acetate+a dicarboxylate(indol-3-yl)acetate+a dicarboxylate
Transported by SLC22A6 or SLC22A8
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:75983CC BY 4.0Reference data
indoxyl sulfate+a dicarboxylateindoxyl sulfate+a dicarboxylate
Transported by SLC22A6 or SLC22A8
Reaction pageDirection not assertedBalance undeterminable
Rhea RHEA:75987CC BY 4.0Reference data