Compound
androsterone
A metabolite of testosterone or androstenedione with a 3-alpha-hydroxyl group and without the double bond. The 3-beta hydroxyl isomer is epiandrosterone.
Structure
Loading the model…
- Class
- Organic compound
- Formula
- C19H30O2
- Mass
- 290.447 g/mol
- Charge
- 0
- InChIKey
- QGXBDMJGAMFCBF-HLUDHZFRSA-N
- SMILES
- [H][C@@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)C(=O)CC[C@@]34[H])[C@@]1(C)CC[C@@H](O)C2
- Look it up
- ChEBIPubChemBy InChIKey
Identity from ChEBI, geometry from PubChem. Not evidence.
What it touches on the way
Mechanistic reach
19 entities
19 entities reached.
0 reported hops19 assembled from the scaffold
- AKR1C3ProteinUNIPROT:P42330substrate ofInferred only70 paths35 endpoints
- AKR1C1ProteinUNIPROT:Q04828substrate ofInferred only50 paths25 endpoints
- STSProteinUNIPROT:P08842substrate ofInferred only42 paths14 endpoints
- UGT1A1ProteinUNIPROT:P22309metabolized byInferred only25 paths25 endpoints
- SULT2A1ProteinUNIPROT:Q06520metabolized byInferred only24 paths24 endpoints
- AKR1C4ProteinUNIPROT:P17516substrate ofInferred only21 paths21 endpoints
- HSD17B3ProteinUNIPROT:P37058substrate ofInferred only17 paths17 endpoints
- HSD17B7ProteinUNIPROT:P56937substrate ofInferred only17 paths17 endpoints
- RDH5ProteinUNIPROT:Q92781substrate ofInferred only16 paths16 endpoints
- UGT2B7ProteinUNIPROT:P16662metabolized byInferred only16 paths16 endpoints
- AKR1C2ProteinUNIPROT:P52895substrate ofInferred only16 paths16 endpoints
- UGT1A10ProteinUNIPROT:Q9HAW8metabolized byInferred only14 paths14 endpoints
Show the remaining 7
- UGT1A8ProteinUNIPROT:Q9HAW9metabolized byInferred only11 paths11 endpoints
- DHRS9ProteinUNIPROT:Q9BPW9substrate ofInferred only9 paths9 endpoints
- UGT2B17ProteinUNIPROT:O75795metabolized byInferred only9 paths9 endpoints
- UGT2B28ProteinUNIPROT:Q9BY64metabolized byInferred only8 paths8 endpoints
- RDH16ProteinUNIPROT:O75452substrate ofInferred only7 paths7 endpoints
- AKR1B15ProteinUNIPROT:C9JRZ8substrate ofInferred only5 paths5 endpoints
- HSD17B6ProteinUNIPROT:O14756substrate ofInferred only4 paths4 endpoints
What the reference databases state
Statements
35 statements
35 statements · 2 reference databases · Subject: androsterone · Sources: Human-GEM, Rhea
- androsterone is converted to 3beta,16alpha-dihydroxy-androst-5-en-17-oneCompoundHuman-GEM MAR07970Inferred only
- 5alpha-androstan-3,17-dione is converted to androsteroneCompoundHuman-GEM MAR02018Inferred only
- 5alpha-androstan-3,17-dione is converted to androsteroneCompoundRhea RHEA:20377Inferred only
- 5alpha-androstan-3,17-dione is converted to androsteroneCompoundRhea RHEA:20381Inferred only
- androsterone is converted to 5alpha-androstan-3,17-dioneCompoundRhea RHEA:20381Inferred only
- 5alpha-androstan-3,17-dione is converted to androsteroneCompoundHuman-GEM MAR02016Inferred only
- 5alpha-androstan-3,17-dione is converted to androsteroneCompoundHuman-GEM MAR02017Inferred only
- 5alpha-androstan-3,17-dione is converted to androsteroneCompoundHuman-GEM MAR02019Inferred only
