Loading the page.
Proteins/UNIPROT:P50135
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine..
Function from UniProtKB (P50135), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
2 rows
68 statements
68 statements · 6 reference databases · Subject: HNMT · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
4 reactions
S-adenosyl-L-methionine+5,6,7,8-tetrahydrofolic acid5-methyltetrahydrofolic acid+CHEBI:16680
Catalysed by HNMT
Reaction pageLeft to rightBalancedEC 2.1.1.8cytosol
Human-GEM MAR03915CC BY 4.0Reference data
histamine+S-adenosyl-L-methionineproton+N(tau)-methylhistamine+CHEBI:16680
Catalysed by HNMT
1 name
Resolves to: HNMT
Human-GEM MAR04429CC BY 4.0Reference data
histamine+S-adenosyl-L-methionineproton+N(tau)-methylhistamine+CHEBI:16680
Catalysed by HNMT
Reaction pageLeft to rightBalancedextracellular space
Human-GEM MAR11777CC BY 4.0Reference data
histamine+S-adenosyl-L-methionineN(tau)-methylhistamine+S-adenosyl-L-homocysteine+hydron
Catalysed by HNMT
Reaction pageDirection not assertedBalanced
Rhea RHEA:19301CC BY 4.0Reference data