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Proteins/UNIPROT:Q6YP21
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA), an intermediate in the tryptophan catabolic pathway which is also a broad spectrum antagonist of the three ionotropic excitatory amino acid receptors among others. May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro)..
Function from UniProtKB (Q6YP21), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
79 statements
79 statements · 8 reference databases · Subject: KYAT3 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
9 reactions
2-oxoglutarate(2-)+L-kynureninekynurenate+L-glutamate(1-)+water
Reaction pageLeft to rightBalancedEC 2.6.1.7mitochondrial matrix
Human-GEM MAR02765CC BY 4.0Reference data
L-glutamine+pyruvate2-oxoglutaramate+L-alanine
Catalysed by AADAT or
8 names
Resolves to: KYAT3
Reaction pageLeft to rightBalancedEC 2.6.1.15, 2.6.1.63mitochondrial matrix
Human-GEM MAR04197CC BY 4.0Reference data
2-oxoglutarate(2-)+L-kynureninekynurenate+L-glutamate(1-)+water
Reaction pageLeft to rightBalancedEC 2.6.1.7cytosol
Human-GEM MAR04222CC BY 4.0Reference data
CHEBI:17380+2-oxoglutarate(2-)4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoate+L-glutamate(1-)
Catalysed by AADAT or KYAT3 or KYAT1
Reaction pageLeft to rightBalancedEC 2.6.1.7cytosol
Human-GEM MAR04244CC BY 4.0Reference data
CHEBI:17380+2-oxoglutarate(2-)L-glutamate(1-)+water+xanthurenate
Catalysed by AADAT or KYAT3 or KYAT1
Reaction pageReversibleBalancedEC 2.6.1.7cytosol
Human-GEM MAR04246CC BY 4.0Reference data
an S-substituted L-cysteine+watera thiol+pyruvate+ammonium
Reaction pageLeft to rightBalance undeterminable
Rhea RHEA:18121CC BY 4.0Reference data
L-kynurenine+2-oxoglutarate(2-)kynurenate+L-glutamate(1-)+water
Catalysed by GOT2 or KYAT1 or KYAT3 or AADAT
Reaction pageLeft to rightBalanced
Rhea RHEA:65560CC BY 4.0Reference data
L-kynurenine+glyoxylatekynurenate+glycine+water
Reaction pageLeft to rightBalanced
Rhea RHEA:65896CC BY 4.0Reference data
3-hydroxy-L-kynurenine+glyoxylatexanthurenate+glycine+water
Reaction pageLeft to rightBalanced
Rhea RHEA:65900CC BY 4.0Reference data