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Proteins/UNIPROT:P19801
Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia. Its preferred substrates are the diamines histamine and 1-methylhistamine and it could therefore play a role in allergic and immune responses. Has a broad specificity for diamines and can also act on cadaverine and putrescine, two products of amino acid catabolism. It could also act on polyamines, like spermidine and spermine though less efficiently, and regulate various biological processes..
Function from UniProtKB (P19801), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
59 statements
59 statements · 7 reference databases · Subject: AOC1 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, UniProt, WikiPathways
34 reactions
water+dioxygen+putrescineCHEBI:17769+proton+hydrogen peroxide+ammonium
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.10, 1.4.3.21, 1.4.3.22extracellular space
Human-GEM MAR04423CC BY 4.0Reference data
11 names
Resolves to: AOC1
Reaction pageLeft to rightBalancedEC 1.4.3.4cytosol
Human-GEM MAR04430CC BY 4.0Reference data
water+dioxygen+2-phenylethylamineproton+hydrogen peroxide+ammonium+2-phenylacetaldehyde
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.21cytosol
Human-GEM MAR04682CC BY 4.0Reference data
water+dioxygen+tryptamineproton+hydrogen peroxide+indole-3-acetaldehyde+ammonium
Catalysed by AOC1 or MAOB or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.22cytosol
Human-GEM MAR06713CC BY 4.0Reference data
dopamine+water+dioxygen3,4-dihydroxyphenylacetaldehyde+proton+hydrogen peroxide+ammonium
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.21, 1.4.3.22cytosol
Human-GEM MAR06758CC BY 4.0Reference data
water+dioxygen+MAM03099cMAM01002c+proton+hydrogen peroxide+ammonium
Catalysed by AOC1 or MAOB or AOC3 or AOC2 or MAOA
Reaction pageLeft to rightBalancedEC 1.4.3.4, 1.4.3.21cytosol
Human-GEM MAR06789CC BY 4.0Reference data
water+dioxygen+CHEBI:15746proton+hydrogen peroxide+ammonium+spermine monoaldehyde
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22cytosol
Human-GEM MAR06931CC BY 4.0Reference data
water+dioxygen+CHEBI:15746proton+hydrogen peroxide+ammonium+spermine monoaldehyde
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22extracellular space
Human-GEM MAR06932CC BY 4.0Reference data
FAD+water+CHEBI:15746FADH2+proton+ammonium+spermine monoaldehyde
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22peroxisome
Human-GEM MAR06933CC BY 4.0Reference data
water+dioxygen+spermine monoaldehydeproton+hydrogen peroxide+ammonium+MAM02924c
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22cytosol
Human-GEM MAR06934CC BY 4.0Reference data
water+dioxygen+spermine monoaldehydeproton+hydrogen peroxide+ammonium+MAM02924e
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22extracellular space
Human-GEM MAR06935CC BY 4.0Reference data
FAD+water+spermine monoaldehydeFADH2+proton+ammonium+MAM02924x
Catalysed by AOC1 or AOC3 or AOC2
Reaction pageLeft to rightBalancedEC 1.4.3.21, 1.4.3.22peroxisome
Human-GEM MAR06936CC BY 4.0Reference data