- 5alpha-androstane-3alpha,17beta-diol is converted to androsteroneCompoundRhea RHEA:42124Inferred only
- androsterone is converted to 5alpha-androstane-3alpha,17beta-diolCompoundRhea RHEA:42124Inferred only
- androsterone is converted to 5alpha-androstane-3alpha,17beta-diolCompoundRhea RHEA:42156Inferred only
- androsterone is converted to androsterone 3alpha-sulfateCompoundRhea RHEA:60644Inferred only
Show the remaining 23
- androsterone is metabolised by SULT2A1ProteinRhea RHEA:60644Inferred only
- androsterone is metabolised by UGT1A1ProteinHuman-GEM MAR07965Inferred only
- androsterone is metabolised by UGT1A10ProteinHuman-GEM MAR07965Inferred only
- androsterone is metabolised by UGT1A8ProteinHuman-GEM MAR07965Inferred only
- androsterone is metabolised by UGT2B17ProteinHuman-GEM MAR07965Inferred only
- androsterone is metabolised by UGT2B28ProteinHuman-GEM MAR07965Inferred only
- androsterone is metabolised by UGT2B7ProteinHuman-GEM MAR07965Inferred only
- androsterone is a substrate of AKR1B15ProteinRhea RHEA:42156Inferred only
- androsterone is a substrate of AKR1C1ProteinRhea RHEA:42156Inferred only
- androsterone is a substrate of AKR1C1ProteinRhea RHEA:42124Inferred only
- androsterone is a substrate of AKR1C2ProteinRhea RHEA:42124Inferred only
- androsterone is a substrate of AKR1C3ProteinRhea RHEA:42156Inferred only
- androsterone is a substrate of AKR1C3ProteinRhea RHEA:42124Inferred only
- androsterone is a substrate of AKR1C4ProteinRhea RHEA:42124Inferred only
- androsterone is a substrate of DHRS9ProteinRhea RHEA:20381Inferred only
- androsterone is a substrate of HSD17B3ProteinRhea RHEA:42156Inferred only
- androsterone is a substrate of HSD17B6ProteinRhea RHEA:20381Inferred only
- androsterone is a substrate of HSD17B7ProteinHuman-GEM MAR07970Inferred only
- androsterone is a substrate of RDH16ProteinRhea RHEA:20381Inferred only
- androsterone is a substrate of RDH5ProteinRhea RHEA:20381Inferred only
- androsterone is a substrate of STSProteinHuman-GEM MAR02020Inferred only
- androsterone is a substrate of STSProteinHuman-GEM MAR03602Inferred only
- androsterone is a substrate of STSProteinHuman-GEM MAR03603Inferred only
Reactions
18 reactions
5alpha-androstan-3,17-dione+proton+NADH(2-)androsterone+NAD(+)
Catalysed by AKR1C2 or AKR1C1 or AKR1C3 or AKR1C4
Reaction pageLeft to rightBalancedEC 1.1.1.209, 1.1.1.213, 1.1.1.50cytosol
Human-GEM MAR02016CC BY 4.0Reference data
5alpha-androstan-3,17-dione+proton+NADH(2-)androsterone+NAD(+)
Catalysed by AKR1C2 or AKR1C1 or AKR1C3 or AKR1C4
Reaction pageLeft to rightBalancedEC 1.1.1.209, 1.1.1.213, 1.1.1.50endoplasmic reticulum
Human-GEM MAR02017CC BY 4.0Reference data
5alpha-androstan-3,17-dione+proton+NADPH(4-)androsterone+NADP(3-)
Catalysed by AKR1C2 or AKR1C1 or AKR1C3 or AKR1C4
Reaction pageLeft to rightBalancedEC 1.1.1.209, 1.1.1.213, 1.1.1.50cytosol
Human-GEM MAR02018CC BY 4.0Reference data
5alpha-androstan-3,17-dione+proton+NADPH(4-)androsterone+NADP(3-)
Catalysed by AKR1C2 or AKR1C1 or AKR1C3 or AKR1C4
Reaction pageLeft to rightBalancedEC 1.1.1.209, 1.1.1.213, 1.1.1.50endoplasmic reticulum
Human-GEM MAR02019CC BY 4.0Reference data
androsterone 3alpha-sulfate+waterandrosterone+proton+sulfate
Catalysed by STS
Reaction pageReversibleBalancedEC 3.1.6.2cytosol
Human-GEM MAR02020CC BY 4.0Reference data
androsterone+proton+sulfateandrosterone 3alpha-sulfate+water
Catalysed by STS
Reaction pageReversibleBalancedEC 3.1.6.2lysosome
Human-GEM MAR03602CC BY 4.0Reference data
androsterone+proton+sulfateandrosterone 3alpha-sulfate+water
Catalysed by STS
Reaction pageReversibleBalancedEC 3.1.6.2endoplasmic reticulum
Human-GEM MAR03603CC BY 4.0Reference data
androsterone+UDP-alpha-D-glucuronateMAM01339r+UDP
Catalysed by UGT2B28 or UGT2B7 or UGT2B17 or UGT1A1 or UGT1A8 or UGT1A10
Reaction pageLeft to rightBalancedEC 2.4.1.17endoplasmic reticulum
Human-GEM MAR07965CC BY 4.0Reference data
androsterone+proton+NADPH(4-)+1.5dioxygen3beta,16alpha-dihydroxy-androst-5-en-17-one+2water+NADP(3-)
Catalysed by HSD17B7
Reaction pageLeft to rightBalancedEC 1.1.1.270endoplasmic reticulum
Human-GEM MAR07970CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR08593CC BY 4.0Reference data
Reaction pageReversibleBalancedcytosol, endoplasmic reticulum
Human-GEM MAR08594CC BY 4.0Reference data
Reaction pageReversibleBalance undeterminableextracellular space
Human-GEM MAR09263CC BY 4.0Reference data
On the label
Labelled products
15 products
Source: NIH DSLD · Ingredient: androsterone · 15 products · Declared amount per serving: 50–150 mg (4 products)
4 labels state an amount11 do not
- Alchemy LabsNotoriousamount not statedper 2 Capsule(s)DSLD:242000
- Alchemy LabsNotoriousamount not statedper 2 Capsule(s)DSLD:242000
- Alchemy LabsNotoriousamount not statedper 2 Capsule(s)DSLD:242000
- Alchemy LabsPeeledamount not statedper 2 Capsule(s)DSLD:242008
- Alchemy LabsPeeledamount not statedper 2 Capsule(s)DSLD:242008
- Alchemy LabsShredded3amount not statedper 2 Capsule(s)DSLD:242025
- Alchemy LabsTri-Ad Massamount not statedper 2 Capsule(s)DSLD:242031
- Alchemy LabsTri-Ad Massamount not statedper 2 Capsule(s)DSLD:242031
- Blackstone LabsMetha-Quad Extreme150 mgper 1 Tablet(s)DSLD:180666
- Blackstone LabsMetha-Quad Extreme150 mgper 1 Tablet(s)DSLD:204774
- Gaspari NutritionHalodrolamount not statedper 1 Tablet(s)DSLD:80236
- Gaspari NutritionNova-XAndrosterone Note: a natural metabolite of DHEA50 mgper 1 Tablet(s)DSLD:80438
Show the remaining 3
- Hi-Tech PharmaceuticalsDianabol 575 mgamount not statedper 1 Tablet(s)DSLD:246716
- HTP Hi-Tech PharmaceuticalsHalodrolamount not statedper 1 Tablet(s)DSLD:239453
- IML IronMag LabsSuper R Andro Rx100 mgper 1 Capsule(s)DSLD:69937
Label record: NIH Office of Dietary Supplements · CC0
Other names
15 names
Resolves to: androsterone
- Also called
- (3alpha,5alpha)-3-hydroxyandrostan-17-one(3α,5α)-3-hydroxyandrostan-17-one3-epihydroxyetioallocholan-17-one3alpha-hydroxyetioallocholan-17-one3α-hydroxyetioallocholan-17-one5alpha-androstane-3alpha-ol-17-one5alpha-androsterone5α-androstane-3α-ol-17-one5α-androsteroneAndrokinineAndrotinecis-androsteroneST 19:1;O2
- Systematic name
- 3alpha-hydroxy-5alpha-androstan-17-one3α-hydroxy-5α-androstan-17-one