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Proteins/UNIPROT:Q6GTS8
Secreted enzyme that regulates the endogenous N-fatty acyl amino acid (NAAs) tissue and circulating levels by functioning as a bidirectional NAA synthase/hydrolase. It condenses free fatty acids and free amino acids to generate NAAs and bidirectionally catalyzes the reverse hydrolysis reaction. Some of these NAAs stimulate oxidative metabolism via mitochondrial uncoupling, increasing energy expenditure in a UPC1-independent manner. Thereby, this secreted protein may indirectly regulate whole body energy expenditure. PM20D1 circulates in tight association with both low- and high-density (LDL and HDL,respectively) lipoprotein particles (By similarity)..
Function from UniProtKB (Q6GTS8), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 2 · substrate of
2 compounds
2 compounds.
0 reported routes2 assembled routes
38 statements
38 statements · 4 reference databases · Subject: PM20D1 · Sources: Bgee, Reactome, Rhea, UniProt
18 reactions
an N-acyl-L-amino acid+wateran L-alpha-amino acid+a carboxylate
Reaction pageReversibleBalance undeterminable
Rhea RHEA:15565CC BY 4.0Reference data
L-phenylalanine+(9Z)-octadecenoateN-(9Z-octadecenoyl)-L-phenylalanine+water
Catalysed by PM20D1
Reaction pageReversibleBalanced
1 name
Resolves to: PM20D1
(5Z,8Z,11Z,14Z)-eicosatetraenoate+L-phenylalanineN-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-phenylalanine+water
Catalysed by PM20D1
Reaction pageReversibleBalanced
Rhea RHEA:51312CC BY 4.0Reference data
(9Z)-octadecenoate+glycineN-(9Z-octadecenoyl)glycine+water
Reaction pageRight to leftBalanced
Rhea RHEA:51316CC BY 4.0Reference data
N-(9Z-octadecenoyl)-L-serine+waterL-seryl residue+(9Z)-octadecenoate
Catalysed by PM20D1
Reaction pageLeft to rightBalanced
Rhea RHEA:51352CC BY 4.0Reference data
N-(9Z-octadecenoyl)-L-glutamine+waterL-glutamine+(9Z)-octadecenoate
Catalysed by PM20D1
Reaction pageLeft to rightBalanced
Rhea RHEA:51356CC BY 4.0Reference data
N-(9Z-octadecenoyl)-L-leucine+waterL-leucine+(9Z)-octadecenoate
Catalysed by PM20D1
Reaction pageReversibleBalanced
Rhea RHEA:51360CC BY 4.0Reference data
an N-acyl-aromatic L-alpha-amino acid+wateran aromatic L-alpha-amino acid+a carboxylate
Reaction pageReversibleBalance undeterminable
Rhea RHEA:54184CC BY 4.0Reference data
N-(5Z,8Z,11Z,14Z)-eicosatetraenoyl-glycine+water(5Z,8Z,11Z,14Z)-eicosatetraenoate+glycine
Reaction pageReversibleBalanced
Rhea RHEA:64108CC BY 4.0Reference data
N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-L-serine+water(5Z,8Z,11Z,14Z)-eicosatetraenoate+L-seryl residue
Reaction pageReversibleBalanced
Rhea RHEA:64116CC BY 4.0Reference data
N-hexadecanoyl-L-phenylalanine+waterhexadecanoate+L-phenylalanine
Catalysed by PM20D1
Reaction pageLeft to rightBalanced
Rhea RHEA:64124CC BY 4.0Reference data
N-octadecanoyl-L-phenylalanine+wateroctadecanoate+L-phenylalanine
Catalysed by PM20D1
Reaction pageLeft to rightBalanced
Rhea RHEA:64128CC BY 4.0Reference data