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Proteins/UNIPROT:O60669
Proton-coupled monocarboxylate symporter. Catalyzes the rapid transport across the plasma membrane of monocarboxylates such as L-lactate, pyruvate and ketone bodies, acetoacetate, beta-hydroxybutyrate and acetate. Dimerization is functionally required and both subunits work cooperatively in transporting substrate..
Function from UniProtKB (O60669), read 2026-09-23. CC BY 4.0.
Curated compounds routed: 0
140 statements
140 statements · 6 reference databases · Subject: SLC16A7 · Sources: Bgee, Hetionet, Human-GEM, Reactome, Rhea, WikiPathways
62 reactions
(R)-lactic acid+proton(R)-lactic acid+proton
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR03858CC BY 4.0Reference data
3 names
Resolves to: SLC16A7
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04928CC BY 4.0Reference data
proton+pyruvateproton+pyruvate
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, peroxisome
Human-GEM MAR04930CC BY 4.0Reference data
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04935CC BY 4.0Reference data
acetoacetate+protonacetoacetate+proton
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR04976CC BY 4.0Reference data
(R)-3-hydroxybutyric acid+proton(R)-3-hydroxybutyric acid+proton
Transported by SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedextracellular space, cytosol
Human-GEM MAR05018CC BY 4.0Reference data
2-oxobutanoate+proton2-oxobutanoate+proton
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedcytosol, mitochondrial matrix
Human-GEM MAR05348CC BY 4.0Reference data
2-oxobutanoate+proton2-oxobutanoate+proton
Transported by SLC16A8 or SLC16A6 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageLeft to rightBalancedmitochondrial matrix, mitochondrial intermembrane space, cytosol
Human-GEM MAR05349CC BY 4.0Reference data
proton+(S)-lactic acidproton+(S)-lactic acid
Transported by SLC16A8 or SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedextracellular space, cytosol
Human-GEM MAR05998CC BY 4.0Reference data
acetoacetate+pyruvateacetoacetate+pyruvate
Transported by SLC16A7 or SLC16A3 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06000CC BY 4.0Reference data
acetate+acetoacetateacetate+acetoacetate
Transported by SLC16A6 or SLC16A7 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06001CC BY 4.0Reference data
acetoacetate+propionic acidacetoacetate+propionic acid
Transported by SLC16A8 or SLC16A7 or SLC16A1 or SLC16A4 or SLC16A5
Reaction pageReversibleBalancedcytosol, extracellular space
Human-GEM MAR06003CC BY 4.0Reference data