5(S)-HPETE

362,296 routes · scope human · up to 3 steps · built 5 October 2026 · Reactions · API

111 compounds within 3 steps: 3 in 1, 8 in 2, 100 in 3

One step

5(S)-HETEReach from here →
1. Glutathione: 5-HPETE oxidoreductase
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 2 routes
leukotriene A4Reach from here →
1. arachidonate:oxygen 5-oxidoreductase
Catalysed by ALOX5cytosol
glutathione disulfideReach from here →
1. Glutathione: 5-HPETE oxidoreductase
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 2 routes

Two steps

2,4-dinitrophenyl-S-glutathioneReach from here →
1. arachidonate:oxygen 5-oxidoreductase
2. transport of leukotriene A4 (cytosol to extracellular)
Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 2 routes
15(S)-HPETEReach from here →
1. Glutathione: 5-HPETE oxidoreductase
2. Glutathione: 15-HPETE oxidoreductase
Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol

Three steps

L-cystine

Reach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosol

CHEBI:16856Reach from here →

Catalysed by ALOX5, SLCO2A1cytosol, extracellular spaceOne of 9 routes

methylarsonateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

thiosulfateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosolOne of 4 routes

leukotriene C4Reach from here →

Catalysed by ALOX5, LTC4ScytosolOne of 3 routes

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

tauroursodeoxycholateReach from here →

Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 5 routes

glycoursodeoxycholateReach from here →

Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 5 routes

(15S)-hydroxy-(5Z,8Z,11Z,13E,17Z)-eicosapentaenoateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 5 morecytosolOne of 2 routes

(11S,15S)-dihydroxy-14(R)-S-glutathionyl-(5Z,8Z,12E)-eicosatrienoateReach from here →

Catalysed by ALOX5, SLCO2A1, PTGES, MGST3 and 19 morecytosol, extracellular spaceOne of 5 routes

prostaglandin E3Reach from here →

Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 4 routes

prostaglandin A2Reach from here →

Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 4 routes

prostaglandin B1Reach from here →

Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 4 routes

leukotriene F4Reach from here →

Catalysed by ALOX5, LTC4ScytosolOne of 6 routes

prostaglandin A2-S-(R)-glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol

prostaglandin A2-S-(S)-glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol

prostaglandin J2-S-(R)-glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 9 morecytosol

prostaglandin J2-S-(S)-glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol

(13R)-S-glutathionyl-(14S)-hydroxy-(4Z,7Z,9E,11E,16Z,19Z)-docosahexaenoateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol

S-methyl glutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

L-cystine-bis-glycineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

S-adenosylglutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol

acetylcholineReach from here →

Catalysed by ALOX5, SLCO1B1, SLCO1B3cytosol, extracellular spaceOne of 4 routes

pyruvateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol

(S)-malateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, mitochondrial matrixOne of 2 routes

L-leucineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, extracellular space

CHEBI:15650Reach from here →

Catalysed by ALOX5, SLCO1B1cytosol, extracellular spaceOne of 4 routes

bromideReach from here →

Catalysed by ALOX5, SLCO2A1, MGST3, GSTA4 and 15 morecytosol, extracellular spaceOne of 2 routes

a halide anionReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 29 morecytosol

sulfateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosolOne of 3 routes

lithocholic acidReach from here →

Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

L-arginineReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 6 morecytosol, inner side of the membrane, outer side of the membrane

bilirubin IXalphaReach from here →

Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

taurolithocholateReach from here →

Catalysed by ALOX5, SLCO1B1, SLCO1A2, SLCO1B3cytosol, extracellular spaceOne of 4 routes

CHEBI:17208Reach from here →

Catalysed by ALOX5, SLCO2A1cytosol, extracellular space

homocysteineReach from here →

Catalysed by ALOX5, SLCO2A1cytosol, extracellular space

sulfiteReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosolOne of 6 routes

L-cysteineReach from here →

Catalysed by ALOX5, SLCO2A1cytosol, extracellular spaceOne of 4 routes

urateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, inner side of the membrane, outer side of the membrane

methylarsonous acidReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosolOne of 2 routes

fumaric acidReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosol, mitochondrial matrixOne of 2 routes

thiocyanateReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 8 morecytosol, mitochondrial matrixOne of 2 routes

arsenic triglutathioneReach from here →

Catalysed by GPX5, GPX1, GPX2, GPX3 and 7 morecytosolOne of 3 routes