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Proteins/UNIPROT:P00505
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). As a member of the malate-aspartate shuttle, it has a key role in the intracellular NAD(H) redox balance. Is important for metabolite exchange between mitochondria and cytosol, and for amino acid metabolism. Facilitates cellular uptake of long-chain free fatty acids..
Function from UniProtKB (P00505), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 1 · substrate of
1 compound
1 compound.
0 reported routes1 assembled route
2 rows
195 statements
195 statements · 8 reference databases · Subject: GOT2 · Sources: Bgee, Hetionet, Human Protein Atlas, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
14 reactions
2-oxoglutarate(2-)+L-phenylalanineL-glutamate(1-)+3-phenylpyruvate
Reaction pageReversibleBalancedEC 2.6.1.58mitochondrial matrix
Human-GEM MAR01616CC BY 4.0Reference data
2-oxoglutarate(2-)+L-aspartateL-glutamate(1-)+oxaloacetate
Catalysed by GOT2
Reaction pageReversibleBalanced
12 names
Resolves to: GOT2
Human-GEM MAR03827CC BY 4.0Reference data
3-sulfino-L-alanine+2-oxoglutarate(2-)+proton3-sulfinopyruvate+L-glutamate(1-)
Catalysed by GOT2
Reaction pageLeft to rightBalancedEC 2.6.1.1, 2.6.1.7mitochondrial matrix
Human-GEM MAR03865CC BY 4.0Reference data
2-oxoglutarate(2-)+L-cysteineL-glutamate(1-)+2-oxo-3-sulfanylpropanoate
Reaction pageReversibleBalancedEC 2.6.1.1, 2.6.1.3cytosol
Human-GEM MAR03912CC BY 4.0Reference data
2-oxoglutarate(2-)+MAM02358m4-hydroxy-2-oxoglutaric acid+L-glutamate(1-)
Reaction pageLeft to rightBalancedEC 2.6.1.1, 2.6.1.23mitochondrial matrix
Human-GEM MAR04786CC BY 4.0Reference data
2-oxoglutarate(2-)+L-phenylalanineL-glutamate(1-)+3-phenylpyruvate
Catalysed by GOT1 or GOT2 or TAT
Reaction pageReversibleBalancedEC 2.6.1.1, 2.6.1.5, 2.6.1.57cytosol
Human-GEM MAR06725CC BY 4.0Reference data
2-oxoglutarate(2-)+CHEBI:178953-(4-hydroxyphenyl)pyruvate+L-glutamate(1-)
Catalysed by GOT1 or GOT2 or TAT
Reaction pageLeft to rightBalancedEC 2.6.1.1, 2.6.1.5, 2.6.1.57cytosol
Human-GEM MAR06768CC BY 4.0Reference data
2-oxoglutarate(2-)+CHEBI:178953-(4-hydroxyphenyl)pyruvate+L-glutamate(1-)
Reaction pageLeft to rightBalancedEC 2.6.1.5, 2.6.1.57, 2.6.1.1mitochondrial matrix
Human-GEM MAR06780CC BY 4.0Reference data
MAM00920c+L-glutamate(1-)2-oxoglutarate(2-)+MAM02350c
Reaction pageReversibleBalancedEC 2.6.1.1, 2.6.1.3cytosol
Human-GEM MAR08066CC BY 4.0Reference data
MAM00920m+L-glutamate(1-)2-oxoglutarate(2-)+MAM02350m
Catalysed by GOT2
Reaction pageReversibleBalancedEC 2.6.1.1, 2.6.1.3mitochondrial matrix
Human-GEM MAR08067CC BY 4.0Reference data
MAM02358m+oxaloacetate4-hydroxy-2-oxoglutaric acid+L-aspartate
Catalysed by GOT2
Reaction pageLeft to rightBalancedEC 2.6.1.21mitochondrial matrix
Human-GEM MAR08098CC BY 4.0Reference data
2-oxoglutarate(2-)+L-cysteineL-glutamate(1-)+2-oxo-3-sulfanylpropanoate
Catalysed by GOT2
Reaction pageReversibleBalancedEC 2.6.1.1mitochondrial matrix
Human-GEM MAR08684CC BY 4.0Reference data