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Proteins/UNIPROT:P22307
[Isoform SCPx]: Plays a crucial role in the peroxisomal oxidation of branched-chain fatty acids. Catalyzes the last step of the peroxisomal beta-oxidation of branched chain fatty acids and the side chain of the bile acid intermediates di- and trihydroxycoprostanic acids (DHCA and THCA). Also active with medium and long straight chain 3-oxoacyl-CoAs. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol and transfers phosphatidylcholine and 7-dehydrocholesterol between membrances, in vitro (By similarity). Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity)..
[Isoform SCP2]: Mediates the transfer of all common phospholipids, cholesterol and gangliosides from the endoplasmic reticulum to the plasma membrane. May play a role in regulating steroidogenesis. Stimulates the microsomal conversion of 7-dehydrocholesterol to cholesterol (By similarity). Also binds fatty acids and fatty acyl Coenzyme A (CoA) such as phytanoyl-CoA. Involved in the regulation phospholipid synthesis in endoplasmic reticulum enhancing the incorporation of exogenous fatty acid into glycerides. Seems to stimulate the rate-limiting step in phosphatidic acid formation mediated by GPAT3. Isoforms SCP2 and SCPx cooperate in peroxisomal oxidation of certain naturally occurring tetramethyl-branched fatty acyl-CoAs (By similarity)..
Function from UniProtKB (P22307), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
1 row
379 statements
379 statements · 8 reference databases · Subject: SCP2 · Sources: Bgee, gene ontology, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, WikiPathways · Rows fetched: 300
23 reactions
3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA+CHEBI:1146900CHEBI:15519+propionyl-CoA
Catalysed by ACAA1 or SCP2 or MYO5B
Reaction pageLeft to rightBalancedEC 2.3.1.176, 2.3.1.16peroxisome
Human-GEM MAR01652CC BY 4.0Reference data
MAM00754x+CHEBI:1146900CHEBI:28701+propionyl-CoA
Catalysed by ACAA1 or
11 names
Resolves to: SCP2
Reaction pageLeft to rightBalancedEC 2.3.1.176peroxisome
Human-GEM MAR01710CC BY 4.0Reference data
7MAM00755x+3carbon dioxide+8CHEBI:1146900+2water8propionyl-CoA+7MAM03548x
Catalysed by SCP2
Reaction pageLeft to rightBalancedEC 2.7.7.4peroxisome
Human-GEM MAR01711CC BY 4.0Reference data
MAM00614m+CHEBI:1146900+dioxygenCHEBI:28701+water+propionyl-CoA
Catalysed by SCP2
Reaction pageReversibleBalancedEC 2.3.1.176mitochondrial matrix
Human-GEM MAR02950CC BY 4.0Reference data
MAM00614x+CHEBI:1146900+dioxygenCHEBI:28701+water+propionyl-CoA
Catalysed by SCP2
Reaction pageLeft to rightBalancedEC 2.3.1.176peroxisome
Human-GEM MAR02953CC BY 4.0Reference data
3-oxodecanoyl-CoA+CHEBI:1146900CHEBI:15351+octanoyl-CoA
Reaction pageLeft to rightBalancedEC 2.3.1.16peroxisome
Human-GEM MAR03093CC BY 4.0Reference data
MAM00854x+CHEBI:1146900CHEBI:15351+MAM01575x
Reaction pageLeft to rightBalancedEC 2.3.1.16peroxisome
Human-GEM MAR03315CC BY 4.0Reference data
MAM00933cMAM00933x
Transported by SCP2
Reaction pageReversibleBalancedEC 1.5.1.10cytosol, peroxisome
Human-GEM MAR03517CC BY 4.0Reference data
CHEBI:1146900+FAD+water+NAD(+)+hexanedioyl-CoACHEBI:15351+FADH2+proton+NADH(2-)+CHEBI:15380
Catalysed by ACAA1 & EHHADH & ACOX1 or SCP2 & EHHADH & ACOX1 or ACAA1 & HSD17B4 & ACOX1 or SCP2 & HSD17B4 & ACOX1 or ACOX3 & ACAA1 & EHHADH or ACOX3 & SCP2 & EHHADH or ACOX3 & ACAA1 & HSD17B4 or ACOX3 & SCP2 & HSD17B4
Reaction pageLeft to rightBalancedperoxisome
Human-GEM MAR06285CC BY 4.0Reference data
4,8,12-trimethyltridecanoyl-CoA+propanoyl-CoA3-oxopristanoyl-CoA+coenzyme A(4-)
Catalysed by SCP2
Reaction pageRight to leftBalanced
Rhea RHEA:10408CC BY 4.0Reference data
choloyl-CoA+propanoyl-CoA3alpha,7alpha,12alpha-trihydroxy-24-oxo-5beta-cholestan-26-oyl-CoA+coenzyme A(4-)
Catalysed by SCP2
Reaction pageRight to leftBalanced
Rhea RHEA:16865CC BY 4.0Reference data
tetradecanoyl-CoA+acetyl-CoA3-oxohexadecanoyl-CoA+coenzyme A(4-)
Catalysed by ACAA1 or SCP2 or HADHB
Reaction pageRight to leftBalanced
Rhea RHEA:18161CC BY 4.0Reference